Physical health-related quality of life predicts stroke in the EPIC-Norfolk

P K Myint, P G Surtees, N W J Wainwright, R N Luben, A A Welch, S A Bingham, N J Wareham, K-T Khaw

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: To examine the relationship between Short Form (SF)-36 physical functional health-related quality of life and incident stroke.

METHODS: A total of 13,615 men and women participating in the European Prospective Investigation into Cancer-Norfolk who were free of stroke, myocardial infarction, and cancer at baseline were included in the study. Participants completed a health and lifestyle questionnaire and attended a health examination during 1993 to 1997. Self-reported physical functional health was assessed using physical component summary scores of SF-36 18 months later. Stroke incidence was ascertained by death certification and hospital record linkage up to 2005.

RESULTS: There were 244 incident strokes (total person years = 99,191). People who reported better physical functional health had significantly lower risk of incident stroke. Using Cox proportional hazard models adjusting for age, sex, body mass index, systolic blood pressure, cholesterol, smoking, diabetes, physical activity, social class, alcohol consumption, and respiratory function, men and women who were in the top quartile of SF-36 physical component summary scores had half the risk of stroke (RR = 0.50 [0.31, 0.78]) compared to the people in the bottom quartile. The relationships remained unchanged after excluding strokes occurring within the first 2 years of follow-up.

CONCLUSIONS: Physical functional health-related quality of life measured as Short Form-36 predicts subsequent stroke risk independently of known risk factors in a general population. Poor physical functional health may indicate a high-risk population for stroke who may benefit most from targeted preventive interventions such as management of known risk factors.

Original languageEnglish
Pages (from-to)2243-2248
Number of pages6
JournalNeurology
Volume69
Issue number24
DOIs
Publication statusPublished - 11 Dec 2007

Fingerprint

Stroke
Quality of Life
Health
Blood Pressure
Death Certificates
Hospital Records
Certification
Proportional Hazards Models
Social Class
Alcohol Drinking
Population
Life Style
Neoplasms
Body Mass Index
Smoking
Myocardial Infarction
Cholesterol
Exercise
Incidence

Keywords

  • Adult
  • Aged
  • Female
  • Follow-Up Studies
  • Health Status Indicators
  • Humans
  • Male
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Quality of Life
  • Risk Factors
  • Stroke

Cite this

Myint, P. K., Surtees, P. G., Wainwright, N. W. J., Luben, R. N., Welch, A. A., Bingham, S. A., ... Khaw, K-T. (2007). Physical health-related quality of life predicts stroke in the EPIC-Norfolk. Neurology, 69(24), 2243-2248. https://doi.org/10.1212/01.wnl.0000296010.21252.78

Physical health-related quality of life predicts stroke in the EPIC-Norfolk. / Myint, P K; Surtees, P G; Wainwright, N W J; Luben, R N; Welch, A A; Bingham, S A; Wareham, N J; Khaw, K-T.

In: Neurology, Vol. 69, No. 24, 11.12.2007, p. 2243-2248.

Research output: Contribution to journalArticle

Myint, PK, Surtees, PG, Wainwright, NWJ, Luben, RN, Welch, AA, Bingham, SA, Wareham, NJ & Khaw, K-T 2007, 'Physical health-related quality of life predicts stroke in the EPIC-Norfolk' Neurology, vol. 69, no. 24, pp. 2243-2248. https://doi.org/10.1212/01.wnl.0000296010.21252.78
Myint, P K ; Surtees, P G ; Wainwright, N W J ; Luben, R N ; Welch, A A ; Bingham, S A ; Wareham, N J ; Khaw, K-T. / Physical health-related quality of life predicts stroke in the EPIC-Norfolk. In: Neurology. 2007 ; Vol. 69, No. 24. pp. 2243-2248.
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