Need for early antifungal treatment confirmed in experimental disseminated Candida albicans infection

Donna Margaret MacCallum, Frank Christopher Odds

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Groups of mice infected intravenously with Candida albicans were treated intraperitoneally with amphotericin B, caspofungin, or fluconazole, starting at intervals before and after challenge. Survival was longest and tissue burdens were most reduced with early treatment, and survival times fell proportionately as treatment was delayed, reinforcing clinical recommendations for the earliest possible initiation of antifungal therapy.
Original languageEnglish
Pages (from-to)4911-4914
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume48
Issue number12
DOIs
Publication statusPublished - 1 Dec 2004

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Keywords

  • Amphotericin B
  • Animals
  • Antifungal Agents
  • Brain
  • Candidiasis
  • Colony-Forming Units Assay
  • Echinocandins
  • Female
  • Fluconazole
  • Injections, Intraperitoneal
  • Mice
  • Mice, Inbred BALB C
  • Peptides, Cyclic
  • Survival Analysis
  • Treatment Outcome

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