PRESENCE OF THE BROWN FAT-SPECIFIC MITOCHONDRIAL UNCOUPLING PROTEIN AND IODOTHYRONINE 5'-DEIODINASE ACTIVITY IN SUBCUTANEOUS ADIPOSE-TISSUE OF NEONATAL LAMBS

P TRAYHURN, M E A THOMAS, Jackie Duncan, Fergus Nicol, John Arthur

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Abstract

Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous adipose tissue, as well as in the major internal fat depot (perirenal), of newborn lambs. These brown fat markers were not present, however, in adipose tissue of adult sheep. It is concluded that subcutaneous fat in newborn lambs is functionally 'brown', and similar to the internal fat; subcutaneous and internal adipose tissues follow a similar developmental path - from 'brown' to 'white'.

Original languageEnglish
Pages (from-to)76-78
Number of pages3
JournalFEBS Letters
Volume322
Issue number1
Publication statusPublished - 3 May 1993

Keywords

  • BROWN ADIPOSE TISSUE
  • WHITE ADIPOSE TISSUE
  • UNCOUPLING PROTEIN
  • IODOTHYRONINE 5'-DEIODINASE
  • WESTERN BLOTTING
  • NORTHERN BLOTTING
  • STIMULATION
  • EXPRESSION
  • BOVINE
  • RNA

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