KLOTHO genotype and cognitive ability in childhood and old age in the same individuals

I. J. Deary, S. E. Harris, Helen Catherine Fox, C. Hayward, A. F. Wright, J. M. Starr, Lawrence Jeffrey Whalley

    Research output: Contribution to journalArticle

    62 Citations (Scopus)

    Abstract

    This study examined the influence of a variation in the KLOTHO gene on cognitive ability at age 11 and age 79 in 464 people from the Lothian Birth Cohort 1921 (LBC 1921), and at age 11 and age 64 in 451 people in the Aberdeen Birth Cohort 1936 (ABCI 936). In the LBC 1921, people with the KLOTHO V/V genotype had lower verbal reasoning ability at age 11 and age 79, and lower non-verbal reasoning at age 79, than those with the F/F genotype, or heterozygotes. The effect of the KLOTHO polymorphism on cognition at age 79 was non-significant when adjusted for IQ at age 11. In this sample, KLOTHO V allele status accounts for about 2% of the variance in life-long traits related to verbal and non-verbal reasoning, but not to age-related cognitive change. These results were not replicated in the ABC 1936 sample. In a combined analysis of the LBC 1921 and the ABC 1936 cohorts there was a significant KLOTHO x sex interaction: women with the VN genotype had lower non-verbal reasoning scores at age 79, after adjustment for cognitive ability at age 11. Variation in the KLOTHO gene is a possible contributor to life-long reasoning differences in humans and/or to the ageing of non-verbal reasoning, especially in women. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

    Original languageEnglish
    Pages (from-to)22-27
    Number of pages5
    JournalNeuroscience
    Volume378
    DOIs
    Publication statusPublished - 2005

    Keywords

    • cognition
    • intelligence
    • ageing
    • genes
    • klotho
    • SCOTTISH MENTAL SURVEY
    • LATER LIFE
    • FOLLOW-UP
    • GENE
    • INTELLIGENCE
    • MEMBRANE
    • PROTEIN
    • ALLELE
    • RISK

    Cite this

    Deary, I. J., Harris, S. E., Fox, H. C., Hayward, C., Wright, A. F., Starr, J. M., & Whalley, L. J. (2005). KLOTHO genotype and cognitive ability in childhood and old age in the same individuals. Neuroscience, 378, 22-27. https://doi.org/10.1016/j.neulet.2004.12.005

    KLOTHO genotype and cognitive ability in childhood and old age in the same individuals. / Deary, I. J.; Harris, S. E.; Fox, Helen Catherine; Hayward, C.; Wright, A. F.; Starr, J. M.; Whalley, Lawrence Jeffrey.

    In: Neuroscience, Vol. 378, 2005, p. 22-27.

    Research output: Contribution to journalArticle

    Deary, IJ, Harris, SE, Fox, HC, Hayward, C, Wright, AF, Starr, JM & Whalley, LJ 2005, 'KLOTHO genotype and cognitive ability in childhood and old age in the same individuals', Neuroscience, vol. 378, pp. 22-27. https://doi.org/10.1016/j.neulet.2004.12.005
    Deary, I. J. ; Harris, S. E. ; Fox, Helen Catherine ; Hayward, C. ; Wright, A. F. ; Starr, J. M. ; Whalley, Lawrence Jeffrey. / KLOTHO genotype and cognitive ability in childhood and old age in the same individuals. In: Neuroscience. 2005 ; Vol. 378. pp. 22-27.
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    abstract = "This study examined the influence of a variation in the KLOTHO gene on cognitive ability at age 11 and age 79 in 464 people from the Lothian Birth Cohort 1921 (LBC 1921), and at age 11 and age 64 in 451 people in the Aberdeen Birth Cohort 1936 (ABCI 936). In the LBC 1921, people with the KLOTHO V/V genotype had lower verbal reasoning ability at age 11 and age 79, and lower non-verbal reasoning at age 79, than those with the F/F genotype, or heterozygotes. The effect of the KLOTHO polymorphism on cognition at age 79 was non-significant when adjusted for IQ at age 11. In this sample, KLOTHO V allele status accounts for about 2{\%} of the variance in life-long traits related to verbal and non-verbal reasoning, but not to age-related cognitive change. These results were not replicated in the ABC 1936 sample. In a combined analysis of the LBC 1921 and the ABC 1936 cohorts there was a significant KLOTHO x sex interaction: women with the VN genotype had lower non-verbal reasoning scores at age 79, after adjustment for cognitive ability at age 11. Variation in the KLOTHO gene is a possible contributor to life-long reasoning differences in humans and/or to the ageing of non-verbal reasoning, especially in women. (c) 2004 Elsevier Ireland Ltd. All rights reserved.",
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    AB - This study examined the influence of a variation in the KLOTHO gene on cognitive ability at age 11 and age 79 in 464 people from the Lothian Birth Cohort 1921 (LBC 1921), and at age 11 and age 64 in 451 people in the Aberdeen Birth Cohort 1936 (ABCI 936). In the LBC 1921, people with the KLOTHO V/V genotype had lower verbal reasoning ability at age 11 and age 79, and lower non-verbal reasoning at age 79, than those with the F/F genotype, or heterozygotes. The effect of the KLOTHO polymorphism on cognition at age 79 was non-significant when adjusted for IQ at age 11. In this sample, KLOTHO V allele status accounts for about 2% of the variance in life-long traits related to verbal and non-verbal reasoning, but not to age-related cognitive change. These results were not replicated in the ABC 1936 sample. In a combined analysis of the LBC 1921 and the ABC 1936 cohorts there was a significant KLOTHO x sex interaction: women with the VN genotype had lower non-verbal reasoning scores at age 79, after adjustment for cognitive ability at age 11. Variation in the KLOTHO gene is a possible contributor to life-long reasoning differences in humans and/or to the ageing of non-verbal reasoning, especially in women. (c) 2004 Elsevier Ireland Ltd. All rights reserved.

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