We consider continuous and pulsed chemotherapy to destroy glioma cells without harming a large number of neurons and we computed the values of the infusion of chemotherapy agents in which the glioma is suppressed and a minimum number of neurons is lost, without neurogenesis.
The main contribution of this work is the insertion of a new differential equation to the model formulated in 2015 by Iarosz and collaborators. The new equation extend the mathematical model of brain tumour growth and and enables the study of sensitive and resistant glioma cells.
|Number of pages||10|
|Journal||Communications in Nonlinear Science & Numerical Simulation|
|Early online date||31 Aug 2021|
|Publication status||E-pub ahead of print - 31 Aug 2021|
- drug resistance
- glia-neuron interaction