Polyamine Analogues and Derivatives as Potential Anticancer Agents

Lynda Ralton, Charles Bestwick, Paul Thoon Lin Kong

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Polyamines exert an essential role in cell proliferation and development. The cellular concentration of these small organic molecules is tightly regulated and their cellular uptake actively modulated via the polyamine transporters (PAT). The apparent critical influence of polyamines on cell development and survival and their recognition by the PAT have both led to polyamines being increasingly considered for the development of a range of chemotherapeutic agents. In this review, we discuss how polyamine chains attached to cytotoxic molecules have been used to aid their transport into tumour cells. Furthermore, the ability of polyamine analogues and derivatives to modulate polyamine biosynthesis and apoptosis induction is assessed. Specifically, novel intercalating naphthalimido compounds bearing an amino or polyamine chains are highlighted.
Original languageEnglish
Pages (from-to)179-191
Number of pages13
JournalCurrent Bioactive Compounds
Volume3
Issue number3
Publication statusPublished - Sep 2007

Keywords

  • ornithine decarboxylase
  • polyamine transporters
  • Apoptosis
  • hydrogen peroxide
  • Oligoamines
  • Naphthalimide Chromophore

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