Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS

Anvesha Singh; Michael Jerosch-Herold; John P. Greenwood; Colin Berry; Dana K. Dawson; Chim C. Lang; Damian J. Kelly; David Sprigings; Jeffrey P. Khoo; Kai Hogrefe; Richard P. Steeds; Vijay Anand Dhakshinamurthy; Gerry P. McCann

doi:10.1186/1532-429X-18-S1-O36

Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS

Anvesha Singh^*, Michael Jerosch-Herold, John P. Greenwood, Colin Berry, Dana K. Dawson, Chim C. Lang, Damian J. Kelly, David Sprigings, Jeffrey P. Khoo, Kai Hogrefe, Richard P. Steeds, Vijay Anand Dhakshinamurthy, Gerry P. McCann

^*Corresponding author for this work

Applied Medicine

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Abstract

The timing of surgery in asymptomatic patients with aortic stenosis (AS) is controversial. Adverse LV remodeling is related to prognosis in AS. Cardiovascular magnetic resonance (CMR) can identify diffuse and focal myocardial fibrosis, by T1 mapping and late gadolinium enhancement (LGE) respectively, as well as myocardial perfusion reserve (MPR), which is inversely related to symptoms and an independent predictor of exercise capacity in severe AS. The aim of this study was to determine whether MPR and other CMR markers of LV remodeling are of prognostic value in asymptomatic AS.

Original language	English
Article number	O36
Number of pages	2
Journal	Journal of Cardiovascular Magnetic Resonance
Volume	18
Issue number	Supplement 1
DOIs	https://doi.org/10.1186/1532-429X-18-S1-O36
Publication status	Published - 27 Jan 2016
Event	19th Annual SCMR Scientific Sessions - Los Angeles, United States Duration: 27 Jan 2016 → 30 Jan 2016

Keywords

Cardiovascular Magnetic Resonance
Aortic Stenosis
Asymptomatic Patient
Late Gadolinium Enhancement
Aortic Valve Replacement

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10.1186/1532-429X-18-S1-O36Licence: CC BY

Singh_et_al_JoCMR_MyocardialPerfusion_VoR
© 2016 Singh et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http:// creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/ zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 268 KBLicence: CC BY

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Singh, A., Jerosch-Herold, M., Greenwood, J. P., Berry, C., Dawson, D. K., Lang, C. C., Kelly, D. J., Sprigings, D., Khoo, J. P., Hogrefe, K., Steeds, R. P., Dhakshinamurthy, V. A., & McCann, G. P. (2016). Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS. Journal of Cardiovascular Magnetic Resonance, 18(Supplement 1), Article O36. https://doi.org/10.1186/1532-429X-18-S1-O36

Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS. / Singh, Anvesha; Jerosch-Herold, Michael; Greenwood, John P. et al.
In: Journal of Cardiovascular Magnetic Resonance, Vol. 18, No. Supplement 1, O36, 27.01.2016.

Research output: Contribution to journal › Article › peer-review

Singh, A, Jerosch-Herold, M, Greenwood, JP, Berry, C, Dawson, DK, Lang, CC, Kelly, DJ, Sprigings, D, Khoo, JP, Hogrefe, K, Steeds, RP, Dhakshinamurthy, VA & McCann, GP 2016, 'Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS', Journal of Cardiovascular Magnetic Resonance, vol. 18, no. Supplement 1, O36. https://doi.org/10.1186/1532-429X-18-S1-O36

Singh A, Jerosch-Herold M, Greenwood JP, Berry C, Dawson DK, Lang CC et al. Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS. Journal of Cardiovascular Magnetic Resonance. 2016 Jan 27;18(Supplement 1):O36. doi: 10.1186/1532-429X-18-S1-O36

Singh, Anvesha ; Jerosch-Herold, Michael ; Greenwood, John P. et al. / Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis : the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS. In: Journal of Cardiovascular Magnetic Resonance. 2016 ; Vol. 18, No. Supplement 1.

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abstract = "The timing of surgery in asymptomatic patients with aortic stenosis (AS) is controversial. Adverse LV remodeling is related to prognosis in AS. Cardiovascular magnetic resonance (CMR) can identify diffuse and focal myocardial fibrosis, by T1 mapping and late gadolinium enhancement (LGE) respectively, as well as myocardial perfusion reserve (MPR), which is inversely related to symptoms and an independent predictor of exercise capacity in severe AS. The aim of this study was to determine whether MPR and other CMR markers of LV remodeling are of prognostic value in asymptomatic AS.",

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AU - Berry, Colin

AU - Dawson, Dana K.

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AU - Kelly, Damian J.

AU - Sprigings, David

AU - Khoo, Jeffrey P.

AU - Hogrefe, Kai

AU - Steeds, Richard P.

AU - Dhakshinamurthy, Vijay Anand

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AB - The timing of surgery in asymptomatic patients with aortic stenosis (AS) is controversial. Adverse LV remodeling is related to prognosis in AS. Cardiovascular magnetic resonance (CMR) can identify diffuse and focal myocardial fibrosis, by T1 mapping and late gadolinium enhancement (LGE) respectively, as well as myocardial perfusion reserve (MPR), which is inversely related to symptoms and an independent predictor of exercise capacity in severe AS. The aim of this study was to determine whether MPR and other CMR markers of LV remodeling are of prognostic value in asymptomatic AS.

KW - Cardiovascular Magnetic Resonance

KW - Aortic Stenosis

KW - Asymptomatic Patient

KW - Late Gadolinium Enhancement

KW - Aortic Valve Replacement

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Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS

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Keywords

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