On the Formation of Digits and Joints during Limb Development

Tom W. Hiscock; Patrick Tschopp; Clifford J. Tabin

doi:10.1016/j.devcel.2017.04.021

On the Formation of Digits and Joints during Limb Development

Tom W. Hiscock, Patrick Tschopp, Clifford J. Tabin^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

27 Citations (Scopus)

Abstract

Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.

Original language	English
Pages (from-to)	459-465
Number of pages	7
Journal	Developmental Cell
Volume	41
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2017.04.021
Publication status	Published - 5 Jun 2017
Externally published	Yes

Bibliographical note

Acknowledgments: We thank Marian Ros and Susan Mackem for helpful discussions and Susan Mackem for sharing data ahead of publication. This work was supported by a grant from the NIH, R37 HD032443 (to C.J.T.), and the Swiss National Science Foundation, Advanced Postdoc. Mobility fellowship P300P3_158525 (to P.T.).

Keywords

digit specification
joint formation
Turing mechanism

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10.1016/j.devcel.2017.04.021Licence: Other

Cite this

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title = "On the Formation of Digits and Joints during Limb Development",

abstract = "Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.",

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AU - Tschopp, Patrick

AU - Tabin, Clifford J.

N1 - Acknowledgments: We thank Marian Ros and Susan Mackem for helpful discussions and Susan Mackem for sharing data ahead of publication. This work was supported by a grant from the NIH, R37 HD032443 (to C.J.T.), and the Swiss National Science Foundation, Advanced Postdoc. Mobility fellowship P300P3_158525 (to P.T.).

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N2 - Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.

AB - Critical steps in forming the vertebrate limb include the positioning of digits and the positioning of joints within each digit. Recent studies have proposed that the iterative series of digits is established by a Turing-like mechanism generating stripes of chondrogenic domains. However, re-examination of available data suggest that digits are actually patterned as evenly spaced spots, not stripes, which then elongate into rod-shaped digit rays by incorporating new cells at their tips. Moreover, extension of the digit rays and the patterning of the joints occur simultaneously at the distal tip, implying that an integrated model is required to fully understand these processes.

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KW - Turing mechanism

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On the Formation of Digits and Joints during Limb Development

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Thomas Hiscock

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On the Formation of Digits and Joints during Limb Development

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Thomas Hiscock

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