The biotin-avidin affinity system is exploited in pre-targeted imaging using avidin-conjugated antibodies. 18F-FDG is available at all PET centres. 18F-FDG forms oximes by reaction with oxyamine. Herein we describe the synthesis of oxyamine-funtionalised biotin, its 18F-labelling by conjugation with 18F-FDG and confirm its ability to interact with avidin. © 2010 Elsevier Ltd.
Simpson, M., Trembleau, L. A. C., Cheyne, R. W., & Smith, T. A. D. (2011). One-pot production of 18F-biotin by conjugation with 18F-FDG for pre-targeted imaging: Synthesis and radio-labelling of a PEGylated precursor. Applied Radiation and Isotopes, 69(2), 418-422. https://doi.org/10.1016/j.apradiso.2010.10.012