Prognostic factors and survival of patients aged less than 45 years with colorectal cancer

S. D. Heys*, A. Sherif, J. S. Bagley, J. Brittenden, C. Smart, O. Eremin

*Corresponding author for this work

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Colorectal cancers in 92 patients aged 45 years and under presenting over a 20‐year period (1970–1990) were studied. A delay of more than 4 months in presentation was seen in 27 per cent of patients. All underwent surgery, 14 per cent emergency and 86 per cent elective, and follow‐up was available for 91 patients. Overall, 14 per cent of patients had Dukes A tumours, 32 per cent Dukes B, 36 per cent Dukes C and 18 per cent Dukes ‘D’. Local recurrence occurred in eight (9 per cent) of the 92 patients and overall 5‐ and 10‐year survival rates were 61 and 59 per cent. Multivariate analysis identified independent risk factors for local recurrence to be mucinous carcinoma (relative effect 4·9) and the presence of intramural vascular invasion by tumour (relative effect 9·4). For overall survival, independent risk factors were involvement of the regional lymph nodes by tumour (relative effect 2·0), extramural invasion by tumour cells (relative effect 3·0), tumour size (relative effect 1·8) and the presence of metastatic disease at initial diagnosis (relative effect 3·7).

Original languageEnglish
Pages (from-to)685-688
Number of pages4
JournalBritish Journal of Surgery
Volume81
Issue number5
DOIs
Publication statusPublished - May 1994

Fingerprint

Colorectal Neoplasms
Survival
Neoplasms
Recurrence
Mucinous Adenocarcinoma
Blood Vessels
Emergencies
Multivariate Analysis
Survival Rate
Lymph Nodes

ASJC Scopus subject areas

  • Surgery

Cite this

Prognostic factors and survival of patients aged less than 45 years with colorectal cancer. / Heys, S. D.; Sherif, A.; Bagley, J. S.; Brittenden, J.; Smart, C.; Eremin, O.

In: British Journal of Surgery, Vol. 81, No. 5, 05.1994, p. 685-688.

Research output: Contribution to journalArticle

Heys, S. D. ; Sherif, A. ; Bagley, J. S. ; Brittenden, J. ; Smart, C. ; Eremin, O. / Prognostic factors and survival of patients aged less than 45 years with colorectal cancer. In: British Journal of Surgery. 1994 ; Vol. 81, No. 5. pp. 685-688.
@article{4cf09962b5614355a10db35900fb3398,
title = "Prognostic factors and survival of patients aged less than 45 years with colorectal cancer",
abstract = "Colorectal cancers in 92 patients aged 45 years and under presenting over a 20‐year period (1970–1990) were studied. A delay of more than 4 months in presentation was seen in 27 per cent of patients. All underwent surgery, 14 per cent emergency and 86 per cent elective, and follow‐up was available for 91 patients. Overall, 14 per cent of patients had Dukes A tumours, 32 per cent Dukes B, 36 per cent Dukes C and 18 per cent Dukes ‘D’. Local recurrence occurred in eight (9 per cent) of the 92 patients and overall 5‐ and 10‐year survival rates were 61 and 59 per cent. Multivariate analysis identified independent risk factors for local recurrence to be mucinous carcinoma (relative effect 4·9) and the presence of intramural vascular invasion by tumour (relative effect 9·4). For overall survival, independent risk factors were involvement of the regional lymph nodes by tumour (relative effect 2·0), extramural invasion by tumour cells (relative effect 3·0), tumour size (relative effect 1·8) and the presence of metastatic disease at initial diagnosis (relative effect 3·7).",
author = "Heys, {S. D.} and A. Sherif and Bagley, {J. S.} and J. Brittenden and C. Smart and O. Eremin",
year = "1994",
month = "5",
doi = "10.1002/bjs.1800810519",
language = "English",
volume = "81",
pages = "685--688",
journal = "British Journal of Surgery",
issn = "0007-1323",
publisher = "British Journal of Surgery",
number = "5",

}

TY - JOUR

T1 - Prognostic factors and survival of patients aged less than 45 years with colorectal cancer

AU - Heys, S. D.

AU - Sherif, A.

AU - Bagley, J. S.

AU - Brittenden, J.

AU - Smart, C.

AU - Eremin, O.

PY - 1994/5

Y1 - 1994/5

N2 - Colorectal cancers in 92 patients aged 45 years and under presenting over a 20‐year period (1970–1990) were studied. A delay of more than 4 months in presentation was seen in 27 per cent of patients. All underwent surgery, 14 per cent emergency and 86 per cent elective, and follow‐up was available for 91 patients. Overall, 14 per cent of patients had Dukes A tumours, 32 per cent Dukes B, 36 per cent Dukes C and 18 per cent Dukes ‘D’. Local recurrence occurred in eight (9 per cent) of the 92 patients and overall 5‐ and 10‐year survival rates were 61 and 59 per cent. Multivariate analysis identified independent risk factors for local recurrence to be mucinous carcinoma (relative effect 4·9) and the presence of intramural vascular invasion by tumour (relative effect 9·4). For overall survival, independent risk factors were involvement of the regional lymph nodes by tumour (relative effect 2·0), extramural invasion by tumour cells (relative effect 3·0), tumour size (relative effect 1·8) and the presence of metastatic disease at initial diagnosis (relative effect 3·7).

AB - Colorectal cancers in 92 patients aged 45 years and under presenting over a 20‐year period (1970–1990) were studied. A delay of more than 4 months in presentation was seen in 27 per cent of patients. All underwent surgery, 14 per cent emergency and 86 per cent elective, and follow‐up was available for 91 patients. Overall, 14 per cent of patients had Dukes A tumours, 32 per cent Dukes B, 36 per cent Dukes C and 18 per cent Dukes ‘D’. Local recurrence occurred in eight (9 per cent) of the 92 patients and overall 5‐ and 10‐year survival rates were 61 and 59 per cent. Multivariate analysis identified independent risk factors for local recurrence to be mucinous carcinoma (relative effect 4·9) and the presence of intramural vascular invasion by tumour (relative effect 9·4). For overall survival, independent risk factors were involvement of the regional lymph nodes by tumour (relative effect 2·0), extramural invasion by tumour cells (relative effect 3·0), tumour size (relative effect 1·8) and the presence of metastatic disease at initial diagnosis (relative effect 3·7).

UR - http://www.scopus.com/inward/record.url?scp=0028199129&partnerID=8YFLogxK

U2 - 10.1002/bjs.1800810519

DO - 10.1002/bjs.1800810519

M3 - Article

VL - 81

SP - 685

EP - 688

JO - British Journal of Surgery

JF - British Journal of Surgery

SN - 0007-1323

IS - 5

ER -