TY - JOUR
T1 - Non-specific immune responses in families of Atlantic salmon, Salmo salar, exhibiting differential resistance to furunculosis
AU - Marsden, M. J.
AU - Freeman, L. C.
AU - Cox, D.
AU - Secombes, C. J.
PY - 1996/10/30
Y1 - 1996/10/30
N2 -
A variety of non-specific humoral and cellular immune-parameters were investigated in five families of farmed Atlantic salmon, Salmo salar, known to exhibit differential susceptibilities to furunculosis in the field (fishfarm) situation. Non-specific phagocyte functions, such as respiratory burst activity and migration, were not found to be significantly different between resistant and susceptible families. Both complement and non-α
2
macroglobulin (α
2
m)-antiprotease activity were found to be higher in families of salmon resistant to Aeromonas salmonicida, however, these differences were not significant. Nevertheless, significant (P < 0.05) inverse correlations between both non-specific humoral factors and furunculosis mortalities in two independent data sets were observed. Based on the above observations, both complement and non-α
2
m-antiprotease activities appear to play a role in resistance against A. salmonicida.
AB -
A variety of non-specific humoral and cellular immune-parameters were investigated in five families of farmed Atlantic salmon, Salmo salar, known to exhibit differential susceptibilities to furunculosis in the field (fishfarm) situation. Non-specific phagocyte functions, such as respiratory burst activity and migration, were not found to be significantly different between resistant and susceptible families. Both complement and non-α
2
macroglobulin (α
2
m)-antiprotease activity were found to be higher in families of salmon resistant to Aeromonas salmonicida, however, these differences were not significant. Nevertheless, significant (P < 0.05) inverse correlations between both non-specific humoral factors and furunculosis mortalities in two independent data sets were observed. Based on the above observations, both complement and non-α
2
m-antiprotease activities appear to play a role in resistance against A. salmonicida.
KW - Aeromonas salmonicida
KW - Antiprotease
KW - Atlantic salmon
KW - Complement
KW - Differential resistance
KW - Immune responses
UR - http://www.scopus.com/inward/record.url?scp=0030607357&partnerID=8YFLogxK
U2 - 10.1016/S0044-8486(96)01358-0
DO - 10.1016/S0044-8486(96)01358-0
M3 - Article
AN - SCOPUS:0030607357
SN - 0044-8486
VL - 146
SP - 1
EP - 16
JO - Aquaculture
JF - Aquaculture
IS - 1-2
ER -