Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer

Devasena Anantharaman; Manuela Marron; Pagona Lagiou; Evangelia Samoli; Wolfgang Ahrens; Hermann Pohlabeln; Alena Slamova; Miriam Schejbalova; Franco Merletti; Lorenzo Richiardi; Kristina Kjaerheim; Xavier Castellsague; Antonio Agudo; Renato Talamini; Luigi Barzan; Tatiana MacFarlane; Martin Tickle; Lorenzo Simonato; Cristina Canova; David I Conway; Patricia A McKinney; Peter Thomson; Ariana Znaor; Claire M Healy; Bernard E McCartan; Mia Hashibe; Paul Brennan; Gary J Macfarlane

doi:10.1016/j.oraloncology.2011.05.004

Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer

Devasena Anantharaman, Manuela Marron, Pagona Lagiou, Evangelia Samoli, Wolfgang Ahrens, Hermann Pohlabeln, Alena Slamova, Miriam Schejbalova, Franco Merletti, Lorenzo Richiardi, Kristina Kjaerheim, Xavier Castellsague, Antonio Agudo, Renato Talamini, Luigi Barzan, Tatiana MacFarlane, Martin Tickle, Lorenzo Simonato, Cristina Canova, David I ConwayPatricia A McKinney, Peter Thomson, Ariana Znaor, Claire M Healy, Bernard E McCartan, Mia Hashibe, Paul Brennan, Gary J Macfarlane

International Agency for Research on Cancer

Research output: Contribution to journal › Article › peer-review

135 Citations (Scopus)

Abstract

Tobacco and alcohol are major risk factors for upper aerodigestive tract (UADT) cancer and significant variation is observed in UADT cancer rates across Europe. We have estimated the proportion of UADT cancer burden explained by tobacco and alcohol and how this varies with the incidence rates across Europe, cancer sub-site, gender and age. This should help estimate the minimum residual burden of other risk factors to UADT cancer, including human papillomavirus. We analysed 1981 UADT cancer cases and 1993 controls from the ARCAGE multicentre study. We estimated the population attributable risk (PAR) of tobacco alone, alcohol alone and their joint effect. Tobacco and alcohol together explained 73% of UADT cancer burden of which nearly 29% was explained by smoking alone, less than 1% due to alcohol on its own and 44% by the joint effect of tobacco and alcohol. Tobacco and alcohol together explained a larger proportion of hypopharyngeal/laryngeal cancer (PAR=85%) than oropharyngeal (PAR=74%), esophageal (PAR=67%) and oral cancer (PAR=61%). Tobacco and alcohol together explain only about half of the total UADT cancer burden among women. Geographically, tobacco and alcohol explained a larger proportion of UADT cancer in central (PAR=84%) than southern (PAR=72%) and western Europe (PAR=67%). While the majority of the UADT cancers in Europe are due to tobacco or the joint effect of tobacco and alcohol, our results support a significant role for other risk factors in particular, for oral and oropharyngeal cancers and also for UADT cancers in southern and western Europe.

Original language	English
Pages (from-to)	725-731
Number of pages	7
Journal	Oral Oncology
Volume	47
Issue number	8
Early online date	20 Jun 2011
DOIs	https://doi.org/10.1016/j.oraloncology.2011.05.004
Publication status	Published - Aug 2011

Bibliographical note

Keywords

adult
alcohol drinking
case-control studies
esophageal neoplasms
Europe
female
humans
incidence
male
middle aged
mouth neoplasms
otorhinolaryngologic neoplasms
risk factors
smoking
upper aerodigestive tract cancer
ARCAGE study
population attributable risk
tobacco
alcohol

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.oraloncology.2011.05.004

Cite this

Anantharaman, D., Marron, M., Lagiou, P., Samoli, E., Ahrens, W., Pohlabeln, H., Slamova, A., Schejbalova, M., Merletti, F., Richiardi, L., Kjaerheim, K., Castellsague, X., Agudo, A., Talamini, R., Barzan, L., MacFarlane, T., Tickle, M., Simonato, L., Canova, C., ... Macfarlane, G. J. (2011). Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer. Oral Oncology, 47(8), 725-731. https://doi.org/10.1016/j.oraloncology.2011.05.004

Anantharaman, D, Marron, M, Lagiou, P, Samoli, E, Ahrens, W, Pohlabeln, H, Slamova, A, Schejbalova, M, Merletti, F, Richiardi, L, Kjaerheim, K, Castellsague, X, Agudo, A, Talamini, R, Barzan, L, MacFarlane, T, Tickle, M, Simonato, L, Canova, C, Conway, DI, McKinney, PA, Thomson, P, Znaor, A, Healy, CM, McCartan, BE, Hashibe, M, Brennan, P & Macfarlane, GJ 2011, 'Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer', Oral Oncology, vol. 47, no. 8, pp. 725-731. https://doi.org/10.1016/j.oraloncology.2011.05.004

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Population attributable risk of tobacco and alcohol for upper aerodigestive tract cancer

Abstract

Bibliographical note

Keywords

UN SDGs

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Cite this