Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population

T Ando, M Minami, T Mizuno, O Watanabe, K Ishiguro, K Ina, K Kusugami, K Nobata, T Nishiwaki, T Tsuzuki, M Shimada, E El-Omar, H Goto

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Abstract

Background. The long-term benefit of Helicobacter pylori eradication treatment that includes metronidazole on peptic ulcer disease in Japan is unclear. We investigated the rate of H. pylori re-infection and ulcer relapse after H. pylori eradication.

Materials and methods. A total of 266 patients with endoscopically confirmed peptic ulcer disease and H. pylori infection were treated with triple therapy of omeprazole 40 mg (20 mg b.i.d.), clarithromycin 800 mg (400 mg b.i.d.), and tinidazole 1000 mg (500 mg b.i.d.) for 7 days. Endoscopy with gastric biopsy was performed before and 1 month, 6 months, 1.5 years, and 3.5 years after therapy. H. pylori status was determined by H. pylori culture, rapid urease test, and histopathology. C-13-urea breath test was done at 6 months after eradication therapy. Treatment was deemed successful when all tests were negative at 6 months after therapy by endoscopic biopsy.

Results. Successful H. pylori eradication was achieved in 262/266 (98.5%) patients with peptic ulcer. Total relapse of peptic ulcer occurred in 8/262 (3%) patients after eradication, with 3/262 (1.1%) occurring within 1.5 years after treatment and 5/262 (1.9%) within 3.5 years. All relapsed patients were found to be H. pylori-positive at the time of relapse. Of the 262 patients who experienced eradication, 20 (7.6%) were subsequently re-infected, six (2.3%) within 1.5 years and 14 (5.3%) within 3.5 years.

Conclusion. Triple therapy with omeprazole, clarithromycin, and tinidazole (OCT) is useful for H. pylori eradication in Japan, but there is an appreciable re-infection rate in this population.

Original languageEnglish
Pages (from-to)379-384
Number of pages6
JournalHelicobacter
Volume10
Publication statusPublished - 2005

Keywords

  • long-term follow-up
  • eradication
  • Helicobacter pylori
  • duodenal-ulcer disease
  • reinfection rate
  • triple therapy
  • peptic-ulcer
  • double-bind
  • recurrence
  • infection
  • metronidazole
  • recrudescence
  • epidemiology

Cite this

Ando, T., Minami, M., Mizuno, T., Watanabe, O., Ishiguro, K., Ina, K., ... Goto, H. (2005). Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population. Helicobacter, 10, 379-384.

Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population. / Ando, T ; Minami, M ; Mizuno, T ; Watanabe, O ; Ishiguro, K ; Ina, K ; Kusugami, K ; Nobata, K ; Nishiwaki, T ; Tsuzuki, T ; Shimada, M ; El-Omar, E ; Goto, H .

In: Helicobacter, Vol. 10, 2005, p. 379-384.

Research output: Contribution to journalArticle

Ando, T, Minami, M, Mizuno, T, Watanabe, O, Ishiguro, K, Ina, K, Kusugami, K, Nobata, K, Nishiwaki, T, Tsuzuki, T, Shimada, M, El-Omar, E & Goto, H 2005, 'Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population', Helicobacter, vol. 10, pp. 379-384.
Ando, T ; Minami, M ; Mizuno, T ; Watanabe, O ; Ishiguro, K ; Ina, K ; Kusugami, K ; Nobata, K ; Nishiwaki, T ; Tsuzuki, T ; Shimada, M ; El-Omar, E ; Goto, H . / Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population. In: Helicobacter. 2005 ; Vol. 10. pp. 379-384.
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title = "Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population",
abstract = "Background. The long-term benefit of Helicobacter pylori eradication treatment that includes metronidazole on peptic ulcer disease in Japan is unclear. We investigated the rate of H. pylori re-infection and ulcer relapse after H. pylori eradication.Materials and methods. A total of 266 patients with endoscopically confirmed peptic ulcer disease and H. pylori infection were treated with triple therapy of omeprazole 40 mg (20 mg b.i.d.), clarithromycin 800 mg (400 mg b.i.d.), and tinidazole 1000 mg (500 mg b.i.d.) for 7 days. Endoscopy with gastric biopsy was performed before and 1 month, 6 months, 1.5 years, and 3.5 years after therapy. H. pylori status was determined by H. pylori culture, rapid urease test, and histopathology. C-13-urea breath test was done at 6 months after eradication therapy. Treatment was deemed successful when all tests were negative at 6 months after therapy by endoscopic biopsy.Results. Successful H. pylori eradication was achieved in 262/266 (98.5{\%}) patients with peptic ulcer. Total relapse of peptic ulcer occurred in 8/262 (3{\%}) patients after eradication, with 3/262 (1.1{\%}) occurring within 1.5 years after treatment and 5/262 (1.9{\%}) within 3.5 years. All relapsed patients were found to be H. pylori-positive at the time of relapse. Of the 262 patients who experienced eradication, 20 (7.6{\%}) were subsequently re-infected, six (2.3{\%}) within 1.5 years and 14 (5.3{\%}) within 3.5 years.Conclusion. Triple therapy with omeprazole, clarithromycin, and tinidazole (OCT) is useful for H. pylori eradication in Japan, but there is an appreciable re-infection rate in this population.",
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author = "T Ando and M Minami and T Mizuno and O Watanabe and K Ishiguro and K Ina and K Kusugami and K Nobata and T Nishiwaki and T Tsuzuki and M Shimada and E El-Omar and H Goto",
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TY - JOUR

T1 - Long-term follow-up after eradication of Helicobacter pylori with omeprazole, clarithromycin, and tinidazole (OCT regimen) in a Japanese population

AU - Ando, T

AU - Minami, M

AU - Mizuno, T

AU - Watanabe, O

AU - Ishiguro, K

AU - Ina, K

AU - Kusugami, K

AU - Nobata, K

AU - Nishiwaki, T

AU - Tsuzuki, T

AU - Shimada, M

AU - El-Omar, E

AU - Goto, H

PY - 2005

Y1 - 2005

N2 - Background. The long-term benefit of Helicobacter pylori eradication treatment that includes metronidazole on peptic ulcer disease in Japan is unclear. We investigated the rate of H. pylori re-infection and ulcer relapse after H. pylori eradication.Materials and methods. A total of 266 patients with endoscopically confirmed peptic ulcer disease and H. pylori infection were treated with triple therapy of omeprazole 40 mg (20 mg b.i.d.), clarithromycin 800 mg (400 mg b.i.d.), and tinidazole 1000 mg (500 mg b.i.d.) for 7 days. Endoscopy with gastric biopsy was performed before and 1 month, 6 months, 1.5 years, and 3.5 years after therapy. H. pylori status was determined by H. pylori culture, rapid urease test, and histopathology. C-13-urea breath test was done at 6 months after eradication therapy. Treatment was deemed successful when all tests were negative at 6 months after therapy by endoscopic biopsy.Results. Successful H. pylori eradication was achieved in 262/266 (98.5%) patients with peptic ulcer. Total relapse of peptic ulcer occurred in 8/262 (3%) patients after eradication, with 3/262 (1.1%) occurring within 1.5 years after treatment and 5/262 (1.9%) within 3.5 years. All relapsed patients were found to be H. pylori-positive at the time of relapse. Of the 262 patients who experienced eradication, 20 (7.6%) were subsequently re-infected, six (2.3%) within 1.5 years and 14 (5.3%) within 3.5 years.Conclusion. Triple therapy with omeprazole, clarithromycin, and tinidazole (OCT) is useful for H. pylori eradication in Japan, but there is an appreciable re-infection rate in this population.

AB - Background. The long-term benefit of Helicobacter pylori eradication treatment that includes metronidazole on peptic ulcer disease in Japan is unclear. We investigated the rate of H. pylori re-infection and ulcer relapse after H. pylori eradication.Materials and methods. A total of 266 patients with endoscopically confirmed peptic ulcer disease and H. pylori infection were treated with triple therapy of omeprazole 40 mg (20 mg b.i.d.), clarithromycin 800 mg (400 mg b.i.d.), and tinidazole 1000 mg (500 mg b.i.d.) for 7 days. Endoscopy with gastric biopsy was performed before and 1 month, 6 months, 1.5 years, and 3.5 years after therapy. H. pylori status was determined by H. pylori culture, rapid urease test, and histopathology. C-13-urea breath test was done at 6 months after eradication therapy. Treatment was deemed successful when all tests were negative at 6 months after therapy by endoscopic biopsy.Results. Successful H. pylori eradication was achieved in 262/266 (98.5%) patients with peptic ulcer. Total relapse of peptic ulcer occurred in 8/262 (3%) patients after eradication, with 3/262 (1.1%) occurring within 1.5 years after treatment and 5/262 (1.9%) within 3.5 years. All relapsed patients were found to be H. pylori-positive at the time of relapse. Of the 262 patients who experienced eradication, 20 (7.6%) were subsequently re-infected, six (2.3%) within 1.5 years and 14 (5.3%) within 3.5 years.Conclusion. Triple therapy with omeprazole, clarithromycin, and tinidazole (OCT) is useful for H. pylori eradication in Japan, but there is an appreciable re-infection rate in this population.

KW - long-term follow-up

KW - eradication

KW - Helicobacter pylori

KW - duodenal-ulcer disease

KW - reinfection rate

KW - triple therapy

KW - peptic-ulcer

KW - double-bind

KW - recurrence

KW - infection

KW - metronidazole

KW - recrudescence

KW - epidemiology

M3 - Article

VL - 10

SP - 379

EP - 384

JO - Helicobacter

JF - Helicobacter

SN - 1083-4389

ER -