Making thiosulfate-disubstituted-amino-optionally substituted-phenyl-imino-optionally substituted-cyclohexadienylidene-N,N-disubstituted-ammoniums comprises carrying out nitrosyl reduction, thiosulfonic acid formation and oxidative coupling

James Peter Sinclair; Sarah Louise Nicoll; John M. D. Storey

Making thiosulfate-disubstituted-amino-optionally substituted-phenyl-imino-optionally substituted-cyclohexadienylidene-N,N-disubstituted-ammoniums comprises carrying out nitrosyl reduction, thiosulfonic acid formation and oxidative coupling

James Peter Sinclair (Inventor), Sarah Louise Nicoll (Inventor), John M. D. Storey (Inventor)

Chemistry

Research output: Patent

Abstract

Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc)
WO 2015052496 A1

Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as "diaminophenothiazinium compounds") including Methythioninium Chloride (MTC) (also known as Methylene Blue) are provided.

Original language	English
Patent number	WO2015052496 A1
Priority date	7/10/13
Publication status	Published - 16 Apr 2015

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Making thiosulfate-disubstituted-amino-optionally substituted-phenyl-imino-optionally substituted-cyclohexadienylidene-N,N-disubstituted-ammoniums comprises carrying out nitrosyl reduction, thiosulfonic acid formation and oxidative coupling. / Sinclair, James Peter (Inventor); Nicoll, Sarah Louise (Inventor); Storey, John M. D. (Inventor).
Patent No.: WO2015052496 A1. Apr 16, 2015.

Research output: Patent

Sinclair, James Peter (Inventor) ; Nicoll, Sarah Louise (Inventor) ; Storey, John M. D. (Inventor). / Making thiosulfate-disubstituted-amino-optionally substituted-phenyl-imino-optionally substituted-cyclohexadienylidene-N,N-disubstituted-ammoniums comprises carrying out nitrosyl reduction, thiosulfonic acid formation and oxidative coupling. Patent No.: WO2015052496 A1. Apr 16, 2015.

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abstract = "Methods of chemical synthesis of diaminophenothiazinium compounds including methylthioninium chloride (mtc) WO 2015052496 A1Methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as {"}diaminophenothiazinium compounds{"}) including Methythioninium Chloride (MTC) (also known as Methylene Blue) are provided.",

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