Left ventricular torsion and strain patterns in heart failure with normal ejection fraction are similar to age-related changes

Thanh Trung Phan, Ganesh Nallur Shivu, Khalid Abozguia, Mahadevan Gnanadevan, Ibrar Ahmed, Michael Frenneaux

Research output: Contribution to journalArticle

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Abstract

We used speckle tracking echocardiography (STE) to make a comparison between the effects of ageing and of heart failure with normal ejection fraction (HfnEF) on left ventricular (LV) torsion and strain patterns.

Forty patients with HfnEF, 27 young controls and 26 older controls, were prospectively recruited. All subjects underwent clinical examination, 12-lead electrocardiogram, pulmonary function test, echocardiogram, and metabolic exercise test. LV torsion increases with advancing age (older controls vs. young controls, 2.2 +/- 0.9 vs. 1.4 +/- 0.8 degrees/cm; P = 0.03). Circumferential strain was enhanced in patients with HfnEF (-24.7 +/- 4.7 vs. -20.0 +/- 4.9%; P = 0.003). Rotational deformation delay (time difference between peak basal rotation and peak apical rotation), global circumferential strain, E-velocity deceleration time, and LV end-diastolic volume index were independent predictors of LV torsion. LV torsion and body mass index were independent predictors of LV untwist rate.

Ageing is associated with increased LV torsion secondary to reduced rotational deformation delay and increased peak basal rotation. LV torsion and strain patterns in patients with HfnEF are similar to age-related changes apart from circumferential strain, which is enhanced in patients with HfnEF.

Original languageEnglish
Pages (from-to)793-800
Number of pages8
JournalEuropean Journal of Echocardiography
Volume10
Issue number6
Early online date6 Jun 2009
DOIs
Publication statusPublished - Aug 2009

Keywords

  • torsion
  • untwisting
  • heart failure with normal ejection fraction
  • ageing
  • speckle tracking echocardiography
  • diastolic dysfunction
  • aortic-stenosis
  • relaxation
  • deformation
  • mechanics
  • humans
  • twist
  • prevalence
  • volume

Cite this

Left ventricular torsion and strain patterns in heart failure with normal ejection fraction are similar to age-related changes. / Phan, Thanh Trung; Shivu, Ganesh Nallur; Abozguia, Khalid; Gnanadevan, Mahadevan; Ahmed, Ibrar; Frenneaux, Michael.

In: European Journal of Echocardiography, Vol. 10, No. 6, 08.2009, p. 793-800.

Research output: Contribution to journalArticle

Phan, Thanh Trung ; Shivu, Ganesh Nallur ; Abozguia, Khalid ; Gnanadevan, Mahadevan ; Ahmed, Ibrar ; Frenneaux, Michael. / Left ventricular torsion and strain patterns in heart failure with normal ejection fraction are similar to age-related changes. In: European Journal of Echocardiography. 2009 ; Vol. 10, No. 6. pp. 793-800.
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AB - We used speckle tracking echocardiography (STE) to make a comparison between the effects of ageing and of heart failure with normal ejection fraction (HfnEF) on left ventricular (LV) torsion and strain patterns.Forty patients with HfnEF, 27 young controls and 26 older controls, were prospectively recruited. All subjects underwent clinical examination, 12-lead electrocardiogram, pulmonary function test, echocardiogram, and metabolic exercise test. LV torsion increases with advancing age (older controls vs. young controls, 2.2 +/- 0.9 vs. 1.4 +/- 0.8 degrees/cm; P = 0.03). Circumferential strain was enhanced in patients with HfnEF (-24.7 +/- 4.7 vs. -20.0 +/- 4.9%; P = 0.003). Rotational deformation delay (time difference between peak basal rotation and peak apical rotation), global circumferential strain, E-velocity deceleration time, and LV end-diastolic volume index were independent predictors of LV torsion. LV torsion and body mass index were independent predictors of LV untwist rate.Ageing is associated with increased LV torsion secondary to reduced rotational deformation delay and increased peak basal rotation. LV torsion and strain patterns in patients with HfnEF are similar to age-related changes apart from circumferential strain, which is enhanced in patients with HfnEF.

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