Abstract
1. The rate of substrate cycling between acetate and acetyl-CoA in sheep hindlimb muscle was measured from the decrease of [14C]acetate specific radioactivity across the tissue in vivo. 2. The rate of cycling was 0.005-0.015 mumol/min per g and, in two of the three sheep investigated, was approximately doubled as a result of infusing 2 mol acetate/day intravenously. 3. The results indicate that this cycle contributes only approx. 0.5% of the total heat produced by the animal and would probably make only a relatively small contribution to any heat increment of feeding associated with diets producing large amounts of acetate.
Original language | English |
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Pages (from-to) | 821-827 |
Number of pages | 7 |
Journal | Biochemical Journal |
Volume | 243 |
Issue number | 3 |
DOIs | |
Publication status | Published - 1 May 1987 |
Keywords
- Acetic Acid
- Acetic Acids
- Acetyl Coenzyme A
- Animals
- Body Temperature Regulation
- Citric Acid Cycle
- Male
- Muscles
- Sheep