Mercury Toxicity and Speciation Analysis

Eva M. Krupp*, Zuzana Gajdosechova, Tanja Schwerdtle, Hanna Lohren

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

To understand the kinetics and toxic mechanisms of mercury (Hg) species in vivo and in vitro, speciation analysis is of important relevance. This chapter focuses on the identification of thiol and/or selenol containing target biomolecules. Recent in vitro studies comparing the transfer across brain barriers as well as the toxicity in human neurons and human astrocytes clearly demonstrate strong variations between inorganic mercuric Hg chloride (HgCl2) and organic methylmercury chloride (MeHgCl) and thiomersal illustrating the need for speciation analysis. Most often, mercury speciation analysis uses hyphenated systems comprising of a separation technique coupled to elementor molecule-selective detection. Main analyzers for Hg are inductively coupled plasma-mass spectrometry (ICP-MS), cold vapor-atomic fluorescence spectrometry (CV-AFS), microwave-induced plasma-atomic emission (MIP-AES) and ICP-atomic emission spectrometry (ICP-AES). Today, a wide variety of instrumentation for total Hg analysis exists, for example, with CV-AFS providing ppt-level limits of detection.

Original languageEnglish
Title of host publicationMetallomics Analytical Techniques and Speciation Methods
EditorsBernhard Michalke
PublisherWiley-VCH Verlag
Pages285-304
Number of pages20
ISBN (Electronic)9783527694907
ISBN (Print)9783527339693
DOIs
Publication statusPublished - 23 Sep 2016

Fingerprint

Mercury
Spectrometry
Toxicity
Fluorescence
Vapors
Thimerosal
Inductively coupled plasma mass spectrometry
Mercuric Chloride
Poisons
Inductively coupled plasma
Biomolecules
Sulfhydryl Compounds
Neurons
Chlorides
Brain
Microwaves
Plasmas
Molecules
Kinetics

Keywords

  • Cold vapor-atomic fluorescence spectrometry
  • Inductively coupled plasma-mass spectrometry
  • Mercury speciation analysis
  • Mercury toxicity
  • Microwave-induced plasma-atomic emission
  • Thiol identification

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Krupp, E. M., Gajdosechova, Z., Schwerdtle, T., & Lohren, H. (2016). Mercury Toxicity and Speciation Analysis. In B. Michalke (Ed.), Metallomics Analytical Techniques and Speciation Methods (pp. 285-304). Wiley-VCH Verlag. https://doi.org/10.1002/9783527694907.ch9

Mercury Toxicity and Speciation Analysis. / Krupp, Eva M.; Gajdosechova, Zuzana; Schwerdtle, Tanja; Lohren, Hanna.

Metallomics Analytical Techniques and Speciation Methods. ed. / Bernhard Michalke . Wiley-VCH Verlag, 2016. p. 285-304.

Research output: Chapter in Book/Report/Conference proceedingChapter

Krupp, EM, Gajdosechova, Z, Schwerdtle, T & Lohren, H 2016, Mercury Toxicity and Speciation Analysis. in B Michalke (ed.), Metallomics Analytical Techniques and Speciation Methods. Wiley-VCH Verlag, pp. 285-304. https://doi.org/10.1002/9783527694907.ch9
Krupp EM, Gajdosechova Z, Schwerdtle T, Lohren H. Mercury Toxicity and Speciation Analysis. In Michalke B, editor, Metallomics Analytical Techniques and Speciation Methods. Wiley-VCH Verlag. 2016. p. 285-304 https://doi.org/10.1002/9783527694907.ch9
Krupp, Eva M. ; Gajdosechova, Zuzana ; Schwerdtle, Tanja ; Lohren, Hanna. / Mercury Toxicity and Speciation Analysis. Metallomics Analytical Techniques and Speciation Methods. editor / Bernhard Michalke . Wiley-VCH Verlag, 2016. pp. 285-304
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