Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system

Elmir Omerovic; Rodolfo Citro; Eduardo Bossone; Bjorn Redfors; Johannes Backs; Bastian Bruns; Michele Ciccarelli; Liam S. Couch; Dana Dawson; Guido Grassi; Massimo Iacoviello; Guido Parodi; Birke Schneider; Christian Templin; Jelena R. Ghadri; Thomas Thum; Ovidiu Chioncel; C. Gabriele Tocchetti; Jolanda van der Velden; Stephane Heymans; Alexander R. Lyon

doi:10.1002/ejhf.2400

Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system

Elmir Omerovic^* (Corresponding Author), Rodolfo Citro, Eduardo Bossone, Bjorn Redfors, Johannes Backs, Bastian Bruns, Michele Ciccarelli, Liam S. Couch, Dana Dawson, Guido Grassi, Massimo Iacoviello, Guido Parodi, Birke Schneider, Christian Templin, Jelena R. Ghadri, Thomas Thum, Ovidiu Chioncel, C. Gabriele Tocchetti, Jolanda van der Velden, Stephane HeymansAlexander R. Lyon

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

2 Downloads (Pure)

Abstract

This is the first part of a scientific statement from the Heart Failure Association (HFA) of the European Society of Cardiology focused upon the pathophysiology of Takotsubo syndrome and is complimentary to the previous HFA position statement on Takotsubo syndrome which focused upon clinical management. In part 1 we provide an overview of the pathophysiology of Takotsubo syndrome and fundamental questions to consider. We then review and discuss the central role of catecholamines and the sympathetic nervous system in the pathophysiology, and the direct effects of high surges in catecholamines upon myocardial biology including beta-adrenergic receptor signalling, G-protein coupled receptor kinases, cardiomyocyte calcium physiology, myofilament physiology, cardiomyocyte gene expression, myocardial electrophysiology and arrhythmogenicity, myocardial inflammation, metabolism and energetics. The integrated effects upon ventricular haemodynamics are discussed and integrated into the pathophysiological model.

Original language	English
Pages (from-to)	257-273
Number of pages	17
Journal	European Journal of Heart Failure
Volume	24
Issue number	2
Early online date	16 Feb 2022
DOIs	https://doi.org/10.1002/ejhf.2400
Publication status	Published - 23 Feb 2022

Bibliographical note

Acknowledgements
S.H. acknowledges the support from the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2016-Early HFPEF, 2015-10, and CVON She-PREDICTS, grant 2017-21, CVON-Arena-PRIME, European Union Commission’s Seventh Framework programme under grant agreement n. 305507 (HOMAGE) and n. 602904 (FIBROTAR-GETS). D.D. acknowledges support from the British Heart Foundation grants PG/15/108/31928 and FS/16/39/32174, the Josephine Lansdell British Medical Association 2015Award and Tenovus Scotland, G13.10. A.R.L. is supported by the Leducq Foundation Cardio-Oncology Network. Conflict of interest: none declared

Keywords

Takotsubo syndrome
Pathophysiology
Catecholamine
Beta-adrenergic signalling
G-protein coupled receptor kinase
Electrophysiology
Inflammation
Metabolism
TAKO-TSUBO CARDIOMYOPATHY
COUPLED-RECEPTOR KINASE-5
STRESS-INDUCED CARDIOMYOPATHY
LIFE-THREATENING ARRHYTHMIAS
QT INTERVAL PROLONGATION
BALLOONING SYNDROME
CLINICAL-FEATURES
VENTRICULAR DYSFUNCTION
NATRIURETIC PEPTIDE
DIAGNOSTIC-CRITERIA

Access to Document

10.1002/ejhf.2400Licence: CC BY-NC-ND

Omerovic _et_al_ Pathophysiology_Takotsubo_ syndrome_European_Journal_of_Heart_Failure_vor
© 2021 The Authors. European Journal of Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made https://creativecommons.org/licenses/by-nc-nd/4.0/
Final published version, 5.25 MBLicence: CC BY-NC-ND

Fingerprint

Dive into the research topics of 'Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system'. Together they form a unique fingerprint.

Cite this

Omerovic, E., Citro, R., Bossone, E., Redfors, B., Backs, J., Bruns, B., Ciccarelli, M., Couch, L. S., Dawson, D., Grassi, G., Iacoviello, M., Parodi, G., Schneider, B., Templin, C., Ghadri, J. R., Thum, T., Chioncel, O., Tocchetti, C. G., van der Velden, J., ... Lyon, A. R. (2022). Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system. European Journal of Heart Failure, 24(2), 257-273. https://doi.org/10.1002/ejhf.2400

Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system. / Omerovic, Elmir (Corresponding Author); Citro, Rodolfo; Bossone, Eduardo et al.
In: European Journal of Heart Failure, Vol. 24, No. 2, 23.02.2022, p. 257-273.

Research output: Contribution to journal › Article › peer-review

Omerovic, E, Citro, R, Bossone, E, Redfors, B, Backs, J, Bruns, B, Ciccarelli, M, Couch, LS, Dawson, D, Grassi, G, Iacoviello, M, Parodi, G, Schneider, B, Templin, C, Ghadri, JR, Thum, T, Chioncel, O, Tocchetti, CG, van der Velden, J, Heymans, S & Lyon, AR 2022, 'Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system', European Journal of Heart Failure, vol. 24, no. 2, pp. 257-273. https://doi.org/10.1002/ejhf.2400

Omerovic E, Citro R, Bossone E, Redfors B, Backs J, Bruns B et al. Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system. European Journal of Heart Failure. 2022 Feb 23;24(2):257-273. Epub 2022 Feb 16. doi: 10.1002/ejhf.2400

Omerovic, Elmir ; Citro, Rodolfo ; Bossone, Eduardo et al. / Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1 : overview and the central role for catecholamines and sympathetic nervous system. In: European Journal of Heart Failure. 2022 ; Vol. 24, No. 2. pp. 257-273.

@article{25d9a20fc655497fbe60b451f5481692,

title = "Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1: overview and the central role for catecholamines and sympathetic nervous system",

abstract = "This is the first part of a scientific statement from the Heart Failure Association (HFA) of the European Society of Cardiology focused upon the pathophysiology of Takotsubo syndrome and is complimentary to the previous HFA position statement on Takotsubo syndrome which focused upon clinical management. In part 1 we provide an overview of the pathophysiology of Takotsubo syndrome and fundamental questions to consider. We then review and discuss the central role of catecholamines and the sympathetic nervous system in the pathophysiology, and the direct effects of high surges in catecholamines upon myocardial biology including beta-adrenergic receptor signalling, G-protein coupled receptor kinases, cardiomyocyte calcium physiology, myofilament physiology, cardiomyocyte gene expression, myocardial electrophysiology and arrhythmogenicity, myocardial inflammation, metabolism and energetics. The integrated effects upon ventricular haemodynamics are discussed and integrated into the pathophysiological model.",

keywords = "Takotsubo syndrome, Pathophysiology, Catecholamine, Beta-adrenergic signalling, G-protein coupled receptor kinase, Electrophysiology, Inflammation, Metabolism, TAKO-TSUBO CARDIOMYOPATHY, COUPLED-RECEPTOR KINASE-5, STRESS-INDUCED CARDIOMYOPATHY, LIFE-THREATENING ARRHYTHMIAS, QT INTERVAL PROLONGATION, BALLOONING SYNDROME, CLINICAL-FEATURES, VENTRICULAR DYSFUNCTION, NATRIURETIC PEPTIDE, DIAGNOSTIC-CRITERIA",

author = "Elmir Omerovic and Rodolfo Citro and Eduardo Bossone and Bjorn Redfors and Johannes Backs and Bastian Bruns and Michele Ciccarelli and Couch, {Liam S.} and Dana Dawson and Guido Grassi and Massimo Iacoviello and Guido Parodi and Birke Schneider and Christian Templin and Ghadri, {Jelena R.} and Thomas Thum and Ovidiu Chioncel and Tocchetti, {C. Gabriele} and {van der Velden}, Jolanda and Stephane Heymans and Lyon, {Alexander R.}",

note = "Acknowledgements S.H. acknowledges the support from the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2016-Early HFPEF, 2015-10, and CVON She-PREDICTS, grant 2017-21, CVON-Arena-PRIME, European Union Commission{\textquoteright}s Seventh Framework programme under grant agreement n. 305507 (HOMAGE) and n. 602904 (FIBROTAR-GETS). D.D. acknowledges support from the British Heart Foundation grants PG/15/108/31928 and FS/16/39/32174, the Josephine Lansdell British Medical Association 2015Award and Tenovus Scotland, G13.10. A.R.L. is supported by the Leducq Foundation Cardio-Oncology Network. Conflict of interest: none declared",

year = "2022",

month = feb,

day = "23",

doi = "10.1002/ejhf.2400",

language = "English",

volume = "24",

pages = "257--273",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "Wiley",

number = "2",

}

TY - JOUR

T1 - Pathophysiology of Takotsubo syndrome - a joint scientific statement from the Heart Failure Association Takotsubo Syndrome Study Group and Myocardial Function Working Group of the European Society of Cardiology - Part 1

T2 - overview and the central role for catecholamines and sympathetic nervous system

AU - Omerovic, Elmir

AU - Citro, Rodolfo

AU - Bossone, Eduardo

AU - Redfors, Bjorn

AU - Backs, Johannes

AU - Bruns, Bastian

AU - Ciccarelli, Michele

AU - Couch, Liam S.

AU - Dawson, Dana

AU - Grassi, Guido

AU - Iacoviello, Massimo

AU - Parodi, Guido

AU - Schneider, Birke

AU - Templin, Christian

AU - Ghadri, Jelena R.

AU - Thum, Thomas

AU - Chioncel, Ovidiu

AU - Tocchetti, C. Gabriele

AU - van der Velden, Jolanda

AU - Heymans, Stephane

AU - Lyon, Alexander R.

N1 - Acknowledgements S.H. acknowledges the support from the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2016-Early HFPEF, 2015-10, and CVON She-PREDICTS, grant 2017-21, CVON-Arena-PRIME, European Union Commission’s Seventh Framework programme under grant agreement n. 305507 (HOMAGE) and n. 602904 (FIBROTAR-GETS). D.D. acknowledges support from the British Heart Foundation grants PG/15/108/31928 and FS/16/39/32174, the Josephine Lansdell British Medical Association 2015Award and Tenovus Scotland, G13.10. A.R.L. is supported by the Leducq Foundation Cardio-Oncology Network. Conflict of interest: none declared

PY - 2022/2/23

Y1 - 2022/2/23

N2 - This is the first part of a scientific statement from the Heart Failure Association (HFA) of the European Society of Cardiology focused upon the pathophysiology of Takotsubo syndrome and is complimentary to the previous HFA position statement on Takotsubo syndrome which focused upon clinical management. In part 1 we provide an overview of the pathophysiology of Takotsubo syndrome and fundamental questions to consider. We then review and discuss the central role of catecholamines and the sympathetic nervous system in the pathophysiology, and the direct effects of high surges in catecholamines upon myocardial biology including beta-adrenergic receptor signalling, G-protein coupled receptor kinases, cardiomyocyte calcium physiology, myofilament physiology, cardiomyocyte gene expression, myocardial electrophysiology and arrhythmogenicity, myocardial inflammation, metabolism and energetics. The integrated effects upon ventricular haemodynamics are discussed and integrated into the pathophysiological model.

AB - This is the first part of a scientific statement from the Heart Failure Association (HFA) of the European Society of Cardiology focused upon the pathophysiology of Takotsubo syndrome and is complimentary to the previous HFA position statement on Takotsubo syndrome which focused upon clinical management. In part 1 we provide an overview of the pathophysiology of Takotsubo syndrome and fundamental questions to consider. We then review and discuss the central role of catecholamines and the sympathetic nervous system in the pathophysiology, and the direct effects of high surges in catecholamines upon myocardial biology including beta-adrenergic receptor signalling, G-protein coupled receptor kinases, cardiomyocyte calcium physiology, myofilament physiology, cardiomyocyte gene expression, myocardial electrophysiology and arrhythmogenicity, myocardial inflammation, metabolism and energetics. The integrated effects upon ventricular haemodynamics are discussed and integrated into the pathophysiological model.

KW - Takotsubo syndrome

KW - Pathophysiology

KW - Catecholamine

KW - Beta-adrenergic signalling

KW - G-protein coupled receptor kinase

KW - Electrophysiology

KW - Inflammation

KW - Metabolism

KW - TAKO-TSUBO CARDIOMYOPATHY

KW - COUPLED-RECEPTOR KINASE-5

KW - STRESS-INDUCED CARDIOMYOPATHY

KW - LIFE-THREATENING ARRHYTHMIAS

KW - QT INTERVAL PROLONGATION

KW - BALLOONING SYNDROME

KW - CLINICAL-FEATURES

KW - VENTRICULAR DYSFUNCTION

KW - NATRIURETIC PEPTIDE

KW - DIAGNOSTIC-CRITERIA

U2 - 10.1002/ejhf.2400

DO - 10.1002/ejhf.2400

M3 - Article

SN - 1388-9842

VL - 24

SP - 257

EP - 273

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

IS - 2

ER -