Matrix metalloproteinase-9 concentrations in critically ill patients

K. A. Yassen, Helen Frances Galley, Nigel Robert Webster

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Matrix metalloproteinase-9 is involved in the processing of cytokines during sepsis. We studied 10 critically ill patients within 12 h of fulfilling the American Consensus Conference criteria for severe sepsis and compared the results with 12 critically ill non-septic control patients and eight healthy subjects. Total matrix metalloproteinase-9 concentrations were measured on days 1, 2 and 3. The median admission Acute Physiological and Chronic Health Evaluation II score was 19.5 (range 13-27) in the septic patients and 20.5 (range 7-28) in the non-septic patients. Four patients from each group died within 28 days. Matrix metalloproteinase-9 concentrations were elevated significantly in both groups of patients compared with healthy subjects (p = 0.0004) but there was no difference between patients with and without sepsis. Matrix metalloproteinase-9 levels did not change with time, and there was no difference between survivors and those who died. We conclude that matrix metalloproteinase-9 represents a non-specific market of systemic inflammation.

Original languageEnglish
Pages (from-to)729-732
Number of pages3
JournalAnaesthesia
Volume56
Issue number8
DOIs
Publication statusPublished - 2001

Keywords

  • critical care, sepsis
  • metalloproteinase
  • cytokine
  • TUMOR-NECROSIS-FACTOR
  • SEPTIC SHOCK
  • ALPHA
  • MORTALITY
  • DISEASE

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