The invention provides labelled platform conjugates, comprising (i) a labelling platformn (such as a dendrimer or nanoparticle) and (ii) a target binding moiety, wherein the labelling platform has at least one positron emitter attached thereto. The conjugates can be used to flexibly label antibodies or the like, with the positron emitted being added as a simple final step to a positron emitter attachment site, which is a particular advantage when using short halt-life isotopes such as18F. The invention further provides processes and materials for use in preparing the conjugates, and methods of imaging employing them e.g. in Positron Emission Tomography (PET).
|Patent number||GB2467494 (A)|
|Publication status||Published - 2010|