Intracranial compliance is associated with symptoms of orthostatic intolerance in chronic fatigue syndrome

Andreas Finkelmeyer, Jiabao He, Laura Maclachlan, Andrew M. Blamire, Julia Newton

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Abstract

Symptoms of orthostatic intolerance (OI) are common in Chronic Fatigue Syndrome (CFS) and similar disorders. These symptoms may relate to individual differences in intracranial compliance and cerebral blood perfusion. The present study used phase-contrast, quantitative flow magnetic resonance imaging (MRI) to determine intracranial compliance based on arterial inflow, venous outflow and cerebrospinal fluid flow along the spinal canal into and out of the cranial cavity. Flow-sensitive Alternating Inversion Recovery (FAIR) Arterial Spin Labelling was used to measure cerebral blood perfusion at rest. Forty patients with CFS and 10 age and gender matched controls were scanned. Severity of symptoms of OI was determined from self-report using the Autonomic Symptom Profile. CFS patients reported significantly higher levels of OI (p < .001). Within the patient group, higher severity of OI symptoms were associated with lower intracranial compliance (r = -.346, p = .033) and higher resting perfusion (r = .337, p = .038). In both groups intracranial compliance was negatively correlated with cerebral perfusion. There were no significant differences between the groups in intracranial compliance or perfusion. In patients with CFS, low intracranial compliance and high resting cerebral perfusion appear to be associated with an increased severity of symptoms of OI. This may signify alterations in the ability of the cerebral vasculature to cope with changes to systemic blood pressure due to orthostatic stress, but this may not be specific to CFS.
Original languageEnglish
Article number0200068
JournalPloS ONE
Volume13
Issue number7
Early online date3 Jul 2018
DOIs
Publication statusPublished - 2018

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Orthostatic Intolerance
Chronic Fatigue Syndrome
compliance
signs and symptoms (animals and humans)
Compliance
Perfusion
Fatigue of materials
Blood
Cerebrospinal fluid
blood
Blood pressure
cerebrospinal fluid
Canals
Magnetic resonance
Spinal Canal
Aptitude
magnetic resonance imaging
blood pressure
Flow of fluids
Individuality

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Intracranial compliance is associated with symptoms of orthostatic intolerance in chronic fatigue syndrome. / Finkelmeyer, Andreas; He, Jiabao; Maclachlan, Laura; Blamire, Andrew M.; Newton, Julia.

In: PloS ONE, Vol. 13, No. 7, 0200068, 2018.

Research output: Contribution to journalArticle

Finkelmeyer, Andreas ; He, Jiabao ; Maclachlan, Laura ; Blamire, Andrew M. ; Newton, Julia. / Intracranial compliance is associated with symptoms of orthostatic intolerance in chronic fatigue syndrome. In: PloS ONE. 2018 ; Vol. 13, No. 7.
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