Maternal smoking and changes in drug metabolising enzymes in the human fetus

A. Zafeiri; P. Filis; U. Soffientini; B. Lucendo-Villarin; A. Douglas; S. Shaw; J. P. Iredale; M. J. Swortwood; M. A. Huestis; M. Bellingham; R. T. Mitchell; D. C. Hays; P. J. O'Shaughnessy; P. A. Fowler

doi:10.1016/j.toxlet.2018.06.648

Maternal smoking and changes in drug metabolising enzymes in the human fetus

A. Zafeiri^* (Corresponding Author), P. Filis, U. Soffientini, B. Lucendo-Villarin, A. Douglas, S. Shaw, J. P. Iredale, M. J. Swortwood, M. A. Huestis, M. Bellingham, R. T. Mitchell, D. C. Hays, P. J. O'Shaughnessy, P. A. Fowler

^*Corresponding author for this work

Research output: Contribution to journal › Abstract › peer-review

Abstract

The placental feto-maternal interface allows for most drugs to freely diffuse and reach the developing fetus. Major phase I and II metabolising enzymes are expressed in the human fetal liver which is the primary site for metabolism of drug compounds. Maternal smoking passes ∼7,000 toxicants to the fetus, and is associated with multiple adverse consequences for peri/post-natal health and wellbeing in the offspring. Disruption of the drug metabolising machinery in the fetal liver also poses risks for drug toxicity. This study analysed drug metabolising enzymes (DME) expression levels in smoke-exposed human fetuses.

Original language	English
Article number	P06-28
Pages (from-to)	S114
Number of pages	1
Journal	Toxicology Letters
Volume	295
Issue number	Supplement 1
Early online date	12 Sept 2018
DOIs	https://doi.org/10.1016/j.toxlet.2018.06.648
Publication status	Published - 10 Oct 2018
Event	54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box - Brussels, Belgium Duration: 2 Sept 2018 → 5 Sept 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.toxlet.2018.06.648

Cite this

Zafeiri, A., Filis, P., Soffientini, U., Lucendo-Villarin, B., Douglas, A., Shaw, S., Iredale, J. P., Swortwood, M. J., Huestis, M. A., Bellingham, M., Mitchell, R. T., Hays, D. C., O'Shaughnessy, P. J., & Fowler, P. A. (2018). Maternal smoking and changes in drug metabolising enzymes in the human fetus. Toxicology Letters, 295(Supplement 1), S114. Article P06-28. https://doi.org/10.1016/j.toxlet.2018.06.648

Zafeiri, A, Filis, P, Soffientini, U, Lucendo-Villarin, B, Douglas, A, Shaw, S, Iredale, JP, Swortwood, MJ, Huestis, MA, Bellingham, M, Mitchell, RT, Hays, DC, O'Shaughnessy, PJ & Fowler, PA 2018, 'Maternal smoking and changes in drug metabolising enzymes in the human fetus', Toxicology Letters, vol. 295, no. Supplement 1, P06-28, pp. S114. https://doi.org/10.1016/j.toxlet.2018.06.648

@article{a42f4bac7be64d2ebb0add5392d4df7b,

title = "Maternal smoking and changes in drug metabolising enzymes in the human fetus",

abstract = "The placental feto-maternal interface allows for most drugs to freely diffuse and reach the developing fetus. Major phase I and II metabolising enzymes are expressed in the human fetal liver which is the primary site for metabolism of drug compounds. Maternal smoking passes ∼7,000 toxicants to the fetus, and is associated with multiple adverse consequences for peri/post-natal health and wellbeing in the offspring. Disruption of the drug metabolising machinery in the fetal liver also poses risks for drug toxicity. This study analysed drug metabolising enzymes (DME) expression levels in smoke-exposed human fetuses.",

author = "A. Zafeiri and P. Filis and U. Soffientini and B. Lucendo-Villarin and A. Douglas and S. Shaw and Iredale, {J. P.} and Swortwood, {M. J.} and Huestis, {M. A.} and M. Bellingham and Mitchell, {R. T.} and Hays, {D. C.} and O'Shaughnessy, {P. J.} and Fowler, {P. A.}",

year = "2018",

month = oct,

day = "10",

doi = "10.1016/j.toxlet.2018.06.648",

language = "English",

volume = "295",

pages = "S114",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

number = "Supplement 1",

note = "54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box ; Conference date: 02-09-2018 Through 05-09-2018",

}

TY - JOUR

T1 - Maternal smoking and changes in drug metabolising enzymes in the human fetus

AU - Zafeiri, A.

AU - Filis, P.

AU - Soffientini, U.

AU - Lucendo-Villarin, B.

AU - Douglas, A.

AU - Shaw, S.

AU - Iredale, J. P.

AU - Swortwood, M. J.

AU - Huestis, M. A.

AU - Bellingham, M.

AU - Mitchell, R. T.

AU - Hays, D. C.

AU - O'Shaughnessy, P. J.

AU - Fowler, P. A.

PY - 2018/10/10

Y1 - 2018/10/10

N2 - The placental feto-maternal interface allows for most drugs to freely diffuse and reach the developing fetus. Major phase I and II metabolising enzymes are expressed in the human fetal liver which is the primary site for metabolism of drug compounds. Maternal smoking passes ∼7,000 toxicants to the fetus, and is associated with multiple adverse consequences for peri/post-natal health and wellbeing in the offspring. Disruption of the drug metabolising machinery in the fetal liver also poses risks for drug toxicity. This study analysed drug metabolising enzymes (DME) expression levels in smoke-exposed human fetuses.

AB - The placental feto-maternal interface allows for most drugs to freely diffuse and reach the developing fetus. Major phase I and II metabolising enzymes are expressed in the human fetal liver which is the primary site for metabolism of drug compounds. Maternal smoking passes ∼7,000 toxicants to the fetus, and is associated with multiple adverse consequences for peri/post-natal health and wellbeing in the offspring. Disruption of the drug metabolising machinery in the fetal liver also poses risks for drug toxicity. This study analysed drug metabolising enzymes (DME) expression levels in smoke-exposed human fetuses.

U2 - 10.1016/j.toxlet.2018.06.648

DO - 10.1016/j.toxlet.2018.06.648

M3 - Abstract

SN - 0378-4274

VL - 295

SP - S114

JO - Toxicology Letters

JF - Toxicology Letters

IS - Supplement 1

M1 - P06-28

T2 - 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box

Y2 - 2 September 2018 through 5 September 2018

ER -

Maternal smoking and changes in drug metabolising enzymes in the human fetus

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this