Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women

Mohamed Waseem Osman, Mintu Nath, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

AIM: A single-centre, prospective longitudinal study to assess changes in maternal arterial stiffness and cardiac output parameters among low-risk healthy pregnant women.

METHODOLOGY: Thirty low-risk, healthy, pregnant women attending their routine antenatal dating ultrasound scan were recruited. Non-invasive assessment of arterial stiffness and cardiac output was undertaken at five gestational windows from 11 to 40 weeks of pregnancy. Data were analysed using a linear mixed model incorporating time and other relevant predictors as fixed effects, and patient as a random effect.

RESULTS: Gestational age had a significant effect on all arterial stiffness parameters, including brachial augmentation index (AIx) (p = .001), aortic AIx (p = .002) and aortic pulse wave velocity (p = .002). The aortic AIx (%) reduced during pregnancy: the lowest mean (standard error, SE) was 4.07 (1.01) at 28 weeks before it increased to 7.04 (SE 1.64) at 40 weeks. Similarly, non-invasive assessments of cardiac output (p < .001), stroke volume (p = .014), heart rate (p < .001) and total peripheral resistance (p < .001) demonstrated significant changes with gestational age. Mean cardiac output (l/m) increased during pregnancy reaching a peak at 28 weeks gestation 6.66 (SE 0.28), but dropped thereafter to reach 5.71 (SE 0.25) around term.

CONCLUSION: The current study provides pregnancy normograms for gestational changes in arterial stiffness and cardiac output parameters among low-risk, healthy pregnant women. Further work will be required to assess the risk of placental mediated diseases and pregnancy outcome among pregnant women with parameters outside the normal range.

Original languageEnglish
Pages (from-to)256-261
Number of pages6
JournalPregnancy Hypertension
Volume10
Early online date16 Oct 2017
DOIs
Publication statusPublished - Oct 2017

Fingerprint

Vascular Stiffness
Cardiac Output
Longitudinal Studies
Pregnant Women
Pregnancy
Gestational Age
Placenta Diseases
Pulse Wave Analysis
Pregnancy Outcome
Vascular Resistance
Stroke Volume
Linear Models
Reference Values
Arm
Heart Rate
Mothers
Prospective Studies

Keywords

  • Adult
  • Aorta/physiology
  • Cardiac Output/physiology
  • Female
  • Humans
  • Longitudinal Studies
  • Pregnancy/physiology
  • Pregnancy Trimesters/physiology
  • Prospective Studies
  • Reference Values
  • Vascular Stiffness

Cite this

Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women. / Osman, Mohamed Waseem; Nath, Mintu; Khalil, Asma; Webb, David R; Robinson, Thompson G; Mousa, Hatem A.

In: Pregnancy Hypertension, Vol. 10, 10.2017, p. 256-261.

Research output: Contribution to journalArticle

Osman, Mohamed Waseem ; Nath, Mintu ; Khalil, Asma ; Webb, David R ; Robinson, Thompson G ; Mousa, Hatem A. / Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women. In: Pregnancy Hypertension. 2017 ; Vol. 10. pp. 256-261.
@article{be294a90b9284a208532373069674f12,
title = "Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women",
abstract = "AIM: A single-centre, prospective longitudinal study to assess changes in maternal arterial stiffness and cardiac output parameters among low-risk healthy pregnant women.METHODOLOGY: Thirty low-risk, healthy, pregnant women attending their routine antenatal dating ultrasound scan were recruited. Non-invasive assessment of arterial stiffness and cardiac output was undertaken at five gestational windows from 11 to 40 weeks of pregnancy. Data were analysed using a linear mixed model incorporating time and other relevant predictors as fixed effects, and patient as a random effect.RESULTS: Gestational age had a significant effect on all arterial stiffness parameters, including brachial augmentation index (AIx) (p = .001), aortic AIx (p = .002) and aortic pulse wave velocity (p = .002). The aortic AIx ({\%}) reduced during pregnancy: the lowest mean (standard error, SE) was 4.07 (1.01) at 28 weeks before it increased to 7.04 (SE 1.64) at 40 weeks. Similarly, non-invasive assessments of cardiac output (p < .001), stroke volume (p = .014), heart rate (p < .001) and total peripheral resistance (p < .001) demonstrated significant changes with gestational age. Mean cardiac output (l/m) increased during pregnancy reaching a peak at 28 weeks gestation 6.66 (SE 0.28), but dropped thereafter to reach 5.71 (SE 0.25) around term.CONCLUSION: The current study provides pregnancy normograms for gestational changes in arterial stiffness and cardiac output parameters among low-risk, healthy pregnant women. Further work will be required to assess the risk of placental mediated diseases and pregnancy outcome among pregnant women with parameters outside the normal range.",
keywords = "Adult, Aorta/physiology, Cardiac Output/physiology, Female, Humans, Longitudinal Studies, Pregnancy/physiology, Pregnancy Trimesters/physiology, Prospective Studies, Reference Values, Vascular Stiffness",
author = "Osman, {Mohamed Waseem} and Mintu Nath and Asma Khalil and Webb, {David R} and Robinson, {Thompson G} and Mousa, {Hatem A}",
note = "Copyright {\circledC} 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.",
year = "2017",
month = "10",
doi = "10.1016/j.preghy.2017.10.007",
language = "English",
volume = "10",
pages = "256--261",
journal = "Pregnancy Hypertension",
issn = "2210-7789",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Longitudinal study to assess changes in arterial stiffness and cardiac output parameters among low-risk pregnant women

AU - Osman, Mohamed Waseem

AU - Nath, Mintu

AU - Khalil, Asma

AU - Webb, David R

AU - Robinson, Thompson G

AU - Mousa, Hatem A

N1 - Copyright © 2017 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.

PY - 2017/10

Y1 - 2017/10

N2 - AIM: A single-centre, prospective longitudinal study to assess changes in maternal arterial stiffness and cardiac output parameters among low-risk healthy pregnant women.METHODOLOGY: Thirty low-risk, healthy, pregnant women attending their routine antenatal dating ultrasound scan were recruited. Non-invasive assessment of arterial stiffness and cardiac output was undertaken at five gestational windows from 11 to 40 weeks of pregnancy. Data were analysed using a linear mixed model incorporating time and other relevant predictors as fixed effects, and patient as a random effect.RESULTS: Gestational age had a significant effect on all arterial stiffness parameters, including brachial augmentation index (AIx) (p = .001), aortic AIx (p = .002) and aortic pulse wave velocity (p = .002). The aortic AIx (%) reduced during pregnancy: the lowest mean (standard error, SE) was 4.07 (1.01) at 28 weeks before it increased to 7.04 (SE 1.64) at 40 weeks. Similarly, non-invasive assessments of cardiac output (p < .001), stroke volume (p = .014), heart rate (p < .001) and total peripheral resistance (p < .001) demonstrated significant changes with gestational age. Mean cardiac output (l/m) increased during pregnancy reaching a peak at 28 weeks gestation 6.66 (SE 0.28), but dropped thereafter to reach 5.71 (SE 0.25) around term.CONCLUSION: The current study provides pregnancy normograms for gestational changes in arterial stiffness and cardiac output parameters among low-risk, healthy pregnant women. Further work will be required to assess the risk of placental mediated diseases and pregnancy outcome among pregnant women with parameters outside the normal range.

AB - AIM: A single-centre, prospective longitudinal study to assess changes in maternal arterial stiffness and cardiac output parameters among low-risk healthy pregnant women.METHODOLOGY: Thirty low-risk, healthy, pregnant women attending their routine antenatal dating ultrasound scan were recruited. Non-invasive assessment of arterial stiffness and cardiac output was undertaken at five gestational windows from 11 to 40 weeks of pregnancy. Data were analysed using a linear mixed model incorporating time and other relevant predictors as fixed effects, and patient as a random effect.RESULTS: Gestational age had a significant effect on all arterial stiffness parameters, including brachial augmentation index (AIx) (p = .001), aortic AIx (p = .002) and aortic pulse wave velocity (p = .002). The aortic AIx (%) reduced during pregnancy: the lowest mean (standard error, SE) was 4.07 (1.01) at 28 weeks before it increased to 7.04 (SE 1.64) at 40 weeks. Similarly, non-invasive assessments of cardiac output (p < .001), stroke volume (p = .014), heart rate (p < .001) and total peripheral resistance (p < .001) demonstrated significant changes with gestational age. Mean cardiac output (l/m) increased during pregnancy reaching a peak at 28 weeks gestation 6.66 (SE 0.28), but dropped thereafter to reach 5.71 (SE 0.25) around term.CONCLUSION: The current study provides pregnancy normograms for gestational changes in arterial stiffness and cardiac output parameters among low-risk, healthy pregnant women. Further work will be required to assess the risk of placental mediated diseases and pregnancy outcome among pregnant women with parameters outside the normal range.

KW - Adult

KW - Aorta/physiology

KW - Cardiac Output/physiology

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Pregnancy/physiology

KW - Pregnancy Trimesters/physiology

KW - Prospective Studies

KW - Reference Values

KW - Vascular Stiffness

UR - http://hdl.handle.net/2381/41684

U2 - 10.1016/j.preghy.2017.10.007

DO - 10.1016/j.preghy.2017.10.007

M3 - Article

VL - 10

SP - 256

EP - 261

JO - Pregnancy Hypertension

JF - Pregnancy Hypertension

SN - 2210-7789

ER -