One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor

Michael Simpson, Laurent Alain Claude Trembleau, Richard, W. Cheyne, Timothy Andrew Davies Smith

Research output: Contribution to journalArticle

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Abstract

The biotin-avidin affinity system is exploited in pre-targeted imaging using avidin-conjugated antibodies. 18F-FDG is available at all PET centres. 18F-FDG forms oximes by reaction with oxyamine. Herein we describe the synthesis of oxyamine-funtionalised biotin, its 18F-labelling by conjugation with 18F-FDG and confirm its ability to interact with avidin. © 2010 Elsevier Ltd.

Original languageEnglish
Pages (from-to)418-422
Number of pages5
JournalApplied Radiation and Isotopes
Volume69
Issue number2
Early online date27 Oct 2010
DOIs
Publication statusPublished - Feb 2011

Keywords

  • 18F-FDG
  • Biotin
  • Avidin
  • Pre-target

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