Myocardial contractile inefficiency and dyssynchrony in heart failure with preserved ejection fraction and narrow QRS complex

Thanh T. Phan, Khalid Abozguia, Ganesh Nallur Shivu, Ibrar Ahmed, Kiran Patel, Francisco Leyva, Michael Frenneaux

Research output: Contribution to journalArticle

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Abstract

Background: Using speckle-tracking imaging (STI), the aims of this study were to assess dyssynchrony and quantify the myocardial energy wasted by contractility in delayed segments by determining the longitudinal strain delay index (LSDi) in patients with heart failure with preserved ejection fraction (HFpEF).

Method: Thirty-eight patients with HFpEF and 33 matched controls were recruited. All subjects underwent clinical examinations, 12-lead electrocardiography, pulmonary function tests, echocardiography, and metabolic exercise tests. LSDi was determined, the magnitude of which is a measure of the amount of wasted energy. Global and segmental systolic and diastolic dyssynchrony was assessed by STI.

Results: LSDi was significantly higher in patients with HFpEF than controls (-14.36 +/- 8.24% vs -10.73 +/- 5.62%, P < .05). Patients with HFpEF exhibited left ventricular (LV) systolic and diastolic dyssynchrony, with the LV anterior wall displaying the most delayed motion.

Conclusion: Patients with HFpEF exhibited increased myocardial contractile inefficiency. They also exhibited LV systolic and diastolic dyssynchrony, with the LV anterior wall displaying the most delayed motion.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalJournal of the American Society of Echocardiography
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2010

Keywords

  • dyssynchrony
  • contractile inefficiency
  • heart failure with preserved ejection fraction
  • speckle-tracking imaging
  • cardiac resynchronization therapy
  • speckle tracking echocardiography
  • ventricular systolic function
  • doppler-echocardiography
  • diastolic dysfunction
  • longitudinal strain
  • filling pressures
  • validation
  • duration
  • relaxation

Cite this

Myocardial contractile inefficiency and dyssynchrony in heart failure with preserved ejection fraction and narrow QRS complex. / Phan, Thanh T.; Abozguia, Khalid; Shivu, Ganesh Nallur; Ahmed, Ibrar; Patel, Kiran; Leyva, Francisco; Frenneaux, Michael.

In: Journal of the American Society of Echocardiography, Vol. 23, No. 2, 02.2010, p. 201-206.

Research output: Contribution to journalArticle

Phan, Thanh T. ; Abozguia, Khalid ; Shivu, Ganesh Nallur ; Ahmed, Ibrar ; Patel, Kiran ; Leyva, Francisco ; Frenneaux, Michael. / Myocardial contractile inefficiency and dyssynchrony in heart failure with preserved ejection fraction and narrow QRS complex. In: Journal of the American Society of Echocardiography. 2010 ; Vol. 23, No. 2. pp. 201-206.
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abstract = "Background: Using speckle-tracking imaging (STI), the aims of this study were to assess dyssynchrony and quantify the myocardial energy wasted by contractility in delayed segments by determining the longitudinal strain delay index (LSDi) in patients with heart failure with preserved ejection fraction (HFpEF).Method: Thirty-eight patients with HFpEF and 33 matched controls were recruited. All subjects underwent clinical examinations, 12-lead electrocardiography, pulmonary function tests, echocardiography, and metabolic exercise tests. LSDi was determined, the magnitude of which is a measure of the amount of wasted energy. Global and segmental systolic and diastolic dyssynchrony was assessed by STI.Results: LSDi was significantly higher in patients with HFpEF than controls (-14.36 +/- 8.24{\%} vs -10.73 +/- 5.62{\%}, P < .05). Patients with HFpEF exhibited left ventricular (LV) systolic and diastolic dyssynchrony, with the LV anterior wall displaying the most delayed motion.Conclusion: Patients with HFpEF exhibited increased myocardial contractile inefficiency. They also exhibited LV systolic and diastolic dyssynchrony, with the LV anterior wall displaying the most delayed motion.",
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