Patterns of drug prescription in a geriatric evaluation and management unit as compared with the general medical wards. A randomised study.

I. Saltvedt, O. Spigset, S. Ruths, Peter Fayers, S. Kaasa, O. Sletvold

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Objective: This study's objective was to determine whether patients treated in a geriatric evaluation and management unit (GEMU) had a more appropriate drug profile than patients treated in the general medical wards (MW). Methods: Frail elderly patients admitted as emergencies to the medical department were randomised to treatment in the GEMU (n=127) or MW (n=127). Drugs used at inclusion and discharge were registered retrospectively and analysed with regard to polypharmacy, number of drugs withdrawn or started, potential drug-drug interactions (DDIs), number of anticholinergic drugs prescribed, and the number of inappropriate drug prescriptions according to Beers' criteria. Utilisation of psychotropic and cardiovascular drugs was compared in detail according to prespecified hypotheses. Results: The number of patients with polypharmacy did not differ significantly between the GEMU and MW. The median number of scheduled drugs withdrawn per patient was higher in the GEMU than in the MW (p=0.005). Drugs with anticholinergic effects (p=0.003); cardiovascular drugs (p < 0.001), particularly digitalis glycosides (p < 0.001); and antipsychotic drugs (p=0.009) were withdrawn more often in the GEMU. The median number of scheduled drugs started was higher in the GEMU than in the MW (p=0.03). In particular, antidepressants (p < 0.001) and estriol (p=0.001) were started more often in the GEMU than in the MW. Fewer GEMU than MW patients had potential DDIs at discharge (p=0.009). Conclusion: Drug treatment in the GEMU as compared with the MW was more appropriate in terms of prescription of fewer drugs with anticholinergic effects and fewer potential DDIs. There were distinct differences in treatment patterns of cardiovascular and psychotropic drugs.

Original languageEnglish
Pages (from-to)921-928
Number of pages8
JournalEuropean Journal of Clinical Pharmacology
Volume62
Issue number12
Early online date24 Nov 2005
DOIs
Publication statusPublished - Dec 2005

Keywords

  • drug prescribing
  • geriatric
  • hospital
  • randomised clinical study
  • ELDERLY-PATIENTS
  • OLDER PATIENTS
  • POTENTIALLY INAPPROPRIATE
  • HOSPITAL-ADMISSIONS
  • EXPLICIT CRITERIA
  • BEERS CRITERIA
  • ITALIAN GROUP
  • CARE
  • INPATIENTS
  • OUTCOMES

Cite this

Patterns of drug prescription in a geriatric evaluation and management unit as compared with the general medical wards. A randomised study. / Saltvedt, I.; Spigset, O.; Ruths, S.; Fayers, Peter; Kaasa, S.; Sletvold, O.

In: European Journal of Clinical Pharmacology, Vol. 62, No. 12, 12.2005, p. 921-928.

Research output: Contribution to journalArticle

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AU - Spigset, O.

AU - Ruths, S.

AU - Fayers, Peter

AU - Kaasa, S.

AU - Sletvold, O.

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N2 - Objective: This study's objective was to determine whether patients treated in a geriatric evaluation and management unit (GEMU) had a more appropriate drug profile than patients treated in the general medical wards (MW). Methods: Frail elderly patients admitted as emergencies to the medical department were randomised to treatment in the GEMU (n=127) or MW (n=127). Drugs used at inclusion and discharge were registered retrospectively and analysed with regard to polypharmacy, number of drugs withdrawn or started, potential drug-drug interactions (DDIs), number of anticholinergic drugs prescribed, and the number of inappropriate drug prescriptions according to Beers' criteria. Utilisation of psychotropic and cardiovascular drugs was compared in detail according to prespecified hypotheses. Results: The number of patients with polypharmacy did not differ significantly between the GEMU and MW. The median number of scheduled drugs withdrawn per patient was higher in the GEMU than in the MW (p=0.005). Drugs with anticholinergic effects (p=0.003); cardiovascular drugs (p < 0.001), particularly digitalis glycosides (p < 0.001); and antipsychotic drugs (p=0.009) were withdrawn more often in the GEMU. The median number of scheduled drugs started was higher in the GEMU than in the MW (p=0.03). In particular, antidepressants (p < 0.001) and estriol (p=0.001) were started more often in the GEMU than in the MW. Fewer GEMU than MW patients had potential DDIs at discharge (p=0.009). Conclusion: Drug treatment in the GEMU as compared with the MW was more appropriate in terms of prescription of fewer drugs with anticholinergic effects and fewer potential DDIs. There were distinct differences in treatment patterns of cardiovascular and psychotropic drugs.

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KW - POTENTIALLY INAPPROPRIATE

KW - HOSPITAL-ADMISSIONS

KW - EXPLICIT CRITERIA

KW - BEERS CRITERIA

KW - ITALIAN GROUP

KW - CARE

KW - INPATIENTS

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JO - European Journal of Clinical Pharmacology

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