Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection

Donna Margaret MacCallum; Frank Christopher Odds

doi:10.1128/AAC.48.12.4911-4914.2004

Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection

Donna Margaret MacCallum, Frank Christopher Odds

Medical Sciences

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Groups of mice infected intravenously with Candida albicans were treated intraperitoneally with amphotericin B, caspofungin, or fluconazole, starting at intervals before and after challenge. Survival was longest and tissue burdens were most reduced with early treatment, and survival times fell proportionately as treatment was delayed, reinforcing clinical recommendations for the earliest possible initiation of antifungal therapy.

Original language	English
Pages (from-to)	4911-4914
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	48
Issue number	12
DOIs	https://doi.org/10.1128/AAC.48.12.4911-4914.2004
Publication status	Published - 1 Dec 2004

Keywords

Amphotericin B
Animals
Antifungal Agents
Brain
Candidiasis
Colony-Forming Units Assay
Echinocandins
Female
Fluconazole
Injections, Intraperitoneal
Mice
Mice, Inbred BALB C
Peptides, Cyclic
Survival Analysis
Treatment Outcome

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10.1128/AAC.48.12.4911-4914.2004

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title = "Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection",

abstract = "Groups of mice infected intravenously with Candida albicans were treated intraperitoneally with amphotericin B, caspofungin, or fluconazole, starting at intervals before and after challenge. Survival was longest and tissue burdens were most reduced with early treatment, and survival times fell proportionately as treatment was delayed, reinforcing clinical recommendations for the earliest possible initiation of antifungal therapy.",

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author = "MacCallum, {Donna Margaret} and Odds, {Frank Christopher}",

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T1 - Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection

AU - MacCallum, Donna Margaret

AU - Odds, Frank Christopher

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AB - Groups of mice infected intravenously with Candida albicans were treated intraperitoneally with amphotericin B, caspofungin, or fluconazole, starting at intervals before and after challenge. Survival was longest and tissue burdens were most reduced with early treatment, and survival times fell proportionately as treatment was delayed, reinforcing clinical recommendations for the earliest possible initiation of antifungal therapy.

KW - Amphotericin B

KW - Animals

KW - Antifungal Agents

KW - Brain

KW - Candidiasis

KW - Colony-Forming Units Assay

KW - Echinocandins

KW - Female

KW - Fluconazole

KW - Injections, Intraperitoneal

KW - Mice

KW - Mice, Inbred BALB C

KW - Peptides, Cyclic

KW - Survival Analysis

KW - Treatment Outcome

U2 - 10.1128/AAC.48.12.4911-4914.2004

DO - 10.1128/AAC.48.12.4911-4914.2004

M3 - Article

C2 - 15561880

SN - 0066-4804

VL - 48

SP - 4911

EP - 4914

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 12

ER -

Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection

Abstract

Keywords

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