Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives

Iain Robert Greig (Inventor), Peter Teismann (Inventor), Uwe-Karsten Hanisch (Inventor), Wolfgang Bruck (Inventor)

Research output: Patent

Abstract

Use of a compound of the following formula in the treatment or prophylaxis of neurodegeneration: wherein R1, R2, R3, R4 and R5 are each selected from hydrogen and a substituent; W is selected from hydrogen and saturated C1-6 alkyl; Q is selected from CN and a carbonyl-linked substituent. These compounds are useful as neuroprotectives, for example, in the treatment or prophylaxis of neurodegeneration, a neurodegenerative disease or disorder, etc. In further aspects, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, as neuroprotectives, for example, in the treatment or prophylaxis of neurodegeneration, for example, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), multiple sclerosis (MS), Huntington's disease (HD), etc.
Original languageEnglish
Patent numberGB2458259
IPCGB2458259
Publication statusPublished - 16 Sep 2009

Fingerprint

Derivatives
Hydrogen
Neurodegenerative diseases
Chemical analysis
Pharmaceutical Preparations

Cite this

Greig, I. R., Teismann, P., Hanisch, U-K., & Bruck, W. (2009). IPC No. GB2458259. Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives. (Patent No. GB2458259).

Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives. / Greig, Iain Robert (Inventor); Teismann, Peter (Inventor); Hanisch, Uwe-Karsten (Inventor); Bruck, Wolfgang (Inventor).

IPC No.: GB2458259. Patent No.: GB2458259.

Research output: Patent

Greig, IR, Teismann, P, Hanisch, U-K & Bruck, W 2009, Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives, Patent No. GB2458259, IPC No. GB2458259.
Greig IR, Teismann P, Hanisch U-K, Bruck W, inventors. Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives. GB2458259. 2009 Sep 16.
Greig, Iain Robert (Inventor) ; Teismann, Peter (Inventor) ; Hanisch, Uwe-Karsten (Inventor) ; Bruck, Wolfgang (Inventor). / Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives. IPC No.: GB2458259. Patent No.: GB2458259.
@misc{242a2314a7e94766add4831abf87f212,
title = "Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives",
abstract = "Use of a compound of the following formula in the treatment or prophylaxis of neurodegeneration: wherein R1, R2, R3, R4 and R5 are each selected from hydrogen and a substituent; W is selected from hydrogen and saturated C1-6 alkyl; Q is selected from CN and a carbonyl-linked substituent. These compounds are useful as neuroprotectives, for example, in the treatment or prophylaxis of neurodegeneration, a neurodegenerative disease or disorder, etc. In further aspects, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, as neuroprotectives, for example, in the treatment or prophylaxis of neurodegeneration, for example, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), multiple sclerosis (MS), Huntington's disease (HD), etc.",
author = "Greig, {Iain Robert} and Peter Teismann and Uwe-Karsten Hanisch and Wolfgang Bruck",
year = "2009",
month = "9",
day = "16",
language = "English",
type = "Patent",
note = "GB2458259; GB2458259",

}

TY - PAT

T1 - Neuroprotective 3-phenylacrylonitrile (3-PAN) derivatives

AU - Greig, Iain Robert

AU - Teismann, Peter

AU - Hanisch, Uwe-Karsten

AU - Bruck, Wolfgang

PY - 2009/9/16

Y1 - 2009/9/16

N2 - Use of a compound of the following formula in the treatment or prophylaxis of neurodegeneration: wherein R1, R2, R3, R4 and R5 are each selected from hydrogen and a substituent; W is selected from hydrogen and saturated C1-6 alkyl; Q is selected from CN and a carbonyl-linked substituent. These compounds are useful as neuroprotectives, for example, in the treatment or prophylaxis of neurodegeneration, a neurodegenerative disease or disorder, etc. In further aspects, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, as neuroprotectives, for example, in the treatment or prophylaxis of neurodegeneration, for example, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), multiple sclerosis (MS), Huntington's disease (HD), etc.

AB - Use of a compound of the following formula in the treatment or prophylaxis of neurodegeneration: wherein R1, R2, R3, R4 and R5 are each selected from hydrogen and a substituent; W is selected from hydrogen and saturated C1-6 alkyl; Q is selected from CN and a carbonyl-linked substituent. These compounds are useful as neuroprotectives, for example, in the treatment or prophylaxis of neurodegeneration, a neurodegenerative disease or disorder, etc. In further aspects, pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, for example, as neuroprotectives, for example, in the treatment or prophylaxis of neurodegeneration, for example, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), multiple sclerosis (MS), Huntington's disease (HD), etc.

M3 - Patent

M1 - GB2458259

ER -