Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream

Anthony Ormerod, Marion White, S A Shah, N Benjamin

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

A double-blind, group-sequential clinical trial of acidified nitrite was performed to demonstrate the efficacy of this nitric oxide donor in treating molluscum contagiosum. Subjects received either 5% sodium nitrite co-applied with 5% salicylic acid under occlusion, or identical cream with 5% salicylic acid, omitting sodium nitrite. Active and control treatment groups were well matched for the number and duration of lesions and made a similar number of applications. We found a 75% cure rate in the active treatment group and 21% cure with control treatment (P = 0.01). The mean time to cure was 1.83 months. Staining of the skin and irritation were frequent side-effects but did not prevent successful treatment.
Original languageEnglish
Pages (from-to)1051-1053
Number of pages3
JournalBritish Journal of Dermatology
Volume141
Issue number6
DOIs
Publication statusPublished - 1 Dec 1999

Fingerprint

Molluscum Contagiosum
Sodium Nitrite
Salicylic Acid
Nitrites
Nitric Oxide
Nitric Oxide Donors
Clinical Trials
Staining and Labeling
Control Groups
Skin

Keywords

  • Administration, Cutaneous
  • Antiviral Agents
  • Child
  • Child, Preschool
  • Double-Blind Method
  • Drug Combinations
  • Female
  • Humans
  • Infant
  • Male
  • Molluscum Contagiosum
  • Nitric Oxide Donors
  • Salicylic Acid
  • Sodium Nitrite
  • Treatment Outcome
  • Acidified nitrite
  • Antiviral
  • Molluscum
  • Contagiosum
  • Nitric oxide

Cite this

Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream. / Ormerod, Anthony; White, Marion; Shah, S A; Benjamin, N.

In: British Journal of Dermatology, Vol. 141, No. 6, 01.12.1999, p. 1051-1053.

Research output: Contribution to journalArticle

Ormerod, Anthony ; White, Marion ; Shah, S A ; Benjamin, N. / Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream. In: British Journal of Dermatology. 1999 ; Vol. 141, No. 6. pp. 1051-1053.
@article{c8c06235cd7d4ea2bd423bd3a573c9a9,
title = "Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream",
abstract = "A double-blind, group-sequential clinical trial of acidified nitrite was performed to demonstrate the efficacy of this nitric oxide donor in treating molluscum contagiosum. Subjects received either 5{\%} sodium nitrite co-applied with 5{\%} salicylic acid under occlusion, or identical cream with 5{\%} salicylic acid, omitting sodium nitrite. Active and control treatment groups were well matched for the number and duration of lesions and made a similar number of applications. We found a 75{\%} cure rate in the active treatment group and 21{\%} cure with control treatment (P = 0.01). The mean time to cure was 1.83 months. Staining of the skin and irritation were frequent side-effects but did not prevent successful treatment.",
keywords = "Administration, Cutaneous, Antiviral Agents, Child, Child, Preschool, Double-Blind Method, Drug Combinations, Female, Humans, Infant, Male, Molluscum Contagiosum, Nitric Oxide Donors, Salicylic Acid, Sodium Nitrite, Treatment Outcome, Acidified nitrite, Antiviral, Molluscum, Contagiosum, Nitric oxide",
author = "Anthony Ormerod and Marion White and Shah, {S A} and N Benjamin",
year = "1999",
month = "12",
day = "1",
doi = "10.1046/j.1365-2133.1999.03204.x",
language = "English",
volume = "141",
pages = "1051--1053",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "Wiley",
number = "6",

}

TY - JOUR

T1 - Molluscum contagiosum effectively treated with a topical acidified nitrite, nitric oxide liberating cream

AU - Ormerod, Anthony

AU - White, Marion

AU - Shah, S A

AU - Benjamin, N

PY - 1999/12/1

Y1 - 1999/12/1

N2 - A double-blind, group-sequential clinical trial of acidified nitrite was performed to demonstrate the efficacy of this nitric oxide donor in treating molluscum contagiosum. Subjects received either 5% sodium nitrite co-applied with 5% salicylic acid under occlusion, or identical cream with 5% salicylic acid, omitting sodium nitrite. Active and control treatment groups were well matched for the number and duration of lesions and made a similar number of applications. We found a 75% cure rate in the active treatment group and 21% cure with control treatment (P = 0.01). The mean time to cure was 1.83 months. Staining of the skin and irritation were frequent side-effects but did not prevent successful treatment.

AB - A double-blind, group-sequential clinical trial of acidified nitrite was performed to demonstrate the efficacy of this nitric oxide donor in treating molluscum contagiosum. Subjects received either 5% sodium nitrite co-applied with 5% salicylic acid under occlusion, or identical cream with 5% salicylic acid, omitting sodium nitrite. Active and control treatment groups were well matched for the number and duration of lesions and made a similar number of applications. We found a 75% cure rate in the active treatment group and 21% cure with control treatment (P = 0.01). The mean time to cure was 1.83 months. Staining of the skin and irritation were frequent side-effects but did not prevent successful treatment.

KW - Administration, Cutaneous

KW - Antiviral Agents

KW - Child

KW - Child, Preschool

KW - Double-Blind Method

KW - Drug Combinations

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Molluscum Contagiosum

KW - Nitric Oxide Donors

KW - Salicylic Acid

KW - Sodium Nitrite

KW - Treatment Outcome

KW - Acidified nitrite

KW - Antiviral

KW - Molluscum

KW - Contagiosum

KW - Nitric oxide

U2 - 10.1046/j.1365-2133.1999.03204.x

DO - 10.1046/j.1365-2133.1999.03204.x

M3 - Article

C2 - 10606851

VL - 141

SP - 1051

EP - 1053

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 6

ER -