Low-grade inflammation, diet composition and health

current research evidence and its translation

Anne M Minihane, Sophie Vinoy, Wendy R Russell, Athanasia Baka, Helen M Roche, Kieran M Tuohy, Jessica L Teeling, Ellen E Blaak, Michael Fenech, David Vauzour, Harry J McArdle, Bas H A Kremer, Luc Sterkman, Katerina Vafeiadou, Massimo Massi Benedetti, Christine M Williams, Philip C Calder

Research output: Contribution to journalArticle

141 Citations (Scopus)
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Abstract

The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled 'Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies'. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation-health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation-health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims.

Original languageEnglish
Pages (from-to)999-1012
Number of pages14
JournalBritish Journal of Nutrition
Volume114
Issue number07
Early online date31 Jul 2015
DOIs
Publication statusPublished - Oct 2015

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Diet
Inflammation
Health
Research
Aptitude
Biological Science Disciplines
Advisory Committees
Fasting
Obesity
Biomarkers
Pathology
Cytokines
Education

Keywords

  • low-grade inflammation
  • biomarkers
  • chronic diseases
  • health claims

Cite this

Low-grade inflammation, diet composition and health : current research evidence and its translation. / Minihane, Anne M; Vinoy, Sophie; Russell, Wendy R; Baka, Athanasia; Roche, Helen M; Tuohy, Kieran M; Teeling, Jessica L; Blaak, Ellen E; Fenech, Michael; Vauzour, David; McArdle, Harry J; Kremer, Bas H A; Sterkman, Luc; Vafeiadou, Katerina; Benedetti, Massimo Massi; Williams, Christine M; Calder, Philip C.

In: British Journal of Nutrition, Vol. 114, No. 07, 10.2015, p. 999-1012.

Research output: Contribution to journalArticle

Minihane, AM, Vinoy, S, Russell, WR, Baka, A, Roche, HM, Tuohy, KM, Teeling, JL, Blaak, EE, Fenech, M, Vauzour, D, McArdle, HJ, Kremer, BHA, Sterkman, L, Vafeiadou, K, Benedetti, MM, Williams, CM & Calder, PC 2015, 'Low-grade inflammation, diet composition and health: current research evidence and its translation', British Journal of Nutrition, vol. 114, no. 07, pp. 999-1012. https://doi.org/10.1017/S0007114515002093
Minihane, Anne M ; Vinoy, Sophie ; Russell, Wendy R ; Baka, Athanasia ; Roche, Helen M ; Tuohy, Kieran M ; Teeling, Jessica L ; Blaak, Ellen E ; Fenech, Michael ; Vauzour, David ; McArdle, Harry J ; Kremer, Bas H A ; Sterkman, Luc ; Vafeiadou, Katerina ; Benedetti, Massimo Massi ; Williams, Christine M ; Calder, Philip C. / Low-grade inflammation, diet composition and health : current research evidence and its translation. In: British Journal of Nutrition. 2015 ; Vol. 114, No. 07. pp. 999-1012.
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N1 - Acknowledgements The present review results from a workshop organised by the European Branch of ILSI Europe. This publication was coordinated by Dr Peter Putz, Scientific Project Manager at ILSI Europe. The workshop was funded by the ILSI Europe Obesity and Diabetes Task Force, the ILSI Europe Metabolic Imprinting Task Force, ILSI Brazil, ILSI North America and ILSI Southeast Asia Region. The authors thank the members of the Organising Committee: Professor Jean-Louis Bresson and Professor Ascension Marcos for their invaluable contribution to this work through their enthusiastic and generous participation. The authors are also grateful to Ms Belinda Antonio, Ms Toula Aslanidis, Ms Ruth Marquet, Mr Pierre Mouelhi and Mr Alex Rankin for their administrative support. The authors thank Dr Lorraine Gambling, Dr Helen Hayes and Ms Val Stevens for technical assistance.

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