Non-cytotoxic antibodies in chronic lymphocytic leukaemia

A M MacLeod, E J Minford, D J King, A A Dawson, N B Bennett, G R Catto

Research output: Contribution to journalArticle

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Abstract

Non-cytotoxic Fc receptor blocking antibodies against autologous B lymphocytes were sought in sera from patients with chronic lymphocytic leukaemia (CLL), using a rosette inhibition assay. They were found in 11 of 52 (21%) of patients with CLL, but were not associated with previous blood transfusion or pregnancy, suggesting that they were unlikely to have resulted from allogeneic stimulation. Fc receptor blockade was more commonly detected in sera from patients with stage B rather than stage A CLL (Binet classification), though this did not achieve significance beyond the 90% level, and it was noted in 62.5% of those with lymphocyte doubling times of less than one year, compared with 36.3% of those whose lymphocyte doubling time was more than one year. The results indicate that autologous Fc receptor blocking antibody activity occurs in sera from patients with CLL, is more likely to be generated by the tumour itself than by allogeneic stimulation, and is associated with increased tumour load. Such antibodies may permit tolerance of tumour by the host.
Original languageEnglish
Pages (from-to)766-70
Number of pages5
JournalJournal of Clinical Pathology
Volume40
Issue number7
Publication statusPublished - 1 Jul 1987

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B-Cell Chronic Lymphocytic Leukemia
Fc Receptors
Blocking Antibodies
Antibodies
Serum
Lymphocytes
Tumor Burden
Blood Transfusion
Neoplasms
B-Lymphocytes
Pregnancy

Keywords

  • Autoantibodies
  • B-Lymphocytes
  • Binding, Competitive
  • Blood Transfusion
  • Female
  • Humans
  • Leukemia, Lymphoid
  • Leukocyte Count
  • Male
  • Middle Aged
  • Mitosis
  • Neoplasm Staging
  • Receptors, Fc
  • Rosette Formation

Cite this

MacLeod, A. M., Minford, E. J., King, D. J., Dawson, A. A., Bennett, N. B., & Catto, G. R. (1987). Non-cytotoxic antibodies in chronic lymphocytic leukaemia. Journal of Clinical Pathology, 40(7), 766-70.

Non-cytotoxic antibodies in chronic lymphocytic leukaemia. / MacLeod, A M; Minford, E J; King, D J; Dawson, A A; Bennett, N B; Catto, G R.

In: Journal of Clinical Pathology, Vol. 40, No. 7, 01.07.1987, p. 766-70.

Research output: Contribution to journalArticle

MacLeod, AM, Minford, EJ, King, DJ, Dawson, AA, Bennett, NB & Catto, GR 1987, 'Non-cytotoxic antibodies in chronic lymphocytic leukaemia', Journal of Clinical Pathology, vol. 40, no. 7, pp. 766-70.
MacLeod AM, Minford EJ, King DJ, Dawson AA, Bennett NB, Catto GR. Non-cytotoxic antibodies in chronic lymphocytic leukaemia. Journal of Clinical Pathology. 1987 Jul 1;40(7):766-70.
MacLeod, A M ; Minford, E J ; King, D J ; Dawson, A A ; Bennett, N B ; Catto, G R. / Non-cytotoxic antibodies in chronic lymphocytic leukaemia. In: Journal of Clinical Pathology. 1987 ; Vol. 40, No. 7. pp. 766-70.
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AB - Non-cytotoxic Fc receptor blocking antibodies against autologous B lymphocytes were sought in sera from patients with chronic lymphocytic leukaemia (CLL), using a rosette inhibition assay. They were found in 11 of 52 (21%) of patients with CLL, but were not associated with previous blood transfusion or pregnancy, suggesting that they were unlikely to have resulted from allogeneic stimulation. Fc receptor blockade was more commonly detected in sera from patients with stage B rather than stage A CLL (Binet classification), though this did not achieve significance beyond the 90% level, and it was noted in 62.5% of those with lymphocyte doubling times of less than one year, compared with 36.3% of those whose lymphocyte doubling time was more than one year. The results indicate that autologous Fc receptor blocking antibody activity occurs in sera from patients with CLL, is more likely to be generated by the tumour itself than by allogeneic stimulation, and is associated with increased tumour load. Such antibodies may permit tolerance of tumour by the host.

KW - Autoantibodies

KW - B-Lymphocytes

KW - Binding, Competitive

KW - Blood Transfusion

KW - Female

KW - Humans

KW - Leukemia, Lymphoid

KW - Leukocyte Count

KW - Male

KW - Middle Aged

KW - Mitosis

KW - Neoplasm Staging

KW - Receptors, Fc

KW - Rosette Formation

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JO - Journal of Clinical Pathology

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