Modelling the associations between fat-free mass, resting metabolic rate and energy intake in the context of total energy balance

M. Hopkins, G. Finlayson, C. Duarte, S. Whybrow, P. Ritz, G. W. Horgan, J. E. Blundell, R. J. Stubbs

Research output: Contribution to journalArticle

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Abstract

Background: The relationship between body composition, energy expenditure and ad libitum energy intake (EI) has rarely been examined under conditions that allow any interplay between these variables to be disclosed.
Objective: The present study examined the relationships between body composition, energy expenditure and EI under controlled laboratory conditions in which the energy density and macronutrient content of the diet varied freely as a function of food choice.
Methods: Fifty-nine subjects (30 men: mean body mass index=26.7±4.0 kg m−2; 29 women: mean body mass index=25.4±3.5 kg m−2) completed a 14-day stay in a residential feeding behaviour suite. During days 1 and 2, subjects consumed a fixed diet designed to maintain energy balance. On days 3–14, food intake was covertly measured in subjects who had ad libitum access to a wide variety of foods typical of their normal diets. Resting metabolic rate (RMR; respiratory exchange), total daily energy expenditure (doubly labelled water) and body composition (total body water estimated from deuterium dilution) were measured on days 3–14.
Results: Hierarchical multiple regression indicated that after controlling for age and sex, both fat-free mass (FFM; P<0.001) and RMR (P<0.001) predicted daily EI. However, a mediation model using path analysis indicated that the effect of FFM (and fat mass) on EI was fully mediated by RMR (P<0.001).
Conclusions: These data indicate that RMR is a strong determinant of EI under controlled laboratory conditions where food choice is allowed to freely vary and subjects are close to energy balance. Therefore, the conventional adipocentric model of appetite control should be revised to reflect the influence of RMR.
Original languageEnglish
Pages (from-to)312-318
Number of pages7
JournalInternational Journal of Obesity
Volume40
Issue number2
Early online date15 Sep 2015
DOIs
Publication statusPublished - Feb 2016

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Energy Intake
Fats
Body Composition
Energy Metabolism
Diet
Food
Body Mass Index
Body Water
Deuterium
Feeding Behavior
Appetite
Eating
Water

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Modelling the associations between fat-free mass, resting metabolic rate and energy intake in the context of total energy balance. / Hopkins, M.; Finlayson, G.; Duarte, C.; Whybrow, S.; Ritz, P.; Horgan, G. W.; Blundell, J. E.; Stubbs, R. J.

In: International Journal of Obesity, Vol. 40, No. 2, 02.2016, p. 312-318.

Research output: Contribution to journalArticle

Hopkins, M. ; Finlayson, G. ; Duarte, C. ; Whybrow, S. ; Ritz, P. ; Horgan, G. W. ; Blundell, J. E. ; Stubbs, R. J. / Modelling the associations between fat-free mass, resting metabolic rate and energy intake in the context of total energy balance. In: International Journal of Obesity. 2016 ; Vol. 40, No. 2. pp. 312-318.
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note = "ACKNOWLEDGEMENTS RJS is partly employed by Slimming World. GWH is funded by the Scottish Government's Rural and Environment Science and Analytical Services Division. JB, GF and MH acknowledge the support of the Biosciences and Biotechnology Research Council (BBSRC) grants BBS/B/05079 and BB/G005524/1. CD is supported by a PhD grant (SFRH/BD/76858/2011), sponsored by FCT (Portuguese Foundation for Science and Technology).",
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T1 - Modelling the associations between fat-free mass, resting metabolic rate and energy intake in the context of total energy balance

AU - Hopkins, M.

AU - Finlayson, G.

AU - Duarte, C.

AU - Whybrow, S.

AU - Ritz, P.

AU - Horgan, G. W.

AU - Blundell, J. E.

AU - Stubbs, R. J.

N1 - ACKNOWLEDGEMENTS RJS is partly employed by Slimming World. GWH is funded by the Scottish Government's Rural and Environment Science and Analytical Services Division. JB, GF and MH acknowledge the support of the Biosciences and Biotechnology Research Council (BBSRC) grants BBS/B/05079 and BB/G005524/1. CD is supported by a PhD grant (SFRH/BD/76858/2011), sponsored by FCT (Portuguese Foundation for Science and Technology).

PY - 2016/2

Y1 - 2016/2

N2 - Background: The relationship between body composition, energy expenditure and ad libitum energy intake (EI) has rarely been examined under conditions that allow any interplay between these variables to be disclosed.Objective: The present study examined the relationships between body composition, energy expenditure and EI under controlled laboratory conditions in which the energy density and macronutrient content of the diet varied freely as a function of food choice.Methods: Fifty-nine subjects (30 men: mean body mass index=26.7±4.0 kg m−2; 29 women: mean body mass index=25.4±3.5 kg m−2) completed a 14-day stay in a residential feeding behaviour suite. During days 1 and 2, subjects consumed a fixed diet designed to maintain energy balance. On days 3–14, food intake was covertly measured in subjects who had ad libitum access to a wide variety of foods typical of their normal diets. Resting metabolic rate (RMR; respiratory exchange), total daily energy expenditure (doubly labelled water) and body composition (total body water estimated from deuterium dilution) were measured on days 3–14.Results: Hierarchical multiple regression indicated that after controlling for age and sex, both fat-free mass (FFM; P<0.001) and RMR (P<0.001) predicted daily EI. However, a mediation model using path analysis indicated that the effect of FFM (and fat mass) on EI was fully mediated by RMR (P<0.001).Conclusions: These data indicate that RMR is a strong determinant of EI under controlled laboratory conditions where food choice is allowed to freely vary and subjects are close to energy balance. Therefore, the conventional adipocentric model of appetite control should be revised to reflect the influence of RMR.

AB - Background: The relationship between body composition, energy expenditure and ad libitum energy intake (EI) has rarely been examined under conditions that allow any interplay between these variables to be disclosed.Objective: The present study examined the relationships between body composition, energy expenditure and EI under controlled laboratory conditions in which the energy density and macronutrient content of the diet varied freely as a function of food choice.Methods: Fifty-nine subjects (30 men: mean body mass index=26.7±4.0 kg m−2; 29 women: mean body mass index=25.4±3.5 kg m−2) completed a 14-day stay in a residential feeding behaviour suite. During days 1 and 2, subjects consumed a fixed diet designed to maintain energy balance. On days 3–14, food intake was covertly measured in subjects who had ad libitum access to a wide variety of foods typical of their normal diets. Resting metabolic rate (RMR; respiratory exchange), total daily energy expenditure (doubly labelled water) and body composition (total body water estimated from deuterium dilution) were measured on days 3–14.Results: Hierarchical multiple regression indicated that after controlling for age and sex, both fat-free mass (FFM; P<0.001) and RMR (P<0.001) predicted daily EI. However, a mediation model using path analysis indicated that the effect of FFM (and fat mass) on EI was fully mediated by RMR (P<0.001).Conclusions: These data indicate that RMR is a strong determinant of EI under controlled laboratory conditions where food choice is allowed to freely vary and subjects are close to energy balance. Therefore, the conventional adipocentric model of appetite control should be revised to reflect the influence of RMR.

U2 - 10.1038/ijo.2015.155

DO - 10.1038/ijo.2015.155

M3 - Article

VL - 40

SP - 312

EP - 318

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 2

ER -