Intestinal colonization resistance

Trevor D Lawley, Alan W Walker

Research output: Contribution to journalLiterature review

191 Citations (Scopus)

Abstract

Dense, complex microbial communities, collectively termed the microbiota, occupy a diverse array of niches along the length of the mammalian intestinal tract. During health and in the absence of antibiotic exposure the microbiota can effectively inhibit colonization and overgrowth by invading microbes such as pathogens. This phenomenon is called 'colonization resistance' and is associated with a stable and diverse microbiota in tandem with a controlled lack of inflammation, and involves specific interactions between the mucosal immune system and the microbiota. Here we overview the microbial ecology of the healthy mammalian intestinal tract and highlight the microbe-microbe and microbe-host interactions that promote colonization resistance. Emerging themes highlight immunological (T helper type 17/regulatory T-cell balance), microbiota (diverse and abundant) and metabolic (short-chain fatty acid) signatures of intestinal health and colonization resistance. Intestinal pathogens use specific virulence factors or exploit antibiotic use to subvert colonization resistance for their own benefit by triggering inflammation to disrupt the harmony of the intestinal ecosystem. A holistic view that incorporates immunological and microbiological facets of the intestinal ecosystem should facilitate the development of immunomodulatory and microbe-modulatory therapies that promote intestinal homeostasis and colonization resistance.
Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalImmunology
Volume138
Issue number1
Early online date13 Dec 2012
DOIs
Publication statusPublished - Jan 2013

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Microbiota
Ecosystem
Anti-Bacterial Agents
Inflammation
Volatile Fatty Acids
Health
Virulence Factors
Regulatory T-Lymphocytes
Ecology
Immune System
Homeostasis

Keywords

  • animals
  • gastrointestinal tract
  • humans
  • microbial interactions
  • bacteriotherapy
  • colonization resistance
  • inflammation
  • intestinal microbiota
  • pathogens
  • short-chain fatty acids
  • T helper type 17/regulatory T-cell balance

Cite this

Intestinal colonization resistance. / Lawley, Trevor D; Walker, Alan W.

In: Immunology, Vol. 138, No. 1, 01.2013, p. 1-11.

Research output: Contribution to journalLiterature review

Lawley, Trevor D ; Walker, Alan W. / Intestinal colonization resistance. In: Immunology. 2013 ; Vol. 138, No. 1. pp. 1-11.
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