Oestrogen receptor beta in breast cancer: good, bad or still too early to tell?

Research output: Contribution to journalReview article

73 Citations (Scopus)

Abstract

Two oestrogen receptors (ERs), ER alpha and ER beta, have been identified. ER alpha is by far the better characterized and is an established predictive marker in breast cancer which influences decisions on whether or not to give adjuvant anti-oestrogens, such as tamoxifen. In contrast, the function of ER beta in breast pathobiology is unclear, partly because most studies have focused on its mRNA rather than the protein. In this review, the significance of ER beta in the human breast is reviewed with respect to recent literature and its possible implications are discussed.

Original languageEnglish
Pages (from-to)143-7
Number of pages5
JournalThe Journal of pathology
Volume197
Issue number2
DOIs
Publication statusPublished - Jun 2002

Fingerprint

Estrogen Receptor beta
Breast
Breast Neoplasms
Tamoxifen
Estrogen Receptors
Estrogens
Messenger RNA
Proteins

Keywords

  • Biomarkers, Tumor
  • Breast Neoplasms
  • Estrogen Receptor beta
  • Female
  • Humans
  • Neoplasm Proteins
  • Prognosis
  • Receptors, Estrogen
  • Journal Article
  • Review

Cite this

Oestrogen receptor beta in breast cancer : good, bad or still too early to tell? / Speirs, Valerie.

In: The Journal of pathology, Vol. 197, No. 2, 06.2002, p. 143-7.

Research output: Contribution to journalReview article

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abstract = "Two oestrogen receptors (ERs), ER alpha and ER beta, have been identified. ER alpha is by far the better characterized and is an established predictive marker in breast cancer which influences decisions on whether or not to give adjuvant anti-oestrogens, such as tamoxifen. In contrast, the function of ER beta in breast pathobiology is unclear, partly because most studies have focused on its mRNA rather than the protein. In this review, the significance of ER beta in the human breast is reviewed with respect to recent literature and its possible implications are discussed.",
keywords = "Biomarkers, Tumor, Breast Neoplasms, Estrogen Receptor beta, Female, Humans, Neoplasm Proteins, Prognosis, Receptors, Estrogen, Journal Article, Review",
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KW - Neoplasm Proteins

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