Objective: It is uncertain whether persons with chronic widespread pain (CWP) experience premature mortality. Using the largest study conducted, we determine whether such a relationship exists, estimate its magnitude and establish what factors mediate any relationship. Methods: UK Biobank, a cohort study of 0.5 million people aged 40-69 years, recruited throughout Great Britain 2006-10. Participants reporting “pain all over the body” for >3 months were compared with persons without chronic pain.. Information on death (with cause) was available until mid-2015. We incorporated these results in a meta-analysis with other published reports to calculate a pooled estimate of excess risk.. Results: 7130 participants reported CWP and they experienced excess mortality (Mortality Risk Ratio 2.43, 95% Confidence Interval 2.17, 2.72). Specific causes of death in excess were cancer (1.73adjusted age and sex; 1.46, 2.05); cardiovascular (3.24adjusted age and sex; 2.55, 4.11); respiratory (5.66adjusted age and sex; 4.00, 8.03); and other disease-related causes (4.04adjusted age and sex; 3.05, 5.34). Excess risk was substantially reduced after adjustment for low levels of physical activity, high body mass index (BMI), poor quality diet and smoking. In meta-analysis, all studies showed significant excess all-cause ( combined estimate 1.59 (1.05, 2.42)). cardiovascular and cancer mortality. Conclusions: Evidence is now clear that persons with CWP experience excess mortality. UK Biobank results considerably reduce uncertainty around the magnitude of excess risk, and are consistent with the excess being explained by adverse lifestyle factors, which could be targeted in the management of such patients.