Long-term effectiveness of weight-loss interventions in adults with pre-diabetes: a review

S. L. Norris, X. Zhang, Alison Avenell, E. Gregg, B. Bowman, Christoph Schmidt, J. Lau

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Objective: To assess the effectiveness of weight-loss and weight-control interventions for adults with pre-diabetes (impaired fasting glucose and impaired glucose tolerance), an important risk factor for the development of type 2 diabetes.
Methods: Computerized searches were conducted of multiple electronic bibliographic databases tip to August 2003. Randomized controlled trials in any language were selected that examined weight-loss or weight-control strategies rising at least one dietary, physical activity, or behavioral intervention, and with a follow-up interval of aparts per thousandY12 months. Effects were combined using a random effects model.
Results: Studies were identified, with a total of 5168 participants. Follow-up ranged front 1 to 10 years. Quantitative synthesis was limited by the heterogeneity of populations, settings, and interventions, and by the small number of studies that examined outcomes other than weight. Overall, compared to usual care, font Studies with a follow-up of 1 year reduced weight by 2.8 kg (95% confidence interval [CI] 1.0-4.7) (3.3% of baseline body weight) and decreased body mass index by 1.4 kg/m(2) (CI=0.5-2.3). Weight loss at 2 bears was 2.7 kg (CI=1.9-3.4) (two studies). Modest improvements were noted in the few studies that examined glycemic control, blood pressure, and lipid concentrations (p>0.05). The incidence of diabetes was significantly lower in the intervention groups versus the controls in three of five studies examining this outcome at 3 to 6 years follow-up.
Conclusions: Overall, weight-loss strategies rising dietary, physical activity, or behavioral interventions produced significant improvements in weight among persons with pre-diabetes, and a significant decrease in diabetes incidence. Further work is needed on the long-term effects of these interventions on morbidity and mortality and on how to implement these interventions in the community setting. (C) 2005 American Journal of Preventive Medicine.

Original languageEnglish
Pages (from-to)126-139
Number of pages13
JournalAmerican Journal of Preventive Medicine
Volume28
Issue number1
DOIs
Publication statusPublished - 2005

Keywords

  • Impaired glucose-tolerance
  • type 2 diabetes mellitus
  • lifestyle intervention
  • body fat distribution
  • Da Qing IGT
  • preventio program
  • randomized trial
  • glycemic control
  • behavioral treatment
  • insulin resistance

Cite this

Long-term effectiveness of weight-loss interventions in adults with pre-diabetes : a review. / Norris, S. L.; Zhang, X.; Avenell, Alison; Gregg, E.; Bowman, B.; Schmidt, Christoph; Lau, J.

In: American Journal of Preventive Medicine, Vol. 28, No. 1, 2005, p. 126-139.

Research output: Contribution to journalArticle

Norris, S. L. ; Zhang, X. ; Avenell, Alison ; Gregg, E. ; Bowman, B. ; Schmidt, Christoph ; Lau, J. / Long-term effectiveness of weight-loss interventions in adults with pre-diabetes : a review. In: American Journal of Preventive Medicine. 2005 ; Vol. 28, No. 1. pp. 126-139.
@article{43f329fa310e459fae67d705da333ee1,
title = "Long-term effectiveness of weight-loss interventions in adults with pre-diabetes: a review",
abstract = "Objective: To assess the effectiveness of weight-loss and weight-control interventions for adults with pre-diabetes (impaired fasting glucose and impaired glucose tolerance), an important risk factor for the development of type 2 diabetes. Methods: Computerized searches were conducted of multiple electronic bibliographic databases tip to August 2003. Randomized controlled trials in any language were selected that examined weight-loss or weight-control strategies rising at least one dietary, physical activity, or behavioral intervention, and with a follow-up interval of aparts per thousandY12 months. Effects were combined using a random effects model. Results: Studies were identified, with a total of 5168 participants. Follow-up ranged front 1 to 10 years. Quantitative synthesis was limited by the heterogeneity of populations, settings, and interventions, and by the small number of studies that examined outcomes other than weight. Overall, compared to usual care, font Studies with a follow-up of 1 year reduced weight by 2.8 kg (95{\%} confidence interval [CI] 1.0-4.7) (3.3{\%} of baseline body weight) and decreased body mass index by 1.4 kg/m(2) (CI=0.5-2.3). Weight loss at 2 bears was 2.7 kg (CI=1.9-3.4) (two studies). Modest improvements were noted in the few studies that examined glycemic control, blood pressure, and lipid concentrations (p>0.05). The incidence of diabetes was significantly lower in the intervention groups versus the controls in three of five studies examining this outcome at 3 to 6 years follow-up. Conclusions: Overall, weight-loss strategies rising dietary, physical activity, or behavioral interventions produced significant improvements in weight among persons with pre-diabetes, and a significant decrease in diabetes incidence. Further work is needed on the long-term effects of these interventions on morbidity and mortality and on how to implement these interventions in the community setting. (C) 2005 American Journal of Preventive Medicine.",
keywords = "Impaired glucose-tolerance, type 2 diabetes mellitus, lifestyle intervention, body fat distribution, Da Qing IGT, preventio program, randomized trial, glycemic control, behavioral treatment, insulin resistance",
author = "Norris, {S. L.} and X. Zhang and Alison Avenell and E. Gregg and B. Bowman and Christoph Schmidt and J. Lau",
year = "2005",
doi = "10.1016/j.amepre.2004.08.006",
language = "English",
volume = "28",
pages = "126--139",
journal = "American Journal of Preventive Medicine",
issn = "0749-3797",
publisher = "Elsevier Inc.",
number = "1",

}

TY - JOUR

T1 - Long-term effectiveness of weight-loss interventions in adults with pre-diabetes

T2 - a review

AU - Norris, S. L.

AU - Zhang, X.

AU - Avenell, Alison

AU - Gregg, E.

AU - Bowman, B.

AU - Schmidt, Christoph

AU - Lau, J.

PY - 2005

Y1 - 2005

N2 - Objective: To assess the effectiveness of weight-loss and weight-control interventions for adults with pre-diabetes (impaired fasting glucose and impaired glucose tolerance), an important risk factor for the development of type 2 diabetes. Methods: Computerized searches were conducted of multiple electronic bibliographic databases tip to August 2003. Randomized controlled trials in any language were selected that examined weight-loss or weight-control strategies rising at least one dietary, physical activity, or behavioral intervention, and with a follow-up interval of aparts per thousandY12 months. Effects were combined using a random effects model. Results: Studies were identified, with a total of 5168 participants. Follow-up ranged front 1 to 10 years. Quantitative synthesis was limited by the heterogeneity of populations, settings, and interventions, and by the small number of studies that examined outcomes other than weight. Overall, compared to usual care, font Studies with a follow-up of 1 year reduced weight by 2.8 kg (95% confidence interval [CI] 1.0-4.7) (3.3% of baseline body weight) and decreased body mass index by 1.4 kg/m(2) (CI=0.5-2.3). Weight loss at 2 bears was 2.7 kg (CI=1.9-3.4) (two studies). Modest improvements were noted in the few studies that examined glycemic control, blood pressure, and lipid concentrations (p>0.05). The incidence of diabetes was significantly lower in the intervention groups versus the controls in three of five studies examining this outcome at 3 to 6 years follow-up. Conclusions: Overall, weight-loss strategies rising dietary, physical activity, or behavioral interventions produced significant improvements in weight among persons with pre-diabetes, and a significant decrease in diabetes incidence. Further work is needed on the long-term effects of these interventions on morbidity and mortality and on how to implement these interventions in the community setting. (C) 2005 American Journal of Preventive Medicine.

AB - Objective: To assess the effectiveness of weight-loss and weight-control interventions for adults with pre-diabetes (impaired fasting glucose and impaired glucose tolerance), an important risk factor for the development of type 2 diabetes. Methods: Computerized searches were conducted of multiple electronic bibliographic databases tip to August 2003. Randomized controlled trials in any language were selected that examined weight-loss or weight-control strategies rising at least one dietary, physical activity, or behavioral intervention, and with a follow-up interval of aparts per thousandY12 months. Effects were combined using a random effects model. Results: Studies were identified, with a total of 5168 participants. Follow-up ranged front 1 to 10 years. Quantitative synthesis was limited by the heterogeneity of populations, settings, and interventions, and by the small number of studies that examined outcomes other than weight. Overall, compared to usual care, font Studies with a follow-up of 1 year reduced weight by 2.8 kg (95% confidence interval [CI] 1.0-4.7) (3.3% of baseline body weight) and decreased body mass index by 1.4 kg/m(2) (CI=0.5-2.3). Weight loss at 2 bears was 2.7 kg (CI=1.9-3.4) (two studies). Modest improvements were noted in the few studies that examined glycemic control, blood pressure, and lipid concentrations (p>0.05). The incidence of diabetes was significantly lower in the intervention groups versus the controls in three of five studies examining this outcome at 3 to 6 years follow-up. Conclusions: Overall, weight-loss strategies rising dietary, physical activity, or behavioral interventions produced significant improvements in weight among persons with pre-diabetes, and a significant decrease in diabetes incidence. Further work is needed on the long-term effects of these interventions on morbidity and mortality and on how to implement these interventions in the community setting. (C) 2005 American Journal of Preventive Medicine.

KW - Impaired glucose-tolerance

KW - type 2 diabetes mellitus

KW - lifestyle intervention

KW - body fat distribution

KW - Da Qing IGT

KW - preventio program

KW - randomized trial

KW - glycemic control

KW - behavioral treatment

KW - insulin resistance

U2 - 10.1016/j.amepre.2004.08.006

DO - 10.1016/j.amepre.2004.08.006

M3 - Article

VL - 28

SP - 126

EP - 139

JO - American Journal of Preventive Medicine

JF - American Journal of Preventive Medicine

SN - 0749-3797

IS - 1

ER -