Nitrosative and oxidative stress responses in fungal pathogenicity

Alistair J P Brown; Ken Haynes; Janet Quinn

doi:10.1016/j.mib.2009.06.007

Nitrosative and oxidative stress responses in fungal pathogenicity

Alistair J P Brown, Ken Haynes, Janet Quinn

Medical Sciences

Research output: Contribution to journal › Article › peer-review

138 Citations (Scopus)

Abstract

Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.

Original language	English
Pages (from-to)	384-391
Number of pages	8
Journal	Current Opinion in Microbiology
Volume	12
Issue number	4
Early online date	16 Jul 2009
DOIs	https://doi.org/10.1016/j.mib.2009.06.007
Publication status	Published - Aug 2009

Bibliographical note

A paid open access option is available for this journal.
Voluntary deposit by author of pre-print allowed on Institutions open scholarly website and pre-print servers
Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository
Deposit due to Funding Body, Institutional and Governmental mandate only allowed where separate agreement between repository and publisher exists
Set statement to accompany deposit
Published source must be acknowledged
Must link to journal home page or articles' DOI
Publisher's version/PDF cannot be used
Articles in some journals can be made Open Access on payment of additional charge
NIH Authors articles will be submitted to PubMed Central after <num>12</num> <period units="month">months</period>
Authors who are required to deposit in subject-based repositories may also use Sponsorship Option

Keywords

antifungal agents
fungi
host-pathogen interactions
humans
models, biological
nitroso compounds
oxidants
oxidative stress
stress, physiological

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10.1016/j.mib.2009.06.007

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title = "Nitrosative and oxidative stress responses in fungal pathogenicity",

abstract = "Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.",

keywords = "antifungal agents, fungi, host-pathogen interactions, humans, models, biological, nitroso compounds, oxidants, oxidative stress, stress, physiological",

author = "Brown, {Alistair J P} and Ken Haynes and Janet Quinn",

note = "A paid open access option is available for this journal. Voluntary deposit by author of pre-print allowed on Institutions open scholarly website and pre-print servers Voluntary deposit by author of authors post-print allowed on institutions open scholarly website including Institutional Repository Deposit due to Funding Body, Institutional and Governmental mandate only allowed where separate agreement between repository and publisher exists Set statement to accompany deposit Published source must be acknowledged Must link to journal home page or articles' DOI Publisher's version/PDF cannot be used Articles in some journals can be made Open Access on payment of additional charge NIH Authors articles will be submitted to PubMed Central after <num>12</num> <period units={"}month{"}>months</period> Authors who are required to deposit in subject-based repositories may also use Sponsorship Option",

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doi = "10.1016/j.mib.2009.06.007",

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AU - Haynes, Ken

AU - Quinn, Janet

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N2 - Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.

AB - Fungal pathogenicity has arisen in polyphyletic manner during evolution, yielding fungal pathogens with diverse infection strategies and with differing degrees of evolutionary adaptation to their human host. Not surprisingly, these fungal pathogens display differing degrees of resistance to the reactive oxygen and nitrogen species used by human cells to counteract infection. Furthermore, whilst evolutionarily conserved regulators, such as Hog1, are central to such stress responses in many fungal pathogens, species-specific differences in their roles and regulation abound. In contrast, there is a high degree of commonality in the cellular responses to reactive oxygen and nitrogen species evoked in evolutionarily divergent fungal pathogens.

KW - antifungal agents

KW - fungi

KW - host-pathogen interactions

KW - humans

KW - models, biological

KW - nitroso compounds

KW - oxidants

KW - oxidative stress

KW - stress, physiological

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DO - 10.1016/j.mib.2009.06.007

M3 - Article

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SN - 1879-0364

VL - 12

SP - 384

EP - 391

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

IS - 4

ER -

Nitrosative and oxidative stress responses in fungal pathogenicity

Abstract

Bibliographical note

Keywords

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