Low-grade inflammation, diet composition and health: current research evidence and its translation

Anne M Minihane; Sophie Vinoy; Wendy R Russell; Athanasia Baka; Helen M Roche; Kieran M Tuohy; Jessica L Teeling; Ellen E Blaak; Michael Fenech; David Vauzour; Harry J McArdle; Bas H A Kremer; Luc Sterkman; Katerina Vafeiadou; Massimo Massi Benedetti; Christine M Williams; Philip C Calder

doi:10.1017/S0007114515002093

Low-grade inflammation, diet composition and health: current research evidence and its translation

Anne M Minihane, Sophie Vinoy, Wendy R Russell, Athanasia Baka, Helen M Roche, Kieran M Tuohy, Jessica L Teeling, Ellen E Blaak, Michael Fenech, David Vauzour, Harry J McArdle, Bas H A Kremer, Luc Sterkman, Katerina Vafeiadou, Massimo Massi Benedetti, Christine M Williams, Philip C Calder

The Rowett Institute of Nutrition and Health

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Abstract

The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled 'Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies'. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation-health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation-health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims.

Original language	English
Pages (from-to)	999-1012
Number of pages	14
Journal	British Journal of Nutrition
Volume	114
Issue number	07
Early online date	31 Jul 2015
DOIs	https://doi.org/10.1017/S0007114515002093
Publication status	Published - Oct 2015

Bibliographical note

Acknowledgements
The present review results from a workshop organised by the European Branch of ILSI Europe. This publication was coordinated by Dr Peter Putz, Scientific Project Manager at ILSI Europe. The workshop was funded by the ILSI Europe Obesity and Diabetes Task Force, the ILSI Europe Metabolic Imprinting Task Force, ILSI Brazil, ILSI North America and ILSI Southeast Asia Region.

The authors thank the members of the Organising Committee: Professor Jean-Louis Bresson and Professor Ascension Marcos for their invaluable contribution to this work through their enthusiastic and generous participation. The authors are also grateful to Ms Belinda Antonio, Ms Toula Aslanidis, Ms Ruth Marquet, Mr Pierre Mouelhi and Mr Alex Rankin for their administrative support. The authors thank Dr Lorraine Gambling, Dr Helen Hayes and Ms Val Stevens for technical assistance.

Keywords

low-grade inflammation
biomarkers
chronic diseases
health claims

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0007114515002093Licence: CC BY

Low-grade inflammation, diet composition and health
copyright ILSI Europe 2015. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:// creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 245 KBLicence: CC BY

Cite this

Minihane, A. M., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M., Vauzour, D., McArdle, H. J., Kremer, B. H. A., Sterkman, L., Vafeiadou, K., Benedetti, M. M., Williams, C. M., & Calder, P. C. (2015). Low-grade inflammation, diet composition and health: current research evidence and its translation. British Journal of Nutrition, 114(07), 999-1012. https://doi.org/10.1017/S0007114515002093

Minihane, AM, Vinoy, S, Russell, WR, Baka, A, Roche, HM, Tuohy, KM, Teeling, JL, Blaak, EE, Fenech, M, Vauzour, D, McArdle, HJ, Kremer, BHA, Sterkman, L, Vafeiadou, K, Benedetti, MM, Williams, CM & Calder, PC 2015, 'Low-grade inflammation, diet composition and health: current research evidence and its translation', British Journal of Nutrition, vol. 114, no. 07, pp. 999-1012. https://doi.org/10.1017/S0007114515002093

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abstract = "The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled 'Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies'. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation-health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation-health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims.",

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AU - Tuohy, Kieran M

AU - Teeling, Jessica L

AU - Blaak, Ellen E

AU - Fenech, Michael

AU - Vauzour, David

AU - McArdle, Harry J

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AU - Williams, Christine M

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N1 - Acknowledgements The present review results from a workshop organised by the European Branch of ILSI Europe. This publication was coordinated by Dr Peter Putz, Scientific Project Manager at ILSI Europe. The workshop was funded by the ILSI Europe Obesity and Diabetes Task Force, the ILSI Europe Metabolic Imprinting Task Force, ILSI Brazil, ILSI North America and ILSI Southeast Asia Region. The authors thank the members of the Organising Committee: Professor Jean-Louis Bresson and Professor Ascension Marcos for their invaluable contribution to this work through their enthusiastic and generous participation. The authors are also grateful to Ms Belinda Antonio, Ms Toula Aslanidis, Ms Ruth Marquet, Mr Pierre Mouelhi and Mr Alex Rankin for their administrative support. The authors thank Dr Lorraine Gambling, Dr Helen Hayes and Ms Val Stevens for technical assistance.

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AB - The importance of chronic low-grade inflammation in the pathology of numerous age-related chronic conditions is now clear. An unresolved inflammatory response is likely to be involved from the early stages of disease development. The present position paper is the most recent in a series produced by the International Life Sciences Institute's European Branch (ILSI Europe). It is co-authored by the speakers from a 2013 workshop led by the Obesity and Diabetes Task Force entitled 'Low-grade inflammation, a high-grade challenge: biomarkers and modulation by dietary strategies'. The latest research in the areas of acute and chronic inflammation and cardiometabolic, gut and cognitive health is presented along with the cellular and molecular mechanisms underlying inflammation-health/disease associations. The evidence relating diet composition and early-life nutrition to inflammatory status is reviewed. Human epidemiological and intervention data are thus far heavily reliant on the measurement of inflammatory markers in the circulation, and in particular cytokines in the fasting state, which are recognised as an insensitive and highly variable index of tissue inflammation. Potential novel kinetic and integrated approaches to capture inflammatory status in humans are discussed. Such approaches are likely to provide a more discriminating means of quantifying inflammation-health/disease associations, and the ability of diet to positively modulate inflammation and provide the much needed evidence to develop research portfolios that will inform new product development and associated health claims.

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DO - 10.1017/S0007114515002093

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JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 07

ER -

Low-grade inflammation, diet composition and health: current research evidence and its translation

Abstract

Bibliographical note

Keywords

UN SDGs

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