Moderate physical activity may prevent cartilage loss in women with knee osteoarthritis: data from the Osteoarthritis Initiative

Alessio Bricca; Wolfgang Wirth; Carsten B. Juhl; Jana Kemnitz; David J. Hunter; C. Kent Kwoh; Felix Eckstein; Adam G. Culvenor

doi:10.1002/acr.23791

Moderate physical activity may prevent cartilage loss in women with knee osteoarthritis: data from the Osteoarthritis Initiative

Alessio Bricca (Corresponding Author), Wolfgang Wirth, Carsten B. Juhl, Jana Kemnitz, David J. Hunter, C. Kent Kwoh, Felix Eckstein, Adam G. Culvenor

Research output: Contribution to journal › Article › peer-review

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Abstract

Objective
To examine the impact of physical activity (PA) on cartilage thickness loss in knee osteoarthritis (KOA).

Methods
689 participants with radiographic KOA (Kellgren/Lawrence grade ≥2) at baseline, from the Osteoarthritis Initiative completed the Physical Activity Scale for the Elderly (PASE) questionnaires at annual intervals over four years. Magnetic resonance imaging‐based cartilage thickness change in the medial femorotibial compartment (MFTC) over four years was the main outcome. The impact of PASE tertiles (low, moderate, high) on changes in MFTC cartilage thickness was estimated using a mixed effect model adjusted for baseline characteristics. Furthermore, straficiation by sex was performed for secondary analyses.

Results
Structural progression of MFTC cartilage loss of ‐0.20 mm (95% confidence interval: ‐0.22 to ‐0.17mm) was observed in the entire cohort, with no statistically significant difference between PA levels after adjustment for baseline characteristics. A sex‐by‐physical activity interaction was observed in the adjusted analysis (p=0.02). Stratification by sex showed that women with low PA had a statistically greater cartilage loss than women with moderate PA level (adjusted between group difference ‐0.09 mm [‐0.16 to ‐0.02 mm]), whereas no significant differences were observed in men.

Conclusion
While physical activity was not associated with cartilage thickness loss in the whole cohort, this relationship significantly differed between sexes. In women, but not in men, moderate PA may slow down structural disease progression compared to low PA levels. For both men and women, high PA does not appear to be more detrimental than lower PA levels for cartilage thickness loss.

Original language	English
Pages (from-to)	218-226
Number of pages	9
Journal	Arthritis Care & Research
Volume	71
Issue number	2
Early online date	19 Oct 2018
DOIs	https://doi.org/10.1002/acr.23791
Publication status	Published - 1 Feb 2019

Keywords

physical activity
cartilage
load
thickness
osteoarthritis
PROGRESSION DATA
T2 MEASUREMENTS
RISK
FEMOROTIBIAL CARTILAGE
ASYMPTOMATIC SUBJECTS
ELDERLY PASE
THICKNESS CHANGE
RELAXATION-TIMES
ACTIVITY SCALE
ASSOCIATION

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Accepted Manuscript
This is the peer reviewed version of the following article: Bricca, A. , Wirth, W. , Juhl, C. B., Kemnitz, J. , Hunter, D. J., Kwoh, C. K., Eckstein, F. and Culvenor, A. G. (2019), Moderate Physical Activity and Prevention of Cartilage Loss in People With Knee Osteoarthritis: Data From the Osteoarthritis Initiative. Arthritis Care Res, 71: 218-226., which has been published in final form at https://doi.org/10.1002/acr.23791. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Accepted author manuscript, 481 KBLicence: Unspecified

http://www.mendeley.com/research/moderate-physical-activity-prevention-cartilage-loss-people-knee-osteoarthritis-data-osteoarthritis

Cite this

@article{69b155eb6c394ab594b2aedbf80040f9,

title = "Moderate physical activity may prevent cartilage loss in women with knee osteoarthritis: data from the Osteoarthritis Initiative",

abstract = "ObjectiveTo examine the impact of physical activity (PA) on cartilage thickness loss in knee osteoarthritis (KOA).Methods689 participants with radiographic KOA (Kellgren/Lawrence grade ≥2) at baseline, from the Osteoarthritis Initiative completed the Physical Activity Scale for the Elderly (PASE) questionnaires at annual intervals over four years. Magnetic resonance imaging‐based cartilage thickness change in the medial femorotibial compartment (MFTC) over four years was the main outcome. The impact of PASE tertiles (low, moderate, high) on changes in MFTC cartilage thickness was estimated using a mixed effect model adjusted for baseline characteristics. Furthermore, straficiation by sex was performed for secondary analyses.ResultsStructural progression of MFTC cartilage loss of ‐0.20 mm (95% confidence interval: ‐0.22 to ‐0.17mm) was observed in the entire cohort, with no statistically significant difference between PA levels after adjustment for baseline characteristics. A sex‐by‐physical activity interaction was observed in the adjusted analysis (p=0.02). Stratification by sex showed that women with low PA had a statistically greater cartilage loss than women with moderate PA level (adjusted between group difference ‐0.09 mm [‐0.16 to ‐0.02 mm]), whereas no significant differences were observed in men.ConclusionWhile physical activity was not associated with cartilage thickness loss in the whole cohort, this relationship significantly differed between sexes. In women, but not in men, moderate PA may slow down structural disease progression compared to low PA levels. For both men and women, high PA does not appear to be more detrimental than lower PA levels for cartilage thickness loss.",

keywords = "physical activity, cartilage, load, thickness, osteoarthritis, PROGRESSION DATA, T2 MEASUREMENTS, RISK, FEMOROTIBIAL CARTILAGE, ASYMPTOMATIC SUBJECTS, ELDERLY PASE, THICKNESS CHANGE, RELAXATION-TIMES, ACTIVITY SCALE, ASSOCIATION",

author = "Alessio Bricca and Wolfgang Wirth and Juhl, {Carsten B.} and Jana Kemnitz and Hunter, {David J.} and Kwoh, {C. Kent} and Felix Eckstein and Culvenor, {Adam G.}",

note = "All authors have completed the ICMJE uniform disclosure form at http://www.icmje.org/coi_disclosure.pdf and declare: data acquisition in this study was funded by the Osteoarthritis Initiative, a public–private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259;N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the Osteoarthritis Initiative study Investigators. Private funding partners of the OAI include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the Osteoarthritis Initiative is managed by the Foundation for the National Institutes of Health. The image analysis in this study was partly funded by the FNIH OA Biomarkers Consortium, with grants, direct and in -kind contributions, provided by: AbbVie; Amgen Inc.; Arthritis Foundation; Bioiberica S.A.; DePuy Mitek, Inc.; Flexion Therapeutics, Inc.; GlaxoSmithKline; Merck KGaA; Rottapharm | Madaus; Sanofi; and Stryker. Other parts of funding were provided by a direct grant from Merck KGaA, by a contract with the University of Pittsburgh (Pivotal OAI MRI Analyses [POMA]: NIH/NHLBI Contract No. HHSN2682010000 21C), by a vendor contract from the OAI coordinating center at University of California, San Francisco (N01-AR-2-2258), and by an ancillary study to the OAI held by the Division of Rheumatology, Feinberg School of Medicine, Northwestern University (R01 AR52918). This research has also received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) under grant agreement number 607510. AGC is supported by a National Health and Medical Research Council (NHMRC) of Australia Early Career Fellowship (Neil Hamilton Fairley Clinical Fellowship No.1121173). The sponsors were not involved in the design and conduct of this particular study, in the analysis and interpretation of the data, and in the preparation, review, or approval of the manuscript.",

year = "2019",

month = feb,

day = "1",

doi = "10.1002/acr.23791",

language = "English",

volume = "71",

pages = "218--226",

journal = "Arthritis Care & Research",

issn = "0893-7524",

publisher = "Wiley-Blackwell ",

number = "2",

}

TY - JOUR

T1 - Moderate physical activity may prevent cartilage loss in women with knee osteoarthritis

T2 - data from the Osteoarthritis Initiative

AU - Bricca, Alessio

AU - Wirth, Wolfgang

AU - Juhl, Carsten B.

AU - Kemnitz, Jana

AU - Hunter, David J.

AU - Kwoh, C. Kent

AU - Eckstein, Felix

AU - Culvenor, Adam G.

N1 - All authors have completed the ICMJE uniform disclosure form at http://www.icmje.org/coi_disclosure.pdf and declare: data acquisition in this study was funded by the Osteoarthritis Initiative, a public–private partnership comprised of five contracts (N01-AR-2-2258; N01-AR-2-2259;N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health, a branch of the Department of Health and Human Services, and conducted by the Osteoarthritis Initiative study Investigators. Private funding partners of the OAI include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the Osteoarthritis Initiative is managed by the Foundation for the National Institutes of Health. The image analysis in this study was partly funded by the FNIH OA Biomarkers Consortium, with grants, direct and in -kind contributions, provided by: AbbVie; Amgen Inc.; Arthritis Foundation; Bioiberica S.A.; DePuy Mitek, Inc.; Flexion Therapeutics, Inc.; GlaxoSmithKline; Merck KGaA; Rottapharm | Madaus; Sanofi; and Stryker. Other parts of funding were provided by a direct grant from Merck KGaA, by a contract with the University of Pittsburgh (Pivotal OAI MRI Analyses [POMA]: NIH/NHLBI Contract No. HHSN2682010000 21C), by a vendor contract from the OAI coordinating center at University of California, San Francisco (N01-AR-2-2258), and by an ancillary study to the OAI held by the Division of Rheumatology, Feinberg School of Medicine, Northwestern University (R01 AR52918). This research has also received funding from the European Union Seventh Framework Programme (FP7-PEOPLE-2013-ITN; KNEEMO) under grant agreement number 607510. AGC is supported by a National Health and Medical Research Council (NHMRC) of Australia Early Career Fellowship (Neil Hamilton Fairley Clinical Fellowship No.1121173). The sponsors were not involved in the design and conduct of this particular study, in the analysis and interpretation of the data, and in the preparation, review, or approval of the manuscript.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - ObjectiveTo examine the impact of physical activity (PA) on cartilage thickness loss in knee osteoarthritis (KOA).Methods689 participants with radiographic KOA (Kellgren/Lawrence grade ≥2) at baseline, from the Osteoarthritis Initiative completed the Physical Activity Scale for the Elderly (PASE) questionnaires at annual intervals over four years. Magnetic resonance imaging‐based cartilage thickness change in the medial femorotibial compartment (MFTC) over four years was the main outcome. The impact of PASE tertiles (low, moderate, high) on changes in MFTC cartilage thickness was estimated using a mixed effect model adjusted for baseline characteristics. Furthermore, straficiation by sex was performed for secondary analyses.ResultsStructural progression of MFTC cartilage loss of ‐0.20 mm (95% confidence interval: ‐0.22 to ‐0.17mm) was observed in the entire cohort, with no statistically significant difference between PA levels after adjustment for baseline characteristics. A sex‐by‐physical activity interaction was observed in the adjusted analysis (p=0.02). Stratification by sex showed that women with low PA had a statistically greater cartilage loss than women with moderate PA level (adjusted between group difference ‐0.09 mm [‐0.16 to ‐0.02 mm]), whereas no significant differences were observed in men.ConclusionWhile physical activity was not associated with cartilage thickness loss in the whole cohort, this relationship significantly differed between sexes. In women, but not in men, moderate PA may slow down structural disease progression compared to low PA levels. For both men and women, high PA does not appear to be more detrimental than lower PA levels for cartilage thickness loss.

AB - ObjectiveTo examine the impact of physical activity (PA) on cartilage thickness loss in knee osteoarthritis (KOA).Methods689 participants with radiographic KOA (Kellgren/Lawrence grade ≥2) at baseline, from the Osteoarthritis Initiative completed the Physical Activity Scale for the Elderly (PASE) questionnaires at annual intervals over four years. Magnetic resonance imaging‐based cartilage thickness change in the medial femorotibial compartment (MFTC) over four years was the main outcome. The impact of PASE tertiles (low, moderate, high) on changes in MFTC cartilage thickness was estimated using a mixed effect model adjusted for baseline characteristics. Furthermore, straficiation by sex was performed for secondary analyses.ResultsStructural progression of MFTC cartilage loss of ‐0.20 mm (95% confidence interval: ‐0.22 to ‐0.17mm) was observed in the entire cohort, with no statistically significant difference between PA levels after adjustment for baseline characteristics. A sex‐by‐physical activity interaction was observed in the adjusted analysis (p=0.02). Stratification by sex showed that women with low PA had a statistically greater cartilage loss than women with moderate PA level (adjusted between group difference ‐0.09 mm [‐0.16 to ‐0.02 mm]), whereas no significant differences were observed in men.ConclusionWhile physical activity was not associated with cartilage thickness loss in the whole cohort, this relationship significantly differed between sexes. In women, but not in men, moderate PA may slow down structural disease progression compared to low PA levels. For both men and women, high PA does not appear to be more detrimental than lower PA levels for cartilage thickness loss.

KW - physical activity

KW - cartilage

KW - load

KW - thickness

KW - osteoarthritis

KW - PROGRESSION DATA

KW - T2 MEASUREMENTS

KW - RISK

KW - FEMOROTIBIAL CARTILAGE

KW - ASYMPTOMATIC SUBJECTS

KW - ELDERLY PASE

KW - THICKNESS CHANGE

KW - RELAXATION-TIMES

KW - ACTIVITY SCALE

KW - ASSOCIATION

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UR - http://www.mendeley.com/research/moderate-physical-activity-prevention-cartilage-loss-people-knee-osteoarthritis-data-osteoarthritis

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DO - 10.1002/acr.23791

M3 - Article

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VL - 71

SP - 218

EP - 226

JO - Arthritis Care & Research

JF - Arthritis Care & Research

SN - 0893-7524

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ER -

Moderate physical activity may prevent cartilage loss in women with knee osteoarthritis: data from the Osteoarthritis Initiative

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Keywords

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