Leptin - Signals and secretions from white adipose tissue

P Trayhurn, J H Beattie, D V Rayner

Research output: Chapter in Book/Report/Conference proceedingPublished conference contribution

Abstract

The classical view of white adipose tissue is of an organ concerned with the storage of lipid, responding passively to changes in energy balance. It is now evident that white fat is an important secretory and endocrine organ which plays a wide role in metabolic and physiological regulation. It secretes, in particular, a critical signal in the control of energy balance, i.e. leptin. This hormone is also, implicated in a range of other processes, from reproduction to immunity and angiogenesis. A wide variety of protein secretions from white fat have now been identified, including angiotensinogen, plasminogen activator inhibitor-1, retinol binding protein adiponectin and interleukin-6, and these are associated with processes as diverse as haemostasis and the control of blued pressure. It is clear that white adipose tissue has come 'in from the cold'.

Original languageEnglish
Title of host publicationLIFE IN THE COLD
EditorsG Heldmaier, M Klingenspor
Place of PublicationBERLIN
PublisherSPRINGER-VERLAG BERLIN
Pages459-469
Number of pages11
ISBN (Print)3-540-67410-1
Publication statusPublished - 2000
Event11th International Hibernation Symposium on Life in the Cold - JUNGHOLZ
Duration: 13 Aug 200018 Aug 2000

Conference

Conference11th International Hibernation Symposium on Life in the Cold
CityJUNGHOLZ
Period13/08/0018/08/00

Keywords

  • RECEPTOR MESSENGER-RNA
  • PLASMINOGEN-ACTIVATOR INHIBITOR-1
  • SYMPATHETIC NERVOUS-SYSTEM
  • IN-SITU HYBRIDIZATION
  • OBESE GENE-PRODUCT
  • INSULIN-RESISTANCE
  • DIABETES-MELLITUS
  • RAT ADIPOCYTES
  • FEMALE MICE
  • BODY-WEIGHT

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