Multifunctional redox catalysts as selective enhancers of oxidative stress

Fiona H. Fry, Andrea L. Holme, Niroshini M. Giles, Gregory I. Giles, Catriona Collins, Kim Holt, Sandra Pariagh, Thomas Gelbrich, Michael B. Hursthouse, Nick J. Gutowski, Claus Jacob*

*Corresponding author for this work

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.

Original languageEnglish
Pages (from-to)2579-2587
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume3
Issue number14
Early online date9 Jun 2005
DOIs
Publication statusPublished - 21 Jul 2005

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