Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality

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Abstract

Objective To examine the effect of maternal gestational weight gain (GWG) on adult offspring mortality, cardiovascular morbidity and cerebrovascular morbidity.

Methods The Aberdeen Children of the Nineteen Fifties (ACONF) is a population-based cohort of adults born in Aberdeen, Scotland between 1950 and 1956. GWG of the mothers of cohort members was extracted from original birth records and linked to the data on offspring morbidity and mortality up to 2011 obtained from Scottish national records. HRs for cardiovascular events and mortality in offspring according to maternal weight gain in pregnancy were estimated adjusting for maternal and offspring confounders using a restricted cubic spline model.

Results After exclusions, 3781 members of the original ACONF cohort were analysed. Of these, 103 (2.7%) had died, 169 (4.5%) had suffered at least one cardiovascular event and 73 (1.9%) had had a hospital admission for cerebrovascular disease. Maternal weight gain of 1 kg/week or more was associated with increased risk of cerebrovascular event in the offspring (adjusted HR 2.70 (95% CI 1.19 to 6.12)). There was no association seen between GWG and offspring's all-cause mortality or cardiovascular event. Adult offspring characteristics (smoking, body mass index (BMI) and diabetes) were strongly associated with each outcome.

Conclusions Maternal GWG above 0.9 kg/week may increase the risk of cerebrovascular disease in the adult offspring, but not all-cause mortality or cardiovascular disease. Health and lifestyle factors such as smoking, BMI and diabetes in the adult offspring had a stronger influence than maternal and birth characteristics on their mortality and morbidity.
Original languageEnglish
Pages (from-to)1456-1463
Number of pages8
JournalHeart
Volume102
Issue number18
Early online date12 May 2016
DOIs
Publication statusPublished - 30 Sep 2016

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Weight Gain
Cardiovascular Diseases
Mothers
Adult Children
Mortality
Morbidity
Cerebrovascular Disorders
Body Mass Index
Smoking
Birth Certificates
Scotland
Life Style
Parturition
Pregnancy
Health
Population

Keywords

  • pregnancy
  • heart disease
  • metabolic syndrome
  • cardiac risk factors and prevention
  • obesity

Cite this

Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality. / Bhattacharya, Sohinee; McNeill, Geraldine; Raja, Edwin Amalraj; Allan, Keith; Clark, Heather; Reynolds, Rebecca M; Norman, Jane; Hannaford, Philip C.

In: Heart, Vol. 102, No. 18, 30.09.2016, p. 1456-1463.

Research output: Contribution to journalArticle

@article{e6709583e13b498d9277bf7406a6c7a4,
title = "Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality",
abstract = "Objective To examine the effect of maternal gestational weight gain (GWG) on adult offspring mortality, cardiovascular morbidity and cerebrovascular morbidity.Methods The Aberdeen Children of the Nineteen Fifties (ACONF) is a population-based cohort of adults born in Aberdeen, Scotland between 1950 and 1956. GWG of the mothers of cohort members was extracted from original birth records and linked to the data on offspring morbidity and mortality up to 2011 obtained from Scottish national records. HRs for cardiovascular events and mortality in offspring according to maternal weight gain in pregnancy were estimated adjusting for maternal and offspring confounders using a restricted cubic spline model.Results After exclusions, 3781 members of the original ACONF cohort were analysed. Of these, 103 (2.7{\%}) had died, 169 (4.5{\%}) had suffered at least one cardiovascular event and 73 (1.9{\%}) had had a hospital admission for cerebrovascular disease. Maternal weight gain of 1 kg/week or more was associated with increased risk of cerebrovascular event in the offspring (adjusted HR 2.70 (95{\%} CI 1.19 to 6.12)). There was no association seen between GWG and offspring's all-cause mortality or cardiovascular event. Adult offspring characteristics (smoking, body mass index (BMI) and diabetes) were strongly associated with each outcome.Conclusions Maternal GWG above 0.9 kg/week may increase the risk of cerebrovascular disease in the adult offspring, but not all-cause mortality or cardiovascular disease. Health and lifestyle factors such as smoking, BMI and diabetes in the adult offspring had a stronger influence than maternal and birth characteristics on their mortality and morbidity.",
keywords = "pregnancy, heart disease, metabolic syndrome, cardiac risk factors and prevention, obesity",
author = "Sohinee Bhattacharya and Geraldine McNeill and Raja, {Edwin Amalraj} and Keith Allan and Heather Clark and Reynolds, {Rebecca M} and Jane Norman and Hannaford, {Philip C}",
note = "Funding: This research was supported by Chest Heart and Stroke Scotland (R10/A128)",
year = "2016",
month = "9",
day = "30",
doi = "10.1136/heartjnl-2015-308709",
language = "English",
volume = "102",
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T1 - Maternal gestational weight gain and offspring's risk of cardiovascular disease and mortality

AU - Bhattacharya, Sohinee

AU - McNeill, Geraldine

AU - Raja, Edwin Amalraj

AU - Allan, Keith

AU - Clark, Heather

AU - Reynolds, Rebecca M

AU - Norman, Jane

AU - Hannaford, Philip C

N1 - Funding: This research was supported by Chest Heart and Stroke Scotland (R10/A128)

PY - 2016/9/30

Y1 - 2016/9/30

N2 - Objective To examine the effect of maternal gestational weight gain (GWG) on adult offspring mortality, cardiovascular morbidity and cerebrovascular morbidity.Methods The Aberdeen Children of the Nineteen Fifties (ACONF) is a population-based cohort of adults born in Aberdeen, Scotland between 1950 and 1956. GWG of the mothers of cohort members was extracted from original birth records and linked to the data on offspring morbidity and mortality up to 2011 obtained from Scottish national records. HRs for cardiovascular events and mortality in offspring according to maternal weight gain in pregnancy were estimated adjusting for maternal and offspring confounders using a restricted cubic spline model.Results After exclusions, 3781 members of the original ACONF cohort were analysed. Of these, 103 (2.7%) had died, 169 (4.5%) had suffered at least one cardiovascular event and 73 (1.9%) had had a hospital admission for cerebrovascular disease. Maternal weight gain of 1 kg/week or more was associated with increased risk of cerebrovascular event in the offspring (adjusted HR 2.70 (95% CI 1.19 to 6.12)). There was no association seen between GWG and offspring's all-cause mortality or cardiovascular event. Adult offspring characteristics (smoking, body mass index (BMI) and diabetes) were strongly associated with each outcome.Conclusions Maternal GWG above 0.9 kg/week may increase the risk of cerebrovascular disease in the adult offspring, but not all-cause mortality or cardiovascular disease. Health and lifestyle factors such as smoking, BMI and diabetes in the adult offspring had a stronger influence than maternal and birth characteristics on their mortality and morbidity.

AB - Objective To examine the effect of maternal gestational weight gain (GWG) on adult offspring mortality, cardiovascular morbidity and cerebrovascular morbidity.Methods The Aberdeen Children of the Nineteen Fifties (ACONF) is a population-based cohort of adults born in Aberdeen, Scotland between 1950 and 1956. GWG of the mothers of cohort members was extracted from original birth records and linked to the data on offspring morbidity and mortality up to 2011 obtained from Scottish national records. HRs for cardiovascular events and mortality in offspring according to maternal weight gain in pregnancy were estimated adjusting for maternal and offspring confounders using a restricted cubic spline model.Results After exclusions, 3781 members of the original ACONF cohort were analysed. Of these, 103 (2.7%) had died, 169 (4.5%) had suffered at least one cardiovascular event and 73 (1.9%) had had a hospital admission for cerebrovascular disease. Maternal weight gain of 1 kg/week or more was associated with increased risk of cerebrovascular event in the offspring (adjusted HR 2.70 (95% CI 1.19 to 6.12)). There was no association seen between GWG and offspring's all-cause mortality or cardiovascular event. Adult offspring characteristics (smoking, body mass index (BMI) and diabetes) were strongly associated with each outcome.Conclusions Maternal GWG above 0.9 kg/week may increase the risk of cerebrovascular disease in the adult offspring, but not all-cause mortality or cardiovascular disease. Health and lifestyle factors such as smoking, BMI and diabetes in the adult offspring had a stronger influence than maternal and birth characteristics on their mortality and morbidity.

KW - pregnancy

KW - heart disease

KW - metabolic syndrome

KW - cardiac risk factors and prevention

KW - obesity

U2 - 10.1136/heartjnl-2015-308709

DO - 10.1136/heartjnl-2015-308709

M3 - Article

VL - 102

SP - 1456

EP - 1463

JO - Heart

JF - Heart

SN - 1355-6037

IS - 18

ER -