Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography

G F Keenan, G P Ashcroft, G H Roditi, J D Hutchison, N T Evans, P Mikecz, F Chaloner, M Dodd, C Leonard, R W Porter

Research output: Contribution to journalArticle

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Abstract

Study Design. Ten subjects (seven with neurogenic claudication and three control subjects) underwent examination of lower limb muscle blood flow before and after exercise using positron emission tomography.

Objectives. To investigate the hypothesis that lower limb muscle ischemia was the origin of symptoms in neurogenic claudication.

Background. Patients with neurogenic claudication secondary to spinal stenosis experience lower limb discomfort after exercise similar to that of ischemic claudication. However, they do not have clinical evidence of peripheral vascular disease. The authors postulated that the lower limb discomfort in patients with neurogenic claudication may arise from muscle ischemia due to inadequate dilatation of arterioles in response to exercise, this itself arising secondary to sympathetic dysfunction due to spinal stenosis.

Method. Using O-15-labeled water and positron emission tomography measured thigh and leg muscle blood flow response to exercise bilaterally in seven patients with unilateral neurogenic claudication and three control subjects were measured.

Results. The average values obtained for mid-thigh and mid-calf muscle perfusion at rest were 2.57 ml/min/100 g tissue (2.23-3.90) and 2.39 ml/min/100 g tissue (2.03-3.46), respectively. The average valued obtained from mid-thigh and mid-calf perfusion after exercise were 4.41 ml/min/100 g tissue (2.8-6.0) and 4.87 ml/min/100 g (2.2-11.7). We found no difference in muscle perfusion between symptomatic and asymptomatic limbs in this group of patients.

Conclusion. These studies suggest that muscle ischemia is not the origin of symptoms in most patients with neurogenic claudication.

Original languageEnglish
Pages (from-to)408-411
Number of pages4
JournalSpine
Volume20
Issue number4
Publication statusPublished - 15 Feb 1995

Keywords

  • Adult
  • Aged
  • Female
  • Humans
  • Leg
  • Male
  • Middle Aged
  • Muscles
  • Nervous System Diseases
  • Pain
  • Physical Exertion
  • Regional Blood Flow
  • Tomography, Emission-Computed
  • Neurogenic Claudication
  • Pathophysiology
  • Muscle blood flow
  • Positron emission Tomography

Cite this

Keenan, G. F., Ashcroft, G. P., Roditi, G. H., Hutchison, J. D., Evans, N. T., Mikecz, P., ... Porter, R. W. (1995). Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography. Spine, 20(4), 408-411.

Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography. / Keenan, G F; Ashcroft, G P; Roditi, G H; Hutchison, J D; Evans, N T; Mikecz, P; Chaloner, F; Dodd, M; Leonard, C; Porter, R W.

In: Spine, Vol. 20, No. 4, 15.02.1995, p. 408-411.

Research output: Contribution to journalArticle

Keenan, GF, Ashcroft, GP, Roditi, GH, Hutchison, JD, Evans, NT, Mikecz, P, Chaloner, F, Dodd, M, Leonard, C & Porter, RW 1995, 'Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography', Spine, vol. 20, no. 4, pp. 408-411.
Keenan GF, Ashcroft GP, Roditi GH, Hutchison JD, Evans NT, Mikecz P et al. Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography. Spine. 1995 Feb 15;20(4):408-411.
Keenan, G F ; Ashcroft, G P ; Roditi, G H ; Hutchison, J D ; Evans, N T ; Mikecz, P ; Chaloner, F ; Dodd, M ; Leonard, C ; Porter, R W. / Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography. In: Spine. 1995 ; Vol. 20, No. 4. pp. 408-411.
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abstract = "Study Design. Ten subjects (seven with neurogenic claudication and three control subjects) underwent examination of lower limb muscle blood flow before and after exercise using positron emission tomography.Objectives. To investigate the hypothesis that lower limb muscle ischemia was the origin of symptoms in neurogenic claudication.Background. Patients with neurogenic claudication secondary to spinal stenosis experience lower limb discomfort after exercise similar to that of ischemic claudication. However, they do not have clinical evidence of peripheral vascular disease. The authors postulated that the lower limb discomfort in patients with neurogenic claudication may arise from muscle ischemia due to inadequate dilatation of arterioles in response to exercise, this itself arising secondary to sympathetic dysfunction due to spinal stenosis.Method. Using O-15-labeled water and positron emission tomography measured thigh and leg muscle blood flow response to exercise bilaterally in seven patients with unilateral neurogenic claudication and three control subjects were measured.Results. The average values obtained for mid-thigh and mid-calf muscle perfusion at rest were 2.57 ml/min/100 g tissue (2.23-3.90) and 2.39 ml/min/100 g tissue (2.03-3.46), respectively. The average valued obtained from mid-thigh and mid-calf perfusion after exercise were 4.41 ml/min/100 g tissue (2.8-6.0) and 4.87 ml/min/100 g (2.2-11.7). We found no difference in muscle perfusion between symptomatic and asymptomatic limbs in this group of patients.Conclusion. These studies suggest that muscle ischemia is not the origin of symptoms in most patients with neurogenic claudication.",
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T1 - Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography

AU - Keenan, G F

AU - Ashcroft, G P

AU - Roditi, G H

AU - Hutchison, J D

AU - Evans, N T

AU - Mikecz, P

AU - Chaloner, F

AU - Dodd, M

AU - Leonard, C

AU - Porter, R W

PY - 1995/2/15

Y1 - 1995/2/15

N2 - Study Design. Ten subjects (seven with neurogenic claudication and three control subjects) underwent examination of lower limb muscle blood flow before and after exercise using positron emission tomography.Objectives. To investigate the hypothesis that lower limb muscle ischemia was the origin of symptoms in neurogenic claudication.Background. Patients with neurogenic claudication secondary to spinal stenosis experience lower limb discomfort after exercise similar to that of ischemic claudication. However, they do not have clinical evidence of peripheral vascular disease. The authors postulated that the lower limb discomfort in patients with neurogenic claudication may arise from muscle ischemia due to inadequate dilatation of arterioles in response to exercise, this itself arising secondary to sympathetic dysfunction due to spinal stenosis.Method. Using O-15-labeled water and positron emission tomography measured thigh and leg muscle blood flow response to exercise bilaterally in seven patients with unilateral neurogenic claudication and three control subjects were measured.Results. The average values obtained for mid-thigh and mid-calf muscle perfusion at rest were 2.57 ml/min/100 g tissue (2.23-3.90) and 2.39 ml/min/100 g tissue (2.03-3.46), respectively. The average valued obtained from mid-thigh and mid-calf perfusion after exercise were 4.41 ml/min/100 g tissue (2.8-6.0) and 4.87 ml/min/100 g (2.2-11.7). We found no difference in muscle perfusion between symptomatic and asymptomatic limbs in this group of patients.Conclusion. These studies suggest that muscle ischemia is not the origin of symptoms in most patients with neurogenic claudication.

AB - Study Design. Ten subjects (seven with neurogenic claudication and three control subjects) underwent examination of lower limb muscle blood flow before and after exercise using positron emission tomography.Objectives. To investigate the hypothesis that lower limb muscle ischemia was the origin of symptoms in neurogenic claudication.Background. Patients with neurogenic claudication secondary to spinal stenosis experience lower limb discomfort after exercise similar to that of ischemic claudication. However, they do not have clinical evidence of peripheral vascular disease. The authors postulated that the lower limb discomfort in patients with neurogenic claudication may arise from muscle ischemia due to inadequate dilatation of arterioles in response to exercise, this itself arising secondary to sympathetic dysfunction due to spinal stenosis.Method. Using O-15-labeled water and positron emission tomography measured thigh and leg muscle blood flow response to exercise bilaterally in seven patients with unilateral neurogenic claudication and three control subjects were measured.Results. The average values obtained for mid-thigh and mid-calf muscle perfusion at rest were 2.57 ml/min/100 g tissue (2.23-3.90) and 2.39 ml/min/100 g tissue (2.03-3.46), respectively. The average valued obtained from mid-thigh and mid-calf perfusion after exercise were 4.41 ml/min/100 g tissue (2.8-6.0) and 4.87 ml/min/100 g (2.2-11.7). We found no difference in muscle perfusion between symptomatic and asymptomatic limbs in this group of patients.Conclusion. These studies suggest that muscle ischemia is not the origin of symptoms in most patients with neurogenic claudication.

KW - Adult

KW - Aged

KW - Female

KW - Humans

KW - Leg

KW - Male

KW - Middle Aged

KW - Muscles

KW - Nervous System Diseases

KW - Pain

KW - Physical Exertion

KW - Regional Blood Flow

KW - Tomography, Emission-Computed

KW - Neurogenic Claudication

KW - Pathophysiology

KW - Muscle blood flow

KW - Positron emission Tomography

M3 - Article

VL - 20

SP - 408

EP - 411

JO - Spine

JF - Spine

SN - 0362-2436

IS - 4

ER -