PRESENCE OF THE BROWN FAT-SPECIFIC MITOCHONDRIAL UNCOUPLING PROTEIN AND IODOTHYRONINE 5'-DEIODINASE ACTIVITY IN SUBCUTANEOUS ADIPOSE-TISSUE OF NEONATAL LAMBS

P  TRAYHURN; M E A  THOMAS; Jackie Duncan; Fergus Nicol; John Arthur

PRESENCE OF THE BROWN FAT-SPECIFIC MITOCHONDRIAL UNCOUPLING PROTEIN AND IODOTHYRONINE 5'-DEIODINASE ACTIVITY IN SUBCUTANEOUS ADIPOSE-TISSUE OF NEONATAL LAMBS

P TRAYHURN, M E A THOMAS, Jackie Duncan, Fergus Nicol, John Arthur

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally 'brown', and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path - from 'brown' to 'white'.

Original language	English
Pages (from-to)	76-78
Number of pages	3
Journal	FEBS Letters
Volume	322
Issue number	1
Publication status	Published - 3 May 1993

Keywords

BROWN ADIPOSE TISSUE
WHITE ADIPOSE TISSUE
UNCOUPLING PROTEIN
IODOTHYRONINE 5'-DEIODINASE
WESTERN BLOTTING
NORTHERN BLOTTING
STIMULATION
EXPRESSION
BOVINE
RNA

Cite this

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title = "PRESENCE OF THE BROWN FAT-SPECIFIC MITOCHONDRIAL UNCOUPLING PROTEIN AND IODOTHYRONINE 5'-DEIODINASE ACTIVITY IN SUBCUTANEOUS ADIPOSE-TISSUE OF NEONATAL LAMBS",

abstract = "Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally 'brown', and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path - from 'brown' to 'white'.",

keywords = "BROWN ADIPOSE TISSUE, WHITE ADIPOSE TISSUE, UNCOUPLING PROTEIN, IODOTHYRONINE 5'-DEIODINASE, WESTERN BLOTTING, NORTHERN BLOTTING, STIMULATION, EXPRESSION, BOVINE, RNA",

author = "P TRAYHURN and THOMAS, {M E A} and Jackie Duncan and Fergus Nicol and John Arthur",

year = "1993",

month = may,

day = "3",

language = "English",

volume = "322",

pages = "76--78",

journal = "FEBS Letters",

issn = "0014-5793",

publisher = "Wiley",

number = "1",

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T1 - PRESENCE OF THE BROWN FAT-SPECIFIC MITOCHONDRIAL UNCOUPLING PROTEIN AND IODOTHYRONINE 5'-DEIODINASE ACTIVITY IN SUBCUTANEOUS ADIPOSE-TISSUE OF NEONATAL LAMBS

AU - TRAYHURN, P

AU - THOMAS, M E A

AU - Duncan, Jackie

AU - Nicol, Fergus

AU - Arthur, John

PY - 1993/5/3

Y1 - 1993/5/3

N2 - Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally 'brown', and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path - from 'brown' to 'white'.

AB - Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally 'brown', and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path - from 'brown' to 'white'.

KW - BROWN ADIPOSE TISSUE

KW - WHITE ADIPOSE TISSUE

KW - UNCOUPLING PROTEIN

KW - IODOTHYRONINE 5'-DEIODINASE

KW - WESTERN BLOTTING

KW - NORTHERN BLOTTING

KW - STIMULATION

KW - EXPRESSION

KW - BOVINE

KW - RNA

M3 - Article

SN - 0014-5793

VL - 322

SP - 76

EP - 78

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

PRESENCE OF THE BROWN FAT-SPECIFIC MITOCHONDRIAL UNCOUPLING PROTEIN AND IODOTHYRONINE 5'-DEIODINASE ACTIVITY IN SUBCUTANEOUS ADIPOSE-TISSUE OF NEONATAL LAMBS

Abstract

Keywords

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