Measurement of blood flow in tibial fracture patients using positron emission tomography

George Patrick Ashcroft, N T Evans, D Roeda, M Dodd, J R Mallard, R W Porter, F W Smith

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

The quantification of local bone blood flow in man has not previously been possible, despite its importance in the study of normal and pathological bone. We report the use of positron emission tomography, using 15O-labelled water, to measure bone blood flow in patients with closed unilateral fractures of the tibia. We compared fractured and unfractured limbs; alterations in blood flow paralleled those found in animal models. There was increased tibial blood flow at the fracture site as early as 24 hours after fracture, reaching up to 14 times that in the normal limb at two weeks. Blood flow increase was less in displaced than in undisplaced fractures. The muscle to bone ratios of blood flow were similar to those in previous animal work using other techniques. Positron emission tomography will allow study of human bone blood flow in vivo in a wide variety of pathological conditions.
Original languageEnglish
Pages (from-to)673-7
Number of pages5
JournalThe Journal of Bone and Joint Surgery - British volume
Volume74
Issue number5
Publication statusPublished - 1992

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Tibial Fractures
Positron-Emission Tomography
Bone and Bones
Extremities
Closed Fractures
Tibia
Animal Models
Muscles
Water

Cite this

Ashcroft, G. P., Evans, N. T., Roeda, D., Dodd, M., Mallard, J. R., Porter, R. W., & Smith, F. W. (1992). Measurement of blood flow in tibial fracture patients using positron emission tomography. The Journal of Bone and Joint Surgery - British volume , 74(5), 673-7.

Measurement of blood flow in tibial fracture patients using positron emission tomography. / Ashcroft, George Patrick; Evans, N T; Roeda, D; Dodd, M; Mallard, J R; Porter, R W; Smith, F W.

In: The Journal of Bone and Joint Surgery - British volume , Vol. 74, No. 5, 1992, p. 673-7.

Research output: Contribution to journalArticle

Ashcroft, GP, Evans, NT, Roeda, D, Dodd, M, Mallard, JR, Porter, RW & Smith, FW 1992, 'Measurement of blood flow in tibial fracture patients using positron emission tomography', The Journal of Bone and Joint Surgery - British volume , vol. 74, no. 5, pp. 673-7.
Ashcroft, George Patrick ; Evans, N T ; Roeda, D ; Dodd, M ; Mallard, J R ; Porter, R W ; Smith, F W. / Measurement of blood flow in tibial fracture patients using positron emission tomography. In: The Journal of Bone and Joint Surgery - British volume . 1992 ; Vol. 74, No. 5. pp. 673-7.
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