Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS

Anvesha Singh*, Michael Jerosch-Herold, John P. Greenwood, Colin Berry, Dana K. Dawson, Chim C. Lang, Damian J. Kelly, David Sprigings, Jeffrey P. Khoo, Kai Hogrefe, Richard P. Steeds, Vijay Anand Dhakshinamurthy, Gerry P. McCann

*Corresponding author for this work

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Abstract

The timing of surgery in asymptomatic patients with aortic stenosis (AS) is controversial. Adverse LV remodeling is related to prognosis in AS. Cardiovascular magnetic resonance (CMR) can identify diffuse and focal myocardial fibrosis, by T1 mapping and late gadolinium enhancement (LGE) respectively, as well as myocardial perfusion reserve (MPR), which is inversely related to symptoms and an independent predictor of exercise capacity in severe AS. The aim of this study was to determine whether MPR and other CMR markers of LV remodeling are of prognostic value in asymptomatic AS.
Original languageEnglish
Article numberO36
Number of pages2
JournalJournal of Cardiovascular Magnetic Resonance
Volume18
Issue numberSupplement 1
DOIs
Publication statusPublished - 27 Jan 2016
Event19th Annual SCMR Scientific Sessions - Los Angeles, United States
Duration: 27 Jan 201630 Jan 2016

Keywords

  • Cardiovascular Magnetic Resonance
  • Aortic Stenosis
  • Asymptomatic Patient
  • Late Gadolinium Enhancement
  • Aortic Valve Replacement

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    Singh, A., Jerosch-Herold, M., Greenwood, J. P., Berry, C., Dawson, D. K., Lang, C. C., Kelly, D. J., Sprigings, D., Khoo, J. P., Hogrefe, K., Steeds, R. P., Dhakshinamurthy, V. A., & McCann, G. P. (2016). Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS. Journal of Cardiovascular Magnetic Resonance, 18(Supplement 1), [O36]. https://doi.org/10.1186/1532-429X-18-S1-O36