Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis

the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS

Anvesha Singh*, Michael Jerosch-Herold, John P. Greenwood, Colin Berry, Dana K. Dawson, Chim C. Lang, Damian J. Kelly, David Sprigings, Jeffrey P. Khoo, Kai Hogrefe, Richard P. Steeds, Vijay Anand Dhakshinamurthy, Gerry P. McCann

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The timing of surgery in asymptomatic patients with aortic stenosis (AS) is controversial. Adverse LV remodeling is related to prognosis in AS. Cardiovascular magnetic resonance (CMR) can identify diffuse and focal myocardial fibrosis, by T1 mapping and late gadolinium enhancement (LGE) respectively, as well as myocardial perfusion reserve (MPR), which is inversely related to symptoms and an independent predictor of exercise capacity in severe AS. The aim of this study was to determine whether MPR and other CMR markers of LV remodeling are of prognostic value in asymptomatic AS.
Original languageEnglish
Article numberO36
Number of pages2
JournalJournal of Cardiovascular Magnetic Resonance
Volume18
Issue numberSupplement 1
DOIs
Publication statusPublished - 27 Jan 2016
Event19th Annual SCMR Scientific Sessions - Los Angeles, United States
Duration: 27 Jan 201630 Jan 2016

Fingerprint

Aortic Valve Stenosis
Fibrosis
Perfusion
Magnetic Resonance Spectroscopy
Gadolinium
Exercise

Keywords

  • Cardiovascular Magnetic Resonance
  • Aortic Stenosis
  • Asymptomatic Patient
  • Late Gadolinium Enhancement
  • Aortic Valve Replacement

Cite this

Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis : the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS. / Singh, Anvesha; Jerosch-Herold, Michael; Greenwood, John P.; Berry, Colin; Dawson, Dana K.; Lang, Chim C.; Kelly, Damian J.; Sprigings, David; Khoo, Jeffrey P.; Hogrefe, Kai; Steeds, Richard P.; Dhakshinamurthy, Vijay Anand; McCann, Gerry P.

In: Journal of Cardiovascular Magnetic Resonance, Vol. 18, No. Supplement 1, O36, 27.01.2016.

Research output: Contribution to journalArticle

Singh, Anvesha ; Jerosch-Herold, Michael ; Greenwood, John P. ; Berry, Colin ; Dawson, Dana K. ; Lang, Chim C. ; Kelly, Damian J. ; Sprigings, David ; Khoo, Jeffrey P. ; Hogrefe, Kai ; Steeds, Richard P. ; Dhakshinamurthy, Vijay Anand ; McCann, Gerry P. / Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis : the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS. In: Journal of Cardiovascular Magnetic Resonance. 2016 ; Vol. 18, No. Supplement 1.
@article{2f700353517c4c7dad74621cd59e4d3d,
title = "Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS",
abstract = "The timing of surgery in asymptomatic patients with aortic stenosis (AS) is controversial. Adverse LV remodeling is related to prognosis in AS. Cardiovascular magnetic resonance (CMR) can identify diffuse and focal myocardial fibrosis, by T1 mapping and late gadolinium enhancement (LGE) respectively, as well as myocardial perfusion reserve (MPR), which is inversely related to symptoms and an independent predictor of exercise capacity in severe AS. The aim of this study was to determine whether MPR and other CMR markers of LV remodeling are of prognostic value in asymptomatic AS.",
keywords = "Cardiovascular Magnetic Resonance, Aortic Stenosis, Asymptomatic Patient, Late Gadolinium Enhancement, Aortic Valve Replacement",
author = "Anvesha Singh and Michael Jerosch-Herold and Greenwood, {John P.} and Colin Berry and Dawson, {Dana K.} and Lang, {Chim C.} and Kelly, {Damian J.} and David Sprigings and Khoo, {Jeffrey P.} and Kai Hogrefe and Steeds, {Richard P.} and Dhakshinamurthy, {Vijay Anand} and McCann, {Gerry P.}",
year = "2016",
month = "1",
day = "27",
doi = "10.1186/1532-429X-18-S1-O36",
language = "English",
volume = "18",
journal = "Journal of Cardiovascular Magnetic Resonance",
issn = "1097-6647",
publisher = "BioMed Central",
number = "Supplement 1",

}

TY - JOUR

T1 - Myocardial Perfusion Reserve but not fibrosis predicts outcomes in initially asymptomatic patients with moderate to severe aortic stenosis

T2 - the PRognostic Importance of MIcrovascular Dysfunction in AS study- PRIMID AS

AU - Singh, Anvesha

AU - Jerosch-Herold, Michael

AU - Greenwood, John P.

AU - Berry, Colin

AU - Dawson, Dana K.

AU - Lang, Chim C.

AU - Kelly, Damian J.

AU - Sprigings, David

AU - Khoo, Jeffrey P.

AU - Hogrefe, Kai

AU - Steeds, Richard P.

AU - Dhakshinamurthy, Vijay Anand

AU - McCann, Gerry P.

PY - 2016/1/27

Y1 - 2016/1/27

N2 - The timing of surgery in asymptomatic patients with aortic stenosis (AS) is controversial. Adverse LV remodeling is related to prognosis in AS. Cardiovascular magnetic resonance (CMR) can identify diffuse and focal myocardial fibrosis, by T1 mapping and late gadolinium enhancement (LGE) respectively, as well as myocardial perfusion reserve (MPR), which is inversely related to symptoms and an independent predictor of exercise capacity in severe AS. The aim of this study was to determine whether MPR and other CMR markers of LV remodeling are of prognostic value in asymptomatic AS.

AB - The timing of surgery in asymptomatic patients with aortic stenosis (AS) is controversial. Adverse LV remodeling is related to prognosis in AS. Cardiovascular magnetic resonance (CMR) can identify diffuse and focal myocardial fibrosis, by T1 mapping and late gadolinium enhancement (LGE) respectively, as well as myocardial perfusion reserve (MPR), which is inversely related to symptoms and an independent predictor of exercise capacity in severe AS. The aim of this study was to determine whether MPR and other CMR markers of LV remodeling are of prognostic value in asymptomatic AS.

KW - Cardiovascular Magnetic Resonance

KW - Aortic Stenosis

KW - Asymptomatic Patient

KW - Late Gadolinium Enhancement

KW - Aortic Valve Replacement

UR - http://europepmc.org/abstract/PMC/PMC5032407

U2 - 10.1186/1532-429X-18-S1-O36

DO - 10.1186/1532-429X-18-S1-O36

M3 - Article

VL - 18

JO - Journal of Cardiovascular Magnetic Resonance

JF - Journal of Cardiovascular Magnetic Resonance

SN - 1097-6647

IS - Supplement 1

M1 - O36

ER -