No evidence that CDKN1B (p27) polymorphisms modify breast cancer risk in BRCA1 and BRCA2 mutation carriers

Amanda B Spurdle, Andrew J Deans, David Duffy, David E Goldgar, Xiaoqing Chen, Jonathan Beesley, Douglas F Easton, Antonis C Antoniou, Susan Peock, Margaret Cook, Katherine L Nathanson, Susan M Domchek, Grant A MacArthur, Georgia Chenevix-Trench, Neva Haites, kConFaB

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Abstract

The p27(kip1) protein functions as an inhibitor of cyclin dependent kinase-2, and shows loss of expression in a large percentage of BRCA1 and BRCA2 breast cancer cases. We investigated the association between CDKN1B gene variants and breast cancer risk in 2359 female BRCA1 and BRCA2 mutation carriers from Australia, the UK, and the USA. Samples were genotyped for five single nucleotide polymorphisms, including coding variant rs2066827 (V109G). Cox regression provided no convincing evidence that any of the polymorphisms modified disease risk for BRCA1 or BRCA2 carriers, either alone or as a haplotype. Borderline associations were observed for homozygote carriers of the rs3759216 rare allele, but were opposite in effect for BRCA1 and BRCA2 carriers (adjusted hazard ratio (HR) 0.72 (95% CI = 0.53-0.99; P = 0.04 for BRCA1, HR 1.47 (95% CI = 0.99-2.18; P = 0.06 for BRCA2). The 95% confidence intervals for per allele risk estimates excluded a twofold risk, indicating that common CDKN1B polymorphisms do not markedly modify breast cancer risk among BRCA1 or BRCA2 carriers.
Original languageEnglish
Pages (from-to)307-313
Number of pages7
JournalBreast Cancer Research and Treatment
Volume115
Issue number2
Early online date10 Jun 2008
DOIs
Publication statusPublished - May 2009

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Keywords

  • breast neoplasms
  • female
  • genes, BRCA1
  • genes, BRCA2
  • genetic predisposition to disease
  • humans
  • intracellular signaling peptides and proteins
  • mutation
  • polymorphism, single nucleotide
  • risk factors
  • P27
  • BRCA1
  • BRCA2
  • modifier

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