Left dorso-lateral repetitive transcranial magnetic stimulation affects cortical excitability and functional connectivity, but does not impair cognition in major depression

P. M. Shajahan, M. F. Glabus, John Douglas Steele, A. B. Doris, K. Anderson, J. A. Jenkins, P. A. Gooding, K. P. Ebmeier

    Research output: Contribution to journalArticle

    87 Citations (Scopus)

    Abstract

    Purpose: Transcranial magnetic stimulation (TMS) has been used for over a decade to investigate cortical function. More recently, it has been employed to treat conditions such as major depression. This study was designed to explore the effects of differential treatment parameters, such as stimulation frequency. In addition, the data were examined to determine whether a change in connectivity occurred following TMS. Method: Fifteen patients with major depression were entered into a combined imaging and treatment experiment with single photon emission computed tomography (SPELT) and repetitive transcranial magnetic stimulation (rTMS) over left dorso-lateral prefrontal cortex (DLPFC). Brain perfusion during a verbal fluency task was compared between pre- and poststimulation conditions. Patients were then treated with 80% of motor threshold for a total of 10 days, using 5000 stimuli at 5, 10 or 20 Hz. Tests of cortical excitability and neuropsychological tests were done throughout the trial. Findings: Patients generally improved with treatment. There was no perceptible difference between stimulation frequencies, which may have reflected low study power. An increase in rostral anterior cingulate activation after the first treatment day was associated with increased functional connectivity in the dorso-lateral frontal loop on the left and the limbic loop on both sides. No noticeable deterioration in neuropsychological function was observed. Conclusion: TMS at the stimulation frequencies used seems to be safe over a course of 5000 stimuli. It appears to have an activating effect in anterior limbic structures and increase functional connectivity in the neuroanatomical networks under the stimulation coil within an hour of stimulation. (C) 2002 Elsevier Science Inc. All rights reserved.

    Original languageEnglish
    Pages (from-to)945-954
    Number of pages9
    JournalProgress in Neuro -Psychopharmacology & Biological Psychiatry
    Volume26
    Publication statusPublished - 2002

    Keywords

    • cortical excitability
    • major depressive episode
    • neuropsychology
    • regional cerebral blood flow
    • single photon emission tomography
    • transcranial magnetic stimulation
    • NEUROPSYCHOLOGICAL FUNCTION
    • DIURNAL-VARIATION
    • CORTEX
    • MOOD
    • RTMS

    Cite this

    Left dorso-lateral repetitive transcranial magnetic stimulation affects cortical excitability and functional connectivity, but does not impair cognition in major depression. / Shajahan, P. M.; Glabus, M. F.; Steele, John Douglas; Doris, A. B.; Anderson, K.; Jenkins, J. A.; Gooding, P. A.; Ebmeier, K. P.

    In: Progress in Neuro -Psychopharmacology & Biological Psychiatry, Vol. 26, 2002, p. 945-954.

    Research output: Contribution to journalArticle

    Shajahan, P. M. ; Glabus, M. F. ; Steele, John Douglas ; Doris, A. B. ; Anderson, K. ; Jenkins, J. A. ; Gooding, P. A. ; Ebmeier, K. P. / Left dorso-lateral repetitive transcranial magnetic stimulation affects cortical excitability and functional connectivity, but does not impair cognition in major depression. In: Progress in Neuro -Psychopharmacology & Biological Psychiatry. 2002 ; Vol. 26. pp. 945-954.
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    abstract = "Purpose: Transcranial magnetic stimulation (TMS) has been used for over a decade to investigate cortical function. More recently, it has been employed to treat conditions such as major depression. This study was designed to explore the effects of differential treatment parameters, such as stimulation frequency. In addition, the data were examined to determine whether a change in connectivity occurred following TMS. Method: Fifteen patients with major depression were entered into a combined imaging and treatment experiment with single photon emission computed tomography (SPELT) and repetitive transcranial magnetic stimulation (rTMS) over left dorso-lateral prefrontal cortex (DLPFC). Brain perfusion during a verbal fluency task was compared between pre- and poststimulation conditions. Patients were then treated with 80{\%} of motor threshold for a total of 10 days, using 5000 stimuli at 5, 10 or 20 Hz. Tests of cortical excitability and neuropsychological tests were done throughout the trial. Findings: Patients generally improved with treatment. There was no perceptible difference between stimulation frequencies, which may have reflected low study power. An increase in rostral anterior cingulate activation after the first treatment day was associated with increased functional connectivity in the dorso-lateral frontal loop on the left and the limbic loop on both sides. No noticeable deterioration in neuropsychological function was observed. Conclusion: TMS at the stimulation frequencies used seems to be safe over a course of 5000 stimuli. It appears to have an activating effect in anterior limbic structures and increase functional connectivity in the neuroanatomical networks under the stimulation coil within an hour of stimulation. (C) 2002 Elsevier Science Inc. All rights reserved.",
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    TY - JOUR

    T1 - Left dorso-lateral repetitive transcranial magnetic stimulation affects cortical excitability and functional connectivity, but does not impair cognition in major depression

    AU - Shajahan, P. M.

    AU - Glabus, M. F.

    AU - Steele, John Douglas

    AU - Doris, A. B.

    AU - Anderson, K.

    AU - Jenkins, J. A.

    AU - Gooding, P. A.

    AU - Ebmeier, K. P.

    PY - 2002

    Y1 - 2002

    N2 - Purpose: Transcranial magnetic stimulation (TMS) has been used for over a decade to investigate cortical function. More recently, it has been employed to treat conditions such as major depression. This study was designed to explore the effects of differential treatment parameters, such as stimulation frequency. In addition, the data were examined to determine whether a change in connectivity occurred following TMS. Method: Fifteen patients with major depression were entered into a combined imaging and treatment experiment with single photon emission computed tomography (SPELT) and repetitive transcranial magnetic stimulation (rTMS) over left dorso-lateral prefrontal cortex (DLPFC). Brain perfusion during a verbal fluency task was compared between pre- and poststimulation conditions. Patients were then treated with 80% of motor threshold for a total of 10 days, using 5000 stimuli at 5, 10 or 20 Hz. Tests of cortical excitability and neuropsychological tests were done throughout the trial. Findings: Patients generally improved with treatment. There was no perceptible difference between stimulation frequencies, which may have reflected low study power. An increase in rostral anterior cingulate activation after the first treatment day was associated with increased functional connectivity in the dorso-lateral frontal loop on the left and the limbic loop on both sides. No noticeable deterioration in neuropsychological function was observed. Conclusion: TMS at the stimulation frequencies used seems to be safe over a course of 5000 stimuli. It appears to have an activating effect in anterior limbic structures and increase functional connectivity in the neuroanatomical networks under the stimulation coil within an hour of stimulation. (C) 2002 Elsevier Science Inc. All rights reserved.

    AB - Purpose: Transcranial magnetic stimulation (TMS) has been used for over a decade to investigate cortical function. More recently, it has been employed to treat conditions such as major depression. This study was designed to explore the effects of differential treatment parameters, such as stimulation frequency. In addition, the data were examined to determine whether a change in connectivity occurred following TMS. Method: Fifteen patients with major depression were entered into a combined imaging and treatment experiment with single photon emission computed tomography (SPELT) and repetitive transcranial magnetic stimulation (rTMS) over left dorso-lateral prefrontal cortex (DLPFC). Brain perfusion during a verbal fluency task was compared between pre- and poststimulation conditions. Patients were then treated with 80% of motor threshold for a total of 10 days, using 5000 stimuli at 5, 10 or 20 Hz. Tests of cortical excitability and neuropsychological tests were done throughout the trial. Findings: Patients generally improved with treatment. There was no perceptible difference between stimulation frequencies, which may have reflected low study power. An increase in rostral anterior cingulate activation after the first treatment day was associated with increased functional connectivity in the dorso-lateral frontal loop on the left and the limbic loop on both sides. No noticeable deterioration in neuropsychological function was observed. Conclusion: TMS at the stimulation frequencies used seems to be safe over a course of 5000 stimuli. It appears to have an activating effect in anterior limbic structures and increase functional connectivity in the neuroanatomical networks under the stimulation coil within an hour of stimulation. (C) 2002 Elsevier Science Inc. All rights reserved.

    KW - cortical excitability

    KW - major depressive episode

    KW - neuropsychology

    KW - regional cerebral blood flow

    KW - single photon emission tomography

    KW - transcranial magnetic stimulation

    KW - NEUROPSYCHOLOGICAL FUNCTION

    KW - DIURNAL-VARIATION

    KW - CORTEX

    KW - MOOD

    KW - RTMS

    M3 - Article

    VL - 26

    SP - 945

    EP - 954

    JO - Progress in Neuro -Psychopharmacology & Biological Psychiatry

    JF - Progress in Neuro -Psychopharmacology & Biological Psychiatry

    SN - 0278-5846

    ER -