Metabolic costs of force generation for constant-frequency and catchlike-inducing electrical stimulation in human tibialis anterior muscle

Aivaras Ratkevicius, B. Quistorff

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Metabolic costs of force generation were compared for constant-frequency and catchlike-inducing electrical stimulation. Repetitive catchlike-inducing trains consisted of 2 interpulse intervals (IPIs) at 12.5 ms, 1 IPI at 25 ms, and 5 IPIs at 50 ms. Constant-frequency trains consisted of 8 IPIs at 37.5 ms. One train was delivered to the peroneal nerve every 2.5 s for 36 times under ischemic conditions. Anaerobic adenosine triphosphate (ATP) turnover was determined using 31-phosphorus magnetic resonance spectroscopy (P-MRS) of the human tibialis anterior muscle. Compared with constant-frequency trains, catchlike-inducing trains produced a faster force generation and were more effective in maintaining the force-time integral as well as peak force. However, ATP costs of force generation were similar for the catchlike-inducing and constant-frequency stimulation (6.7 +/- 1.1 and 6.6 +/- 1.0 mumol ATP/kg wet weight/N(.)s, respectively, P = 0.601). This suggests that the positive effects of catchlike-inducing stimulation on force maintenance are mediated by potentiated Ca2+ release from the sarcoplasmic reticulum rather than by lower metabolic costs of muscle force generation. Our findings also suggest that catchlike-inducing stimulation produces larger forces in fatigued muscle than constant-frequency trains and thus may be beneficial for muscle training or rehabilitation when muscle loading needs to be maintained in repetitive contractions. (C) 2002 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)419-426
Number of pages7
JournalMuscle & nerve
Volume25
Issue number3
DOIs
Publication statusPublished - Mar 2002

Keywords

  • electrical stimulation
  • energy metabolism
  • muscle contraction
  • muscle fatigue
  • nuclear magnetic resonance
  • HUMAN SKELETAL-MUSCLE
  • SINGLE MOTOR UNITS
  • HUMAN CALF
  • FATIGUE
  • CONTRACTIONS
  • RECOVERY
  • EXERCISE
  • ACTIVATION
  • PATTERN
  • FIBERS

Cite this

Metabolic costs of force generation for constant-frequency and catchlike-inducing electrical stimulation in human tibialis anterior muscle. / Ratkevicius, Aivaras; Quistorff, B.

In: Muscle & nerve, Vol. 25, No. 3, 03.2002, p. 419-426.

Research output: Contribution to journalArticle

@article{1d7ea06d5b804bfb8b76bb4079af521b,
title = "Metabolic costs of force generation for constant-frequency and catchlike-inducing electrical stimulation in human tibialis anterior muscle",
abstract = "Metabolic costs of force generation were compared for constant-frequency and catchlike-inducing electrical stimulation. Repetitive catchlike-inducing trains consisted of 2 interpulse intervals (IPIs) at 12.5 ms, 1 IPI at 25 ms, and 5 IPIs at 50 ms. Constant-frequency trains consisted of 8 IPIs at 37.5 ms. One train was delivered to the peroneal nerve every 2.5 s for 36 times under ischemic conditions. Anaerobic adenosine triphosphate (ATP) turnover was determined using 31-phosphorus magnetic resonance spectroscopy (P-MRS) of the human tibialis anterior muscle. Compared with constant-frequency trains, catchlike-inducing trains produced a faster force generation and were more effective in maintaining the force-time integral as well as peak force. However, ATP costs of force generation were similar for the catchlike-inducing and constant-frequency stimulation (6.7 +/- 1.1 and 6.6 +/- 1.0 mumol ATP/kg wet weight/N(.)s, respectively, P = 0.601). This suggests that the positive effects of catchlike-inducing stimulation on force maintenance are mediated by potentiated Ca2+ release from the sarcoplasmic reticulum rather than by lower metabolic costs of muscle force generation. Our findings also suggest that catchlike-inducing stimulation produces larger forces in fatigued muscle than constant-frequency trains and thus may be beneficial for muscle training or rehabilitation when muscle loading needs to be maintained in repetitive contractions. (C) 2002 Wiley Periodicals, Inc.",
keywords = "electrical stimulation, energy metabolism, muscle contraction, muscle fatigue, nuclear magnetic resonance, HUMAN SKELETAL-MUSCLE, SINGLE MOTOR UNITS, HUMAN CALF, FATIGUE, CONTRACTIONS, RECOVERY, EXERCISE, ACTIVATION, PATTERN, FIBERS",
author = "Aivaras Ratkevicius and B. Quistorff",
year = "2002",
month = "3",
doi = "10.1002/mus.10064",
language = "English",
volume = "25",
pages = "419--426",
journal = "Muscle & nerve",
issn = "0148-639X",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Metabolic costs of force generation for constant-frequency and catchlike-inducing electrical stimulation in human tibialis anterior muscle

AU - Ratkevicius, Aivaras

AU - Quistorff, B.

PY - 2002/3

Y1 - 2002/3

N2 - Metabolic costs of force generation were compared for constant-frequency and catchlike-inducing electrical stimulation. Repetitive catchlike-inducing trains consisted of 2 interpulse intervals (IPIs) at 12.5 ms, 1 IPI at 25 ms, and 5 IPIs at 50 ms. Constant-frequency trains consisted of 8 IPIs at 37.5 ms. One train was delivered to the peroneal nerve every 2.5 s for 36 times under ischemic conditions. Anaerobic adenosine triphosphate (ATP) turnover was determined using 31-phosphorus magnetic resonance spectroscopy (P-MRS) of the human tibialis anterior muscle. Compared with constant-frequency trains, catchlike-inducing trains produced a faster force generation and were more effective in maintaining the force-time integral as well as peak force. However, ATP costs of force generation were similar for the catchlike-inducing and constant-frequency stimulation (6.7 +/- 1.1 and 6.6 +/- 1.0 mumol ATP/kg wet weight/N(.)s, respectively, P = 0.601). This suggests that the positive effects of catchlike-inducing stimulation on force maintenance are mediated by potentiated Ca2+ release from the sarcoplasmic reticulum rather than by lower metabolic costs of muscle force generation. Our findings also suggest that catchlike-inducing stimulation produces larger forces in fatigued muscle than constant-frequency trains and thus may be beneficial for muscle training or rehabilitation when muscle loading needs to be maintained in repetitive contractions. (C) 2002 Wiley Periodicals, Inc.

AB - Metabolic costs of force generation were compared for constant-frequency and catchlike-inducing electrical stimulation. Repetitive catchlike-inducing trains consisted of 2 interpulse intervals (IPIs) at 12.5 ms, 1 IPI at 25 ms, and 5 IPIs at 50 ms. Constant-frequency trains consisted of 8 IPIs at 37.5 ms. One train was delivered to the peroneal nerve every 2.5 s for 36 times under ischemic conditions. Anaerobic adenosine triphosphate (ATP) turnover was determined using 31-phosphorus magnetic resonance spectroscopy (P-MRS) of the human tibialis anterior muscle. Compared with constant-frequency trains, catchlike-inducing trains produced a faster force generation and were more effective in maintaining the force-time integral as well as peak force. However, ATP costs of force generation were similar for the catchlike-inducing and constant-frequency stimulation (6.7 +/- 1.1 and 6.6 +/- 1.0 mumol ATP/kg wet weight/N(.)s, respectively, P = 0.601). This suggests that the positive effects of catchlike-inducing stimulation on force maintenance are mediated by potentiated Ca2+ release from the sarcoplasmic reticulum rather than by lower metabolic costs of muscle force generation. Our findings also suggest that catchlike-inducing stimulation produces larger forces in fatigued muscle than constant-frequency trains and thus may be beneficial for muscle training or rehabilitation when muscle loading needs to be maintained in repetitive contractions. (C) 2002 Wiley Periodicals, Inc.

KW - electrical stimulation

KW - energy metabolism

KW - muscle contraction

KW - muscle fatigue

KW - nuclear magnetic resonance

KW - HUMAN SKELETAL-MUSCLE

KW - SINGLE MOTOR UNITS

KW - HUMAN CALF

KW - FATIGUE

KW - CONTRACTIONS

KW - RECOVERY

KW - EXERCISE

KW - ACTIVATION

KW - PATTERN

KW - FIBERS

U2 - 10.1002/mus.10064

DO - 10.1002/mus.10064

M3 - Article

VL - 25

SP - 419

EP - 426

JO - Muscle & nerve

JF - Muscle & nerve

SN - 0148-639X

IS - 3

ER -