Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo

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Abstract

Biological roles for naturally occurring, extracellular physiological electric fields have been proposed over the past century. However, in the molecular era, many biologists presume that electric fields have little physiological relevance because there has been no unequivocal demonstration of their importance at the single-cell level in vivo. We have used an in vivo rat corneal model, which generates its own endogenous electric field and show that nerve sprouting, the direction of nerve growth and the rate of epithelial wound healing are controlled coordinately by the wound-induced electric field.

Original languageEnglish
Pages (from-to)4681-4690
Number of pages9
JournalJournal of Cell Science
Volume117
Issue number20
DOIs
Publication statusPublished - Sep 2004

Keywords

  • nerve regeneration
  • wound healing
  • cornea
  • electric field
  • GROWTH CONE GUIDANCE
  • NA+-K+ PUMP
  • CORNEAL EPITHELIUM
  • CHLORIDE TRANSPORT
  • FROG CORNEA
  • CELL-MIGRATION
  • ION-TRANSPORT
  • CYCLIC-AMP
  • RABBIT
  • ORIENTATION

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