Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality

Sohinee Bhattacharya; Geraldine McNeill; Edwin Amalraj Raja; Keith Allan; Heather Clark; Rebecca M Reynolds; Jane Norman; Philip C Hannaford

doi:10.1136/heartjnl-2015-308709

Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality

Sohinee Bhattacharya, Geraldine McNeill, Edwin Amalraj Raja, Keith Allan, Heather Clark, Rebecca M Reynolds, Jane Norman, Philip C Hannaford

University of Edinburgh

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

15 Downloads (Pure)

Abstract

Objective To examine the effect of maternal gestational weight gain (GWG) on adult offspring mortality, cardiovascular morbidity and cerebrovascular morbidity.

Methods The Aberdeen Children of the Nineteen Fifties (ACONF) is a population-based cohort of adults born in Aberdeen, Scotland between 1950 and 1956. GWG of the mothers of cohort members was extracted from original birth records and linked to the data on offspring morbidity and mortality up to 2011 obtained from Scottish national records. HRs for cardiovascular events and mortality in offspring according to maternal weight gain in pregnancy were estimated adjusting for maternal and offspring confounders using a restricted cubic spline model.

Results After exclusions, 3781 members of the original ACONF cohort were analysed. Of these, 103 (2.7%) had died, 169 (4.5%) had suffered at least one cardiovascular event and 73 (1.9%) had had a hospital admission for cerebrovascular disease. Maternal weight gain of 1 kg/week or more was associated with increased risk of cerebrovascular event in the offspring (adjusted HR 2.70 (95% CI 1.19 to 6.12)). There was no association seen between GWG and offspring's all-cause mortality or cardiovascular event. Adult offspring characteristics (smoking, body mass index (BMI) and diabetes) were strongly associated with each outcome.

Conclusions Maternal GWG above 0.9 kg/week may increase the risk of cerebrovascular disease in the adult offspring, but not all-cause mortality or cardiovascular disease. Health and lifestyle factors such as smoking, BMI and diabetes in the adult offspring had a stronger influence than maternal and birth characteristics on their mortality and morbidity.

Original language	English
Pages (from-to)	1456-1463
Number of pages	8
Journal	Heart
Volume	102
Issue number	18
Early online date	12 May 2016
DOIs	https://doi.org/10.1136/heartjnl-2015-308709
Publication status	Published - 30 Sept 2016

Bibliographical note

Funding: This research was supported by Chest Heart and Stroke Scotland (R10/A128)

Acknowledgements: The authors wish to thank and acknowledge the scientific input of Dr Nadeem Sarwar who led the funding application to carry out this research; Ms Katie Wilde and the Data Management Team, University of Aberdeen, for data extraction from the Aberdeen databases and Ms Lena Henderson from ISD Scotland for data linkage and extraction from SMR databases.

Keywords

pregnancy
heart disease
metabolic syndrome
cardiac risk factors and prevention
obesity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1136/heartjnl-2015-308709Licence: Unspecified

Accepted Manuscript
This article has been accepted for publication in Heart following peer review. The definitive copyedited, typeset version Bhattacharya, S, McNeill, G, Raja, EA, Allan, K, Clark, H, Reynolds, RM, Norman, J & Hannaford, PC 2016, 'Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality' Heart, vol 102, no. 18, pp. 1456-1463., is available online at doi:10.1136/heartjnl-2015-308709
Accepted author manuscript, 0.99 MBLicence: Unspecified

Aberdeen Maternity and Neonatal Databank
Bhattacharya, S. (Data Manager) & Wilde, K. (Supervisor), University of Aberdeen, 1986
http://www.abdn.ac.uk/iahs/research/obsgynae/amnd/overview.php and one more link, http://www.abdn.ac.uk/iahs/research/obsgynae/amnd/access.php (show fewer)
Dataset
Children of the 1950's study: Aberdeen birth cohort
Black, C. (Owner), Hannaford, P. (Owner) & Clark, H. (Data Manager), University of Aberdeen, 2004
https://www.abdn.ac.uk/birth-cohorts/1950s/ and one more link, https://www.abdn.ac.uk/birth-cohorts/1950s/for-researchers/data-access/ (show fewer)
Dataset

Geraldine McNeill
- School of Medicine, Medical Sciences & Nutrition, Applied Health Sciences - Emeritus Professor
Person: Honorary

Cite this

@article{e6709583e13b498d9277bf7406a6c7a4,

title = "Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality",

abstract = "Objective To examine the effect of maternal gestational weight gain (GWG) on adult offspring mortality, cardiovascular morbidity and cerebrovascular morbidity.Methods The Aberdeen Children of the Nineteen Fifties (ACONF) is a population-based cohort of adults born in Aberdeen, Scotland between 1950 and 1956. GWG of the mothers of cohort members was extracted from original birth records and linked to the data on offspring morbidity and mortality up to 2011 obtained from Scottish national records. HRs for cardiovascular events and mortality in offspring according to maternal weight gain in pregnancy were estimated adjusting for maternal and offspring confounders using a restricted cubic spline model.Results After exclusions, 3781 members of the original ACONF cohort were analysed. Of these, 103 (2.7%) had died, 169 (4.5%) had suffered at least one cardiovascular event and 73 (1.9%) had had a hospital admission for cerebrovascular disease. Maternal weight gain of 1 kg/week or more was associated with increased risk of cerebrovascular event in the offspring (adjusted HR 2.70 (95% CI 1.19 to 6.12)). There was no association seen between GWG and offspring's all-cause mortality or cardiovascular event. Adult offspring characteristics (smoking, body mass index (BMI) and diabetes) were strongly associated with each outcome.Conclusions Maternal GWG above 0.9 kg/week may increase the risk of cerebrovascular disease in the adult offspring, but not all-cause mortality or cardiovascular disease. Health and lifestyle factors such as smoking, BMI and diabetes in the adult offspring had a stronger influence than maternal and birth characteristics on their mortality and morbidity.",

keywords = "pregnancy, heart disease, metabolic syndrome, cardiac risk factors and prevention, obesity",

author = "Sohinee Bhattacharya and Geraldine McNeill and Raja, {Edwin Amalraj} and Keith Allan and Heather Clark and Reynolds, {Rebecca M} and Jane Norman and Hannaford, {Philip C}",

note = "Funding: This research was supported by Chest Heart and Stroke Scotland (R10/A128) Acknowledgements: The authors wish to thank and acknowledge the scientific input of Dr Nadeem Sarwar who led the funding application to carry out this research; Ms Katie Wilde and the Data Management Team, University of Aberdeen, for data extraction from the Aberdeen databases and Ms Lena Henderson from ISD Scotland for data linkage and extraction from SMR databases.",

year = "2016",

month = sep,

day = "30",

doi = "10.1136/heartjnl-2015-308709",

language = "English",

volume = "102",

pages = "1456--1463",

journal = "Heart",

issn = "1355-6037",

publisher = "BMJ Publishing Group",

number = "18",

}

TY - JOUR

T1 - Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality

AU - Bhattacharya, Sohinee

AU - McNeill, Geraldine

AU - Raja, Edwin Amalraj

AU - Allan, Keith

AU - Clark, Heather

AU - Reynolds, Rebecca M

AU - Norman, Jane

AU - Hannaford, Philip C

N1 - Funding: This research was supported by Chest Heart and Stroke Scotland (R10/A128) Acknowledgements: The authors wish to thank and acknowledge the scientific input of Dr Nadeem Sarwar who led the funding application to carry out this research; Ms Katie Wilde and the Data Management Team, University of Aberdeen, for data extraction from the Aberdeen databases and Ms Lena Henderson from ISD Scotland for data linkage and extraction from SMR databases.

PY - 2016/9/30

Y1 - 2016/9/30

N2 - Objective To examine the effect of maternal gestational weight gain (GWG) on adult offspring mortality, cardiovascular morbidity and cerebrovascular morbidity.Methods The Aberdeen Children of the Nineteen Fifties (ACONF) is a population-based cohort of adults born in Aberdeen, Scotland between 1950 and 1956. GWG of the mothers of cohort members was extracted from original birth records and linked to the data on offspring morbidity and mortality up to 2011 obtained from Scottish national records. HRs for cardiovascular events and mortality in offspring according to maternal weight gain in pregnancy were estimated adjusting for maternal and offspring confounders using a restricted cubic spline model.Results After exclusions, 3781 members of the original ACONF cohort were analysed. Of these, 103 (2.7%) had died, 169 (4.5%) had suffered at least one cardiovascular event and 73 (1.9%) had had a hospital admission for cerebrovascular disease. Maternal weight gain of 1 kg/week or more was associated with increased risk of cerebrovascular event in the offspring (adjusted HR 2.70 (95% CI 1.19 to 6.12)). There was no association seen between GWG and offspring's all-cause mortality or cardiovascular event. Adult offspring characteristics (smoking, body mass index (BMI) and diabetes) were strongly associated with each outcome.Conclusions Maternal GWG above 0.9 kg/week may increase the risk of cerebrovascular disease in the adult offspring, but not all-cause mortality or cardiovascular disease. Health and lifestyle factors such as smoking, BMI and diabetes in the adult offspring had a stronger influence than maternal and birth characteristics on their mortality and morbidity.

AB - Objective To examine the effect of maternal gestational weight gain (GWG) on adult offspring mortality, cardiovascular morbidity and cerebrovascular morbidity.Methods The Aberdeen Children of the Nineteen Fifties (ACONF) is a population-based cohort of adults born in Aberdeen, Scotland between 1950 and 1956. GWG of the mothers of cohort members was extracted from original birth records and linked to the data on offspring morbidity and mortality up to 2011 obtained from Scottish national records. HRs for cardiovascular events and mortality in offspring according to maternal weight gain in pregnancy were estimated adjusting for maternal and offspring confounders using a restricted cubic spline model.Results After exclusions, 3781 members of the original ACONF cohort were analysed. Of these, 103 (2.7%) had died, 169 (4.5%) had suffered at least one cardiovascular event and 73 (1.9%) had had a hospital admission for cerebrovascular disease. Maternal weight gain of 1 kg/week or more was associated with increased risk of cerebrovascular event in the offspring (adjusted HR 2.70 (95% CI 1.19 to 6.12)). There was no association seen between GWG and offspring's all-cause mortality or cardiovascular event. Adult offspring characteristics (smoking, body mass index (BMI) and diabetes) were strongly associated with each outcome.Conclusions Maternal GWG above 0.9 kg/week may increase the risk of cerebrovascular disease in the adult offspring, but not all-cause mortality or cardiovascular disease. Health and lifestyle factors such as smoking, BMI and diabetes in the adult offspring had a stronger influence than maternal and birth characteristics on their mortality and morbidity.

KW - pregnancy

KW - heart disease

KW - metabolic syndrome

KW - cardiac risk factors and prevention

KW - obesity

U2 - 10.1136/heartjnl-2015-308709

DO - 10.1136/heartjnl-2015-308709

M3 - Article

SN - 1355-6037

VL - 102

SP - 1456

EP - 1463

JO - Heart

JF - Heart

IS - 18

ER -

Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

Fingerprint

Datasets

Aberdeen Maternity and Neonatal Databank

Children of the 1950's study: Aberdeen birth cohort

Profiles

Geraldine McNeill

Cite this