Meeting the fetal requirement for polyunsaturated fatty acids in pregnancy

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    Purpose of review

    The aim of this review is to summarize recent evidence on the importance of individual long chain polyunsaturated fatty acid (LCPUFA) to the developing fetus and the maternal dietary requirement for these.

    Recent findings

    Large-scale randomized controlled trials and innovative genetic and stable isotope studies are providing new insights in this field.

    Summary

    Large randomized controlled trials of LCPUFA supplementation in pregnancy suggest that higher n-3 LCPUFA intake reduces the risk of preterm birth and increases the length of gestation, with secondary effects on birth weight. There is little evidence of an effect on postnatal visual function and cognition, but interpretation is complicated by maternal metabolic adaptations and adipose tissue status in the newborn. The links between polymorphisms in the FADS genes and tissue fatty acid composition suggest that LCPUFA synthesis influences overall availability. Stable isotope studies have also demonstrated the capacity for LCPUFA synthesis in pregnancy, the fact that n-6 synthesis is greater than n-3, metabolic channeling of individual fatty acids to different fates, and selective placental transfer. Studies linking FADS genotype to cognition imply that n-3 LCPUFA synthesis could have an effect on infant cognition, but more large-scale genetic studies are needed.
    Original languageEnglish
    Pages (from-to)151-155
    Number of pages5
    JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
    Volume17
    Issue number2
    DOIs
    Publication statusPublished - Mar 2014

    Fingerprint

    Unsaturated Fatty Acids
    Pregnancy
    Cognition
    Isotopes
    Fatty Acids
    Randomized Controlled Trials
    Mothers
    Nutritional Requirements
    Premature Birth
    Birth Weight
    Adipose Tissue
    Fetus
    Genotype
    Newborn Infant
    Genes

    Cite this

    Meeting the fetal requirement for polyunsaturated fatty acids in pregnancy. / Haggarty, Paul.

    In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 17, No. 2, 03.2014, p. 151-155.

    Research output: Contribution to journalArticle

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