Investigating retinal therapies using ex vivo retinal explants

Virpi Alarautalahti*, Symantas Ragauskas, Andrea Holme, Hannele Uusitalo-Järvinen, Hannu Uusitalo, Jari Hyttinen, Giedrius Kalesnykas, Soile Nymark

*Corresponding author for this work

Research output: Contribution to conferenceAbstract

Abstract

Retinal degenerative diseases cause an enormous economic burden to the society and decrease the life quality and independence of affected patients. Currently, there are no therapies that would cure these diseases and restore vision. Thus, new treatments are urgently needed. In vitro retina model systems would facilitate the therapy development, and enable the investigation of the effects, benefits and risks of the medical treatments to the retinal tissue. In this study, we tested an organotypic retinal explant culture system and its potential as a tool for the investigations of retinal therapies, focusing on the effects of drugs to the functioning and morphology of the retina.
Original languageEnglish
DOIs
Publication statusPublished - 24 Jun 2016
EventMEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays - Reutlingen, Germany
Duration: 28 Jun 20161 Jul 2016

Conference

ConferenceMEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays
CountryGermany
CityReutlingen
Period28/06/161/07/16

Keywords

  • Retina
  • Culture system
  • Retinal explants
  • perforated MEA

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    Alarautalahti, V., Ragauskas, S., Holme, A., Uusitalo-Järvinen, H., Uusitalo, H., Hyttinen, J., Kalesnykas, G., & Nymark, S. (2016). Investigating retinal therapies using ex vivo retinal explants. Abstract from MEA Meeting 2016, 10th International Meeting on Substrate-Integrated Electrode Arrays, Reutlingen, Germany. https://doi.org/10.3389/conf.fnins.2016.93.00036