Postmastication digestion factors influence glycemic variability in humans

Viren Ranawana, Miriam E Clegg, Amir Shafat, C Jeya Henry

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The glycemic response (GR) to food is influenced by both intrinsic and extrinsic factors. A consistent observation in GR studies is the wide within- and between-individual variations. The authors hypothesize that between-individual variations in the GR, insulin response (IR) and gastric emptying occur even when food particle size is standardized. Volunteers were tested on 2 nonconsecutive days after an overnight fast in randomized order. On 1 day, the volunteers consumed large (>2000 μm) rice particles, and on the second day, small rice particles (500-1000 μm). Subsequently, gastric emptying using the sodium [(13)C] acetate breath test (for 240 minutes) and GR and IR (for 120 minutes) from finger-prick blood samples were measured. The incremental area under the curve (IAUC) for the GR for small particles varied 45% more compared with whole rice. The small particles elicited a significantly greater GR IAUC than the large particles. The standard deviations associated with the IR IAUC for the small particles was 140% greater than that of the large particles. The total IAUC for IR was also significantly greater for the small particles than the large particles. The between-individual variations associated with gastric emptying times were similar for both samples. The gastric emptying latency phase, lag, and half time were significantly shorter for the small particles. Ingesting small particles causes faster gastric emptying and produces greater glycemic and IRs. Between-individual variations in GR and IR can be observed even when all the food associated factors including ingested particle size (mastication) are controlled for in humans.

Original languageEnglish
Pages (from-to)452-459
Number of pages8
JournalNutrition research (New York, N.Y.)
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 2011

Fingerprint

Gastric Emptying
Digestion
Area Under Curve
Insulin
Particle Size
Food
Volunteers
Intrinsic Factor
Breath Tests
Mastication
Fingers
Acetates
Sodium
Observation
Oryza

Keywords

  • acetates
  • adult
  • area under curve
  • blood glucose
  • breath tests
  • cross-over studies
  • digestion
  • gastric emptying
  • glycemic index
  • humans
  • insulin
  • male
  • mastication
  • Oryza sativa
  • particle size
  • young adult

Cite this

Postmastication digestion factors influence glycemic variability in humans. / Ranawana, Viren; Clegg, Miriam E; Shafat, Amir; Henry, C Jeya.

In: Nutrition research (New York, N.Y.), Vol. 31, No. 6, 06.2011, p. 452-459.

Research output: Contribution to journalArticle

Ranawana, Viren ; Clegg, Miriam E ; Shafat, Amir ; Henry, C Jeya. / Postmastication digestion factors influence glycemic variability in humans. In: Nutrition research (New York, N.Y.). 2011 ; Vol. 31, No. 6. pp. 452-459.
@article{0a6724749f1546968e9cd9b97191dded,
title = "Postmastication digestion factors influence glycemic variability in humans",
abstract = "The glycemic response (GR) to food is influenced by both intrinsic and extrinsic factors. A consistent observation in GR studies is the wide within- and between-individual variations. The authors hypothesize that between-individual variations in the GR, insulin response (IR) and gastric emptying occur even when food particle size is standardized. Volunteers were tested on 2 nonconsecutive days after an overnight fast in randomized order. On 1 day, the volunteers consumed large (>2000 μm) rice particles, and on the second day, small rice particles (500-1000 μm). Subsequently, gastric emptying using the sodium [(13)C] acetate breath test (for 240 minutes) and GR and IR (for 120 minutes) from finger-prick blood samples were measured. The incremental area under the curve (IAUC) for the GR for small particles varied 45{\%} more compared with whole rice. The small particles elicited a significantly greater GR IAUC than the large particles. The standard deviations associated with the IR IAUC for the small particles was 140{\%} greater than that of the large particles. The total IAUC for IR was also significantly greater for the small particles than the large particles. The between-individual variations associated with gastric emptying times were similar for both samples. The gastric emptying latency phase, lag, and half time were significantly shorter for the small particles. Ingesting small particles causes faster gastric emptying and produces greater glycemic and IRs. Between-individual variations in GR and IR can be observed even when all the food associated factors including ingested particle size (mastication) are controlled for in humans.",
keywords = "acetates, adult, area under curve, blood glucose, breath tests, cross-over studies, digestion, gastric emptying, glycemic index, humans, insulin, male, mastication, Oryza sativa, particle size, young adult",
author = "Viren Ranawana and Clegg, {Miriam E} and Amir Shafat and Henry, {C Jeya}",
note = "Crown Copyright {\circledC} 2011. Published by Elsevier Inc. All rights reserved.",
year = "2011",
month = "6",
doi = "10.1016/j.nutres.2011.05.006",
language = "English",
volume = "31",
pages = "452--459",
journal = "Nutrition research (New York, N.Y.)",
issn = "1879-0739",
number = "6",

}

TY - JOUR

T1 - Postmastication digestion factors influence glycemic variability in humans

AU - Ranawana, Viren

AU - Clegg, Miriam E

AU - Shafat, Amir

AU - Henry, C Jeya

N1 - Crown Copyright © 2011. Published by Elsevier Inc. All rights reserved.

PY - 2011/6

Y1 - 2011/6

N2 - The glycemic response (GR) to food is influenced by both intrinsic and extrinsic factors. A consistent observation in GR studies is the wide within- and between-individual variations. The authors hypothesize that between-individual variations in the GR, insulin response (IR) and gastric emptying occur even when food particle size is standardized. Volunteers were tested on 2 nonconsecutive days after an overnight fast in randomized order. On 1 day, the volunteers consumed large (>2000 μm) rice particles, and on the second day, small rice particles (500-1000 μm). Subsequently, gastric emptying using the sodium [(13)C] acetate breath test (for 240 minutes) and GR and IR (for 120 minutes) from finger-prick blood samples were measured. The incremental area under the curve (IAUC) for the GR for small particles varied 45% more compared with whole rice. The small particles elicited a significantly greater GR IAUC than the large particles. The standard deviations associated with the IR IAUC for the small particles was 140% greater than that of the large particles. The total IAUC for IR was also significantly greater for the small particles than the large particles. The between-individual variations associated with gastric emptying times were similar for both samples. The gastric emptying latency phase, lag, and half time were significantly shorter for the small particles. Ingesting small particles causes faster gastric emptying and produces greater glycemic and IRs. Between-individual variations in GR and IR can be observed even when all the food associated factors including ingested particle size (mastication) are controlled for in humans.

AB - The glycemic response (GR) to food is influenced by both intrinsic and extrinsic factors. A consistent observation in GR studies is the wide within- and between-individual variations. The authors hypothesize that between-individual variations in the GR, insulin response (IR) and gastric emptying occur even when food particle size is standardized. Volunteers were tested on 2 nonconsecutive days after an overnight fast in randomized order. On 1 day, the volunteers consumed large (>2000 μm) rice particles, and on the second day, small rice particles (500-1000 μm). Subsequently, gastric emptying using the sodium [(13)C] acetate breath test (for 240 minutes) and GR and IR (for 120 minutes) from finger-prick blood samples were measured. The incremental area under the curve (IAUC) for the GR for small particles varied 45% more compared with whole rice. The small particles elicited a significantly greater GR IAUC than the large particles. The standard deviations associated with the IR IAUC for the small particles was 140% greater than that of the large particles. The total IAUC for IR was also significantly greater for the small particles than the large particles. The between-individual variations associated with gastric emptying times were similar for both samples. The gastric emptying latency phase, lag, and half time were significantly shorter for the small particles. Ingesting small particles causes faster gastric emptying and produces greater glycemic and IRs. Between-individual variations in GR and IR can be observed even when all the food associated factors including ingested particle size (mastication) are controlled for in humans.

KW - acetates

KW - adult

KW - area under curve

KW - blood glucose

KW - breath tests

KW - cross-over studies

KW - digestion

KW - gastric emptying

KW - glycemic index

KW - humans

KW - insulin

KW - male

KW - mastication

KW - Oryza sativa

KW - particle size

KW - young adult

U2 - 10.1016/j.nutres.2011.05.006

DO - 10.1016/j.nutres.2011.05.006

M3 - Article

VL - 31

SP - 452

EP - 459

JO - Nutrition research (New York, N.Y.)

JF - Nutrition research (New York, N.Y.)

SN - 1879-0739

IS - 6

ER -