Quantitative estimation of neuroreceptor occupancy by exogenous drugs using positron emission tomography is based on the reduction in the total volume of distribution (VT) of site-specific radioligands after drug administration. An estimate of the distribution volume of free and nonspecifically bound radioligand (VND) is also required to distinguish specific from total binding. However, a true reference region, devoid of specific binding, is often not available. We present a transformation of a graphical method, originally introduced by Lassen, using regional estimates of VT alone to determine occupancy, together with an extension that does not require baseline data.
|Number of pages||5|
|Journal||Journal of Cerebral Blood Flow and Metabolism|
|Early online date||9 Sep 2009|
|Publication status||Published - Jan 2010|
- graphical analysis
- brain transfer constants
- time uptake data