Leptin - Signals and secretions from white adipose tissue

P Trayhurn, J H Beattie, D V Rayner

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    The classical view of white adipose tissue is of an organ concerned with the storage of lipid, responding passively to changes in energy balance. It is now evident that white fat is an important secretory and endocrine organ which plays a wide role in metabolic and physiological regulation. It secretes, in particular, a critical signal in the control of energy balance, i.e. leptin. This hormone is also, implicated in a range of other processes, from reproduction to immunity and angiogenesis. A wide variety of protein secretions from white fat have now been identified, including angiotensinogen, plasminogen activator inhibitor-1, retinol binding protein adiponectin and interleukin-6, and these are associated with processes as diverse as haemostasis and the control of blued pressure. It is clear that white adipose tissue has come 'in from the cold'.

    Original languageEnglish
    Title of host publicationLIFE IN THE COLD
    EditorsG Heldmaier, M Klingenspor
    Place of PublicationBERLIN
    PublisherSPRINGER-VERLAG BERLIN
    Pages459-469
    Number of pages11
    ISBN (Print)3-540-67410-1
    Publication statusPublished - 2000
    Event11th International Hibernation Symposium on Life in the Cold - JUNGHOLZ
    Duration: 13 Aug 200018 Aug 2000

    Conference

    Conference11th International Hibernation Symposium on Life in the Cold
    CityJUNGHOLZ
    Period13/08/0018/08/00

    Keywords

    • RECEPTOR MESSENGER-RNA
    • PLASMINOGEN-ACTIVATOR INHIBITOR-1
    • SYMPATHETIC NERVOUS-SYSTEM
    • IN-SITU HYBRIDIZATION
    • OBESE GENE-PRODUCT
    • INSULIN-RESISTANCE
    • DIABETES-MELLITUS
    • RAT ADIPOCYTES
    • FEMALE MICE
    • BODY-WEIGHT

    Cite this