TY - JOUR
T1 - International guidelines for the in vivo assessment of skin properties in non-clinical settings
T2 - Part 2. transepidermal water loss and skin hydration
AU - Plessis, Johan du
AU - Stefaniak, Aleksandr
AU - Eloff, Fritz
AU - John, Swen
AU - Agner, Tove
AU - Chou, Tzu-Chieh
AU - Nixon, Rosemary
AU - Steiner, Markus
AU - Franken, Anja
AU - Kudla, Irena
AU - Holness, Linn
N1 - Copyright 2013 Elsevier B.V., All rights reserved.
PY - 2013/8
Y1 - 2013/8
N2 - Background: There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin barrier function of the exposed skin at the time of exposure. The workplace environment, representing a non-clinical environment, can be highly variable and difficult to control, thereby presenting unique measurement challenges not typically encountered in clinical settings. Methods: An expert working group convened a workshop as part of the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals (OEESC) to develop basic guidelines and best practices (based on existing clinical guidelines, published data, and own experiences) for the in vivo measurement of transepidermal water loss (TEWL) and skin hydration in non-clinical settings with specific reference to the workplace as a worst-case scenario. Results: Key elements of these guidelines are: (i) to minimize or recognize, to the extent feasible, the influences of relevant endogenous-, exogenous-, environmental- and measurement/instrumentation-related factors; (ii) to measure TEWL with a closed-chamber type instrument; (iii) report results as a difference or percent change (rather than absolute values); and (iv) accurately report any notable deviations from this guidelines. Conclusion: It is anticipated that these guidelines will promote consistent data reporting, which will facilitate inter-comparison of study results.
AB - Background: There is an emerging perspective that it is not sufficient to just assess skin exposure to physical and chemical stressors in workplaces, but that it is also important to assess the condition, i.e. skin barrier function of the exposed skin at the time of exposure. The workplace environment, representing a non-clinical environment, can be highly variable and difficult to control, thereby presenting unique measurement challenges not typically encountered in clinical settings. Methods: An expert working group convened a workshop as part of the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals (OEESC) to develop basic guidelines and best practices (based on existing clinical guidelines, published data, and own experiences) for the in vivo measurement of transepidermal water loss (TEWL) and skin hydration in non-clinical settings with specific reference to the workplace as a worst-case scenario. Results: Key elements of these guidelines are: (i) to minimize or recognize, to the extent feasible, the influences of relevant endogenous-, exogenous-, environmental- and measurement/instrumentation-related factors; (ii) to measure TEWL with a closed-chamber type instrument; (iii) report results as a difference or percent change (rather than absolute values); and (iv) accurately report any notable deviations from this guidelines. Conclusion: It is anticipated that these guidelines will promote consistent data reporting, which will facilitate inter-comparison of study results.
KW - skin hydration
KW - transepidermal water loss
KW - skin barrier
KW - stratum corneum
KW - guideline
KW - non-clinical
UR - http://www.scopus.com/inward/record.url?scp=84872285934&partnerID=8YFLogxK
U2 - 10.1111/srt.12037
DO - 10.1111/srt.12037
M3 - Article
C2 - 23331328
AN - SCOPUS:84880350908
SN - 0909-752X
VL - 19
SP - 265
EP - 278
JO - Skin Research & Technology
JF - Skin Research & Technology
IS - 3
ER -