Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream

Anthony Ormerod, Marion White, S A Shah, N Benjamin

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A double-blind, group-sequential clinical trial of acidified nitrite was performed to demonstrate the efficacy of this nitric oxide donor in treating molluscum contagiosum. Subjects received either 5% sodium nitrite co-applied with 5% salicylic acid under occlusion, or identical cream with 5% salicylic acid, omitting sodium nitrite. Active and control treatment groups were well matched for the number and duration of lesions and made a similar number of applications. We found a 75% cure rate in the active treatment group and 21% cure with control treatment (P = 0.01). The mean time to cure was 1.83 months. Staining of the skin and irritation were frequent side-effects but did not prevent successful treatment.
Original languageEnglish
Pages (from-to)1051-1053
Number of pages3
JournalBritish Journal of Dermatology
Issue number6
Publication statusPublished - 1 Dec 1999



  • Administration, Cutaneous
  • Antiviral Agents
  • Child
  • Child, Preschool
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Infant
  • Male
  • Molluscum Contagiosum
  • Nitric Oxide Donors
  • Salicylic Acid
  • Sodium Nitrite
  • Treatment Outcome
  • Acidified nitrite
  • Antiviral
  • Molluscum
  • Contagiosum
  • Nitric oxide

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